| Full name: GDNF family receptor alpha 2 | Alias Symbol: RETL2|GDNFRB|NTNRA|TRNR2 | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 2675 | HGNC ID: HGNC:4244 | Ensembl Gene: ENSG00000168546 | OMIM ID: 601956 |
| Drug and gene relationship at DGIdb | |||
Expression of GFRA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GFRA2 | 2675 | 205721_at | -0.2852 | 0.3490 | |
| GSE20347 | GFRA2 | 2675 | 205722_s_at | 0.0190 | 0.8428 | |
| GSE23400 | GFRA2 | 2675 | 205721_at | -0.2344 | 0.0000 | |
| GSE26886 | GFRA2 | 2675 | 205721_at | 0.1373 | 0.2711 | |
| GSE29001 | GFRA2 | 2675 | 205721_at | -0.0343 | 0.8644 | |
| GSE38129 | GFRA2 | 2675 | 205722_s_at | -0.2219 | 0.0119 | |
| GSE45670 | GFRA2 | 2675 | 205721_at | -0.2329 | 0.0299 | |
| GSE53622 | GFRA2 | 2675 | 70093 | -0.0474 | 0.6596 | |
| GSE53624 | GFRA2 | 2675 | 70093 | -0.1862 | 0.0093 | |
| GSE63941 | GFRA2 | 2675 | 205721_at | 0.0925 | 0.5241 | |
| GSE77861 | GFRA2 | 2675 | 205722_s_at | -0.1712 | 0.0446 | |
| GSE97050 | GFRA2 | 2675 | A_33_P3317580 | -0.0696 | 0.8328 | |
| SRP133303 | GFRA2 | 2675 | RNAseq | -1.0686 | 0.0736 | |
| SRP159526 | GFRA2 | 2675 | RNAseq | -0.7720 | 0.1814 | |
| SRP219564 | GFRA2 | 2675 | RNAseq | -0.4300 | 0.6896 | |
| TCGA | GFRA2 | 2675 | RNAseq | -1.5725 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GFRA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GFRA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GFRA2 | 2675 | 4 | 11 | 15 | |
| GSE20123 | GFRA2 | 2675 | 4 | 11 | 15 | |
| GSE43470 | GFRA2 | 2675 | 4 | 9 | 30 | |
| GSE46452 | GFRA2 | 2675 | 13 | 13 | 33 | |
| GSE47630 | GFRA2 | 2675 | 10 | 8 | 22 | |
| GSE54993 | GFRA2 | 2675 | 2 | 14 | 54 | |
| GSE54994 | GFRA2 | 2675 | 8 | 18 | 27 | |
| GSE60625 | GFRA2 | 2675 | 3 | 0 | 8 | |
| GSE74703 | GFRA2 | 2675 | 4 | 7 | 25 | |
| GSE74704 | GFRA2 | 2675 | 3 | 7 | 10 | |
| TCGA | GFRA2 | 2675 | 13 | 43 | 40 |
Total number of gains: 68; Total number of losses: 141; Total Number of normals: 279.
Somatic mutations of GFRA2:
Generating mutation plots.
Highly correlated genes for GFRA2:
Showing top 20/924 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GFRA2 | DRGX | 0.755505 | 3 | 0 | 3 |
| GFRA2 | PRSS38 | 0.738446 | 3 | 0 | 3 |
| GFRA2 | SYCE3 | 0.729522 | 3 | 0 | 3 |
| GFRA2 | CCDC157 | 0.724786 | 3 | 0 | 3 |
| GFRA2 | SERTM1 | 0.723255 | 3 | 0 | 3 |
| GFRA2 | INHBC | 0.72195 | 3 | 0 | 3 |
| GFRA2 | LCN8 | 0.715841 | 4 | 0 | 3 |
| GFRA2 | MAGEA8 | 0.715046 | 3 | 0 | 3 |
| GFRA2 | ADAM21 | 0.714523 | 4 | 0 | 4 |
| GFRA2 | LRRC3C | 0.714408 | 3 | 0 | 3 |
| GFRA2 | ACSM3 | 0.713288 | 3 | 0 | 3 |
| GFRA2 | OTOG | 0.713279 | 3 | 0 | 3 |
| GFRA2 | RIPK4 | 0.710224 | 3 | 0 | 3 |
| GFRA2 | C9orf106 | 0.708774 | 3 | 0 | 3 |
| GFRA2 | PRODH2 | 0.705193 | 6 | 0 | 6 |
| GFRA2 | SLC37A1 | 0.701902 | 3 | 0 | 3 |
| GFRA2 | DCDC1 | 0.699946 | 3 | 0 | 3 |
| GFRA2 | MRGPRD | 0.697677 | 3 | 0 | 3 |
| GFRA2 | MAG | 0.696284 | 5 | 0 | 4 |
| GFRA2 | PRAMEF12 | 0.695349 | 5 | 0 | 5 |
For details and further investigation, click here
