| Full name: translocator protein | Alias Symbol: PBR|MBR|PKBS|mDRC|DBI|IBP|pk18 | ||
| Type: protein-coding gene | Cytoband: 22q13.2 | ||
| Entrez ID: 706 | HGNC ID: HGNC:1158 | Ensembl Gene: ENSG00000100300 | OMIM ID: 109610 |
| Drug and gene relationship at DGIdb | |||
Expression of TSPO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TSPO | 706 | 202096_s_at | -0.4676 | 0.2669 | |
| GSE20347 | TSPO | 706 | 202096_s_at | -1.4893 | 0.0000 | |
| GSE23400 | TSPO | 706 | 202096_s_at | -0.8944 | 0.0000 | |
| GSE26886 | TSPO | 706 | 202096_s_at | -0.6738 | 0.0112 | |
| GSE29001 | TSPO | 706 | 202096_s_at | -1.3789 | 0.0011 | |
| GSE38129 | TSPO | 706 | 202096_s_at | -0.8986 | 0.0002 | |
| GSE45670 | TSPO | 706 | 202096_s_at | -0.6257 | 0.0017 | |
| GSE53622 | TSPO | 706 | 89380 | -0.7650 | 0.0000 | |
| GSE53624 | TSPO | 706 | 89380 | -1.0743 | 0.0000 | |
| GSE63941 | TSPO | 706 | 202096_s_at | -0.7039 | 0.5204 | |
| GSE77861 | TSPO | 706 | 202096_s_at | -0.8457 | 0.0053 | |
| GSE97050 | TSPO | 706 | A_33_P3251148 | -0.2641 | 0.5123 | |
| SRP007169 | TSPO | 706 | RNAseq | -2.7924 | 0.0000 | |
| SRP008496 | TSPO | 706 | RNAseq | -2.5697 | 0.0000 | |
| SRP064894 | TSPO | 706 | RNAseq | -0.6468 | 0.0795 | |
| SRP133303 | TSPO | 706 | RNAseq | -1.6034 | 0.0000 | |
| SRP159526 | TSPO | 706 | RNAseq | -1.6985 | 0.0000 | |
| SRP193095 | TSPO | 706 | RNAseq | -1.5583 | 0.0000 | |
| SRP219564 | TSPO | 706 | RNAseq | -0.7559 | 0.1851 | |
| TCGA | TSPO | 706 | RNAseq | 0.0424 | 0.4926 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by TSPO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TSPO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TSPO | 706 | 6 | 6 | 18 | |
| GSE20123 | TSPO | 706 | 6 | 5 | 19 | |
| GSE43470 | TSPO | 706 | 3 | 6 | 34 | |
| GSE46452 | TSPO | 706 | 31 | 2 | 26 | |
| GSE47630 | TSPO | 706 | 9 | 4 | 27 | |
| GSE54993 | TSPO | 706 | 3 | 6 | 61 | |
| GSE54994 | TSPO | 706 | 11 | 8 | 34 | |
| GSE60625 | TSPO | 706 | 5 | 0 | 6 | |
| GSE74703 | TSPO | 706 | 3 | 4 | 29 | |
| GSE74704 | TSPO | 706 | 3 | 3 | 14 | |
| TCGA | TSPO | 706 | 26 | 15 | 55 |
Total number of gains: 106; Total number of losses: 59; Total Number of normals: 323.
Somatic mutations of TSPO:
Generating mutation plots.
Highly correlated genes for TSPO:
Showing top 20/1721 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TSPO | GRN | 0.79692 | 9 | 0 | 9 |
| TSPO | TOM1 | 0.790082 | 11 | 0 | 11 |
| TSPO | NAGK | 0.782496 | 11 | 0 | 11 |
| TSPO | SMAGP | 0.77424 | 10 | 0 | 10 |
| TSPO | TMED3 | 0.772017 | 10 | 0 | 10 |
| TSPO | SLC16A6 | 0.768682 | 11 | 0 | 11 |
| TSPO | ZFAND2B | 0.767383 | 7 | 0 | 7 |
| TSPO | RAB25 | 0.766635 | 12 | 0 | 11 |
| TSPO | UHRF2 | 0.765736 | 3 | 0 | 3 |
| TSPO | ULK3 | 0.764237 | 7 | 0 | 7 |
| TSPO | SCNN1B | 0.763625 | 10 | 0 | 10 |
| TSPO | FAM3D | 0.761517 | 6 | 0 | 6 |
| TSPO | EHD3 | 0.76044 | 11 | 0 | 10 |
| TSPO | TCP11L2 | 0.759276 | 4 | 0 | 4 |
| TSPO | SH3GL1 | 0.758068 | 11 | 0 | 10 |
| TSPO | ARHGAP27 | 0.756771 | 7 | 0 | 7 |
| TSPO | CA13 | 0.754084 | 3 | 0 | 3 |
| TSPO | EVPL | 0.753245 | 10 | 0 | 9 |
| TSPO | TP53I3 | 0.748122 | 11 | 0 | 11 |
| TSPO | C1GALT1C1 | 0.742812 | 3 | 0 | 3 |
For details and further investigation, click here
