| Full name: programmed cell death 1 ligand 2 | Alias Symbol: PD-L2|Btdc|PDL2|bA574F11.2|CD273|B7-DC | ||
| Type: protein-coding gene | Cytoband: 9p24.1 | ||
| Entrez ID: 80380 | HGNC ID: HGNC:18731 | Ensembl Gene: ENSG00000197646 | OMIM ID: 605723 |
| Drug and gene relationship at DGIdb | |||
Expression of PDCD1LG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDCD1LG2 | 80380 | 224399_at | 0.0358 | 0.9304 | |
| GSE20347 | PDCD1LG2 | 80380 | 220049_s_at | -0.0700 | 0.3814 | |
| GSE23400 | PDCD1LG2 | 80380 | 220049_s_at | -0.0901 | 0.0110 | |
| GSE26886 | PDCD1LG2 | 80380 | 224399_at | -0.2464 | 0.0068 | |
| GSE29001 | PDCD1LG2 | 80380 | 220049_s_at | -0.0536 | 0.7714 | |
| GSE38129 | PDCD1LG2 | 80380 | 220049_s_at | -0.0814 | 0.2006 | |
| GSE45670 | PDCD1LG2 | 80380 | 224399_at | 0.0504 | 0.6731 | |
| GSE53622 | PDCD1LG2 | 80380 | 68346 | 0.7620 | 0.0000 | |
| GSE53624 | PDCD1LG2 | 80380 | 68346 | 1.1253 | 0.0000 | |
| GSE63941 | PDCD1LG2 | 80380 | 224399_at | -1.4399 | 0.0009 | |
| GSE77861 | PDCD1LG2 | 80380 | 224399_at | -0.0669 | 0.6164 | |
| GSE97050 | PDCD1LG2 | 80380 | A_33_P3213707 | 1.0496 | 0.1733 | |
| SRP007169 | PDCD1LG2 | 80380 | RNAseq | 2.1641 | 0.0001 | |
| SRP008496 | PDCD1LG2 | 80380 | RNAseq | 2.3531 | 0.0000 | |
| SRP064894 | PDCD1LG2 | 80380 | RNAseq | 1.4061 | 0.0000 | |
| SRP133303 | PDCD1LG2 | 80380 | RNAseq | 0.5867 | 0.0275 | |
| SRP159526 | PDCD1LG2 | 80380 | RNAseq | 0.9196 | 0.1188 | |
| SRP193095 | PDCD1LG2 | 80380 | RNAseq | 1.4518 | 0.0000 | |
| SRP219564 | PDCD1LG2 | 80380 | RNAseq | 1.6396 | 0.0170 | |
| TCGA | PDCD1LG2 | 80380 | RNAseq | 0.5259 | 0.0131 |
Upregulated datasets: 6; Downregulated datasets: 1.
Survival by PDCD1LG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDCD1LG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDCD1LG2 | 80380 | 1 | 17 | 12 | |
| GSE20123 | PDCD1LG2 | 80380 | 1 | 17 | 12 | |
| GSE43470 | PDCD1LG2 | 80380 | 5 | 11 | 27 | |
| GSE46452 | PDCD1LG2 | 80380 | 2 | 23 | 34 | |
| GSE47630 | PDCD1LG2 | 80380 | 5 | 26 | 9 | |
| GSE54993 | PDCD1LG2 | 80380 | 6 | 3 | 61 | |
| GSE54994 | PDCD1LG2 | 80380 | 9 | 17 | 27 | |
| GSE60625 | PDCD1LG2 | 80380 | 0 | 2 | 9 | |
| GSE74703 | PDCD1LG2 | 80380 | 5 | 8 | 23 | |
| GSE74704 | PDCD1LG2 | 80380 | 0 | 13 | 7 | |
| TCGA | PDCD1LG2 | 80380 | 14 | 50 | 32 |
Total number of gains: 48; Total number of losses: 187; Total Number of normals: 253.
Somatic mutations of PDCD1LG2:
Generating mutation plots.
Highly correlated genes for PDCD1LG2:
Showing top 20/363 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDCD1LG2 | TFEC | 0.764792 | 4 | 0 | 4 |
| PDCD1LG2 | VCAM1 | 0.755553 | 3 | 0 | 3 |
| PDCD1LG2 | IGSF6 | 0.741757 | 3 | 0 | 3 |
| PDCD1LG2 | C1QA | 0.73895 | 3 | 0 | 3 |
| PDCD1LG2 | EPSTI1 | 0.735201 | 4 | 0 | 3 |
| PDCD1LG2 | GGT5 | 0.729729 | 5 | 0 | 5 |
| PDCD1LG2 | C1QC | 0.726395 | 3 | 0 | 3 |
| PDCD1LG2 | TRPV2 | 0.723804 | 5 | 0 | 4 |
| PDCD1LG2 | GPC6 | 0.718098 | 4 | 0 | 4 |
| PDCD1LG2 | FCGR3A | 0.709471 | 3 | 0 | 3 |
| PDCD1LG2 | DPP4 | 0.704479 | 4 | 0 | 4 |
| PDCD1LG2 | ZNF583 | 0.698477 | 4 | 0 | 3 |
| PDCD1LG2 | TMEM173 | 0.696041 | 4 | 0 | 4 |
| PDCD1LG2 | TMEM200A | 0.694307 | 4 | 0 | 3 |
| PDCD1LG2 | NNMT | 0.693355 | 3 | 0 | 3 |
| PDCD1LG2 | LETM2 | 0.68243 | 3 | 0 | 3 |
| PDCD1LG2 | PRRX1 | 0.677933 | 6 | 0 | 6 |
| PDCD1LG2 | HAS2 | 0.675824 | 5 | 0 | 4 |
| PDCD1LG2 | SRM | 0.675471 | 3 | 0 | 3 |
| PDCD1LG2 | PDE4B | 0.675055 | 4 | 0 | 4 |
For details and further investigation, click here
