| Full name: shroom family member 1 | Alias Symbol: APXL2|KIAA1960 | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 134549 | HGNC ID: HGNC:24084 | Ensembl Gene: ENSG00000164403 | OMIM ID: 611179 |
| Drug and gene relationship at DGIdb | |||
SHROOM1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of SHROOM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHROOM1 | 134549 | 239435_x_at | 0.0502 | 0.9251 | |
| GSE26886 | SHROOM1 | 134549 | 239435_x_at | 1.0442 | 0.0006 | |
| GSE45670 | SHROOM1 | 134549 | 239435_x_at | 0.0765 | 0.7807 | |
| GSE53622 | SHROOM1 | 134549 | 52897 | -0.1901 | 0.0706 | |
| GSE53624 | SHROOM1 | 134549 | 52897 | -0.0280 | 0.7798 | |
| GSE63941 | SHROOM1 | 134549 | 239435_x_at | -0.9081 | 0.0526 | |
| GSE77861 | SHROOM1 | 134549 | 239435_x_at | -0.0219 | 0.9145 | |
| GSE97050 | SHROOM1 | 134549 | A_33_P3245977 | -0.2195 | 0.2905 | |
| SRP007169 | SHROOM1 | 134549 | RNAseq | -1.0774 | 0.0565 | |
| SRP064894 | SHROOM1 | 134549 | RNAseq | 0.7361 | 0.0026 | |
| SRP133303 | SHROOM1 | 134549 | RNAseq | 0.2319 | 0.3603 | |
| SRP159526 | SHROOM1 | 134549 | RNAseq | 0.1888 | 0.5935 | |
| SRP193095 | SHROOM1 | 134549 | RNAseq | 0.0900 | 0.7348 | |
| SRP219564 | SHROOM1 | 134549 | RNAseq | 0.9068 | 0.0606 | |
| TCGA | SHROOM1 | 134549 | RNAseq | -0.3131 | 0.0006 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SHROOM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHROOM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHROOM1 | 134549 | 1 | 11 | 18 | |
| GSE20123 | SHROOM1 | 134549 | 2 | 11 | 17 | |
| GSE43470 | SHROOM1 | 134549 | 2 | 9 | 32 | |
| GSE46452 | SHROOM1 | 134549 | 0 | 27 | 32 | |
| GSE47630 | SHROOM1 | 134549 | 0 | 21 | 19 | |
| GSE54993 | SHROOM1 | 134549 | 9 | 1 | 60 | |
| GSE54994 | SHROOM1 | 134549 | 2 | 14 | 37 | |
| GSE60625 | SHROOM1 | 134549 | 0 | 0 | 11 | |
| GSE74703 | SHROOM1 | 134549 | 2 | 6 | 28 | |
| GSE74704 | SHROOM1 | 134549 | 1 | 5 | 14 | |
| TCGA | SHROOM1 | 134549 | 3 | 39 | 54 |
Total number of gains: 22; Total number of losses: 144; Total Number of normals: 322.
Somatic mutations of SHROOM1:
Generating mutation plots.
Highly correlated genes for SHROOM1:
Showing top 20/79 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHROOM1 | NACAD | 0.746817 | 3 | 0 | 3 |
| SHROOM1 | GSTM5 | 0.742981 | 3 | 0 | 3 |
| SHROOM1 | BMP10 | 0.724795 | 3 | 0 | 3 |
| SHROOM1 | NID2 | 0.713882 | 3 | 0 | 3 |
| SHROOM1 | TFAP2E | 0.713364 | 3 | 0 | 3 |
| SHROOM1 | OLIG3 | 0.712818 | 3 | 0 | 3 |
| SHROOM1 | KCNAB3 | 0.700502 | 4 | 0 | 4 |
| SHROOM1 | NAV3 | 0.696227 | 3 | 0 | 3 |
| SHROOM1 | SNAI2 | 0.692487 | 3 | 0 | 3 |
| SHROOM1 | RAD52 | 0.68923 | 4 | 0 | 3 |
| SHROOM1 | CDC42EP2 | 0.688515 | 3 | 0 | 3 |
| SHROOM1 | PINX1 | 0.683005 | 3 | 0 | 3 |
| SHROOM1 | OBSL1 | 0.680177 | 3 | 0 | 3 |
| SHROOM1 | RIN1 | 0.679132 | 4 | 0 | 4 |
| SHROOM1 | EYS | 0.678936 | 3 | 0 | 3 |
| SHROOM1 | SRCAP | 0.676852 | 3 | 0 | 3 |
| SHROOM1 | SNAI1 | 0.674276 | 3 | 0 | 3 |
| SHROOM1 | NEUROG1 | 0.673608 | 4 | 0 | 4 |
| SHROOM1 | IGHMBP2 | 0.672465 | 3 | 0 | 3 |
| SHROOM1 | FBLN7 | 0.666863 | 4 | 0 | 3 |
For details and further investigation, click here
