GNL2

 

Full name: G protein nucleolar 2 Alias Symbol: Ngp-1|HUMAUANTIG|Nog2|Nug2
Type: protein-coding gene Cytoband: 1p34.3
Entrez ID: 29889 HGNC ID: HGNC:29925 Ensembl Gene: ENSG00000134697 OMIM ID: 609365
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of GNL2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNL2 29889 201948_at 0.5479 0.2874
GSE20347 GNL2 29889 201948_at 0.2800 0.1058
GSE23400 GNL2 29889 201948_at 0.4777 0.0000
GSE26886 GNL2 29889 201948_at 1.0017 0.0002
GSE29001 GNL2 29889 201948_at 0.2801 0.3409
GSE38129 GNL2 29889 201948_at 0.4264 0.0019
GSE45670 GNL2 29889 201948_at 0.2397 0.1181
GSE53622 GNL2 29889 49438 0.4975 0.0000
GSE53624 GNL2 29889 49438 0.5450 0.0000
GSE63941 GNL2 29889 201948_at -0.0035 0.9948
GSE77861 GNL2 29889 201948_at 0.3376 0.3132
GSE97050 GNL2 29889 A_23_P34578 0.7492 0.1782
SRP007169 GNL2 29889 RNAseq 0.3957 0.3579
SRP008496 GNL2 29889 RNAseq 0.3046 0.2277
SRP064894 GNL2 29889 RNAseq 0.4423 0.0048
SRP133303 GNL2 29889 RNAseq 0.5287 0.0039
SRP159526 GNL2 29889 RNAseq 0.2315 0.4134
SRP193095 GNL2 29889 RNAseq 0.1980 0.0346
SRP219564 GNL2 29889 RNAseq 0.5781 0.2498
TCGA GNL2 29889 RNAseq 0.1869 0.0003

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by GNL2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNL2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNL2 29889 2 4 24
GSE20123 GNL2 29889 2 3 25
GSE43470 GNL2 29889 7 3 33
GSE46452 GNL2 29889 4 1 54
GSE47630 GNL2 29889 8 3 29
GSE54993 GNL2 29889 1 1 68
GSE54994 GNL2 29889 11 2 40
GSE60625 GNL2 29889 0 0 11
GSE74703 GNL2 29889 6 2 28
GSE74704 GNL2 29889 1 0 19
TCGA GNL2 29889 12 16 68

Total number of gains: 54; Total number of losses: 35; Total Number of normals: 399.  

 

Somatic mutations of GNL2:

 

Generating mutation plots.

 

Highly correlated genes for GNL2:

 

Showing top 20/1227 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNL2MTHFD1L0.763528303
GNL2ROMO10.760283303
GNL2TIGD10.758437303
GNL2GPR1530.734973404
GNL2UCK20.733825303
GNL2ALKBH60.732855303
GNL2FAM89A0.727951303
GNL2ZFYVE270.724879303
GNL2PET1170.723621303
GNL2RGS10.711736303
GNL2MMS190.697496303
GNL2UBE2W0.697428303
GNL2ZNF4320.695306303
GNL2SRSF20.693519303
GNL2RAD180.69237303
GNL2MED80.688405303
GNL2TMEM2370.688117403
GNL2ANKRD170.686163403
GNL2NOP140.684333707
GNL2COX170.682573303

For details and further investigation, click here