| Full name: GM2 ganglioside activator | Alias Symbol: SAP-3 | ||
| Type: protein-coding gene | Cytoband: 5q33.1 | ||
| Entrez ID: 2760 | HGNC ID: HGNC:4367 | Ensembl Gene: ENSG00000196743 | OMIM ID: 613109 |
| Drug and gene relationship at DGIdb | |||
Expression of GM2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GM2A | 2760 | 212737_at | 0.4320 | 0.5683 | |
| GSE20347 | GM2A | 2760 | 212737_at | -0.5308 | 0.0013 | |
| GSE23400 | GM2A | 2760 | 212737_at | -0.1416 | 0.2309 | |
| GSE26886 | GM2A | 2760 | 212737_at | -0.6749 | 0.0459 | |
| GSE29001 | GM2A | 2760 | 212737_at | -0.5263 | 0.1092 | |
| GSE38129 | GM2A | 2760 | 212737_at | -0.1766 | 0.4513 | |
| GSE45670 | GM2A | 2760 | 212737_at | 0.7508 | 0.0004 | |
| GSE53622 | GM2A | 2760 | 59750 | -0.2047 | 0.0429 | |
| GSE53624 | GM2A | 2760 | 36894 | -0.2270 | 0.0064 | |
| GSE63941 | GM2A | 2760 | 212737_at | 0.2865 | 0.7776 | |
| GSE77861 | GM2A | 2760 | 212737_at | 0.0141 | 0.9773 | |
| GSE97050 | GM2A | 2760 | A_24_P925314 | -0.0965 | 0.6362 | |
| SRP007169 | GM2A | 2760 | RNAseq | -0.4309 | 0.4556 | |
| SRP008496 | GM2A | 2760 | RNAseq | -0.8751 | 0.0127 | |
| SRP064894 | GM2A | 2760 | RNAseq | 0.0612 | 0.7572 | |
| SRP133303 | GM2A | 2760 | RNAseq | -0.1033 | 0.5418 | |
| SRP159526 | GM2A | 2760 | RNAseq | -0.1007 | 0.8721 | |
| SRP193095 | GM2A | 2760 | RNAseq | -0.3037 | 0.1933 | |
| SRP219564 | GM2A | 2760 | RNAseq | 0.6880 | 0.2740 | |
| TCGA | GM2A | 2760 | RNAseq | 0.2593 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GM2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GM2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GM2A | 2760 | 1 | 12 | 17 | |
| GSE20123 | GM2A | 2760 | 1 | 12 | 17 | |
| GSE43470 | GM2A | 2760 | 1 | 11 | 31 | |
| GSE46452 | GM2A | 2760 | 0 | 27 | 32 | |
| GSE47630 | GM2A | 2760 | 0 | 20 | 20 | |
| GSE54993 | GM2A | 2760 | 9 | 1 | 60 | |
| GSE54994 | GM2A | 2760 | 2 | 15 | 36 | |
| GSE60625 | GM2A | 2760 | 0 | 0 | 11 | |
| GSE74703 | GM2A | 2760 | 1 | 8 | 27 | |
| GSE74704 | GM2A | 2760 | 1 | 7 | 12 | |
| TCGA | GM2A | 2760 | 5 | 37 | 54 |
Total number of gains: 21; Total number of losses: 150; Total Number of normals: 317.
Somatic mutations of GM2A:
Generating mutation plots.
Highly correlated genes for GM2A:
Showing top 20/211 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GM2A | GALR3 | 0.693174 | 3 | 0 | 3 |
| GM2A | PROC | 0.69124 | 4 | 0 | 4 |
| GM2A | ABCD3 | 0.688077 | 3 | 0 | 3 |
| GM2A | NKPD1 | 0.679196 | 3 | 0 | 3 |
| GM2A | MYH14 | 0.675034 | 4 | 0 | 3 |
| GM2A | HOMER1 | 0.672684 | 4 | 0 | 3 |
| GM2A | ERMP1 | 0.665811 | 4 | 0 | 4 |
| GM2A | ZNF219 | 0.651188 | 3 | 0 | 3 |
| GM2A | ZNF385A | 0.650466 | 4 | 0 | 3 |
| GM2A | SFXN5 | 0.645187 | 3 | 0 | 3 |
| GM2A | PAFAH2 | 0.631958 | 5 | 0 | 4 |
| GM2A | TTPAL | 0.628315 | 4 | 0 | 3 |
| GM2A | TSPAN10 | 0.626432 | 5 | 0 | 4 |
| GM2A | RIN1 | 0.625 | 9 | 0 | 7 |
| GM2A | LRCH4 | 0.624167 | 5 | 0 | 3 |
| GM2A | BBOX1 | 0.618071 | 6 | 0 | 6 |
| GM2A | CYP39A1 | 0.615094 | 4 | 0 | 3 |
| GM2A | PLA2G4F | 0.612196 | 7 | 0 | 5 |
| GM2A | SHROOM1 | 0.610268 | 4 | 0 | 3 |
| GM2A | SLC37A2 | 0.607396 | 4 | 0 | 3 |
For details and further investigation, click here
