| Full name: homer scaffold protein 1 | Alias Symbol: Ves-1|SYN47|HOMER-1B | ||
| Type: protein-coding gene | Cytoband: 5q14.1 | ||
| Entrez ID: 9456 | HGNC ID: HGNC:17512 | Ensembl Gene: ENSG00000152413 | OMIM ID: 604798 |
| Drug and gene relationship at DGIdb | |||
HOMER1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway | |
| hsa04724 | Glutamatergic synapse |
Expression of HOMER1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HOMER1 | 9456 | 213793_s_at | 1.2128 | 0.1665 | |
| GSE20347 | HOMER1 | 9456 | 213793_s_at | 0.3195 | 0.2307 | |
| GSE23400 | HOMER1 | 9456 | 213793_s_at | 0.4822 | 0.0000 | |
| GSE26886 | HOMER1 | 9456 | 213793_s_at | 1.2358 | 0.0005 | |
| GSE29001 | HOMER1 | 9456 | 213793_s_at | 0.7870 | 0.0372 | |
| GSE38129 | HOMER1 | 9456 | 213793_s_at | 0.5191 | 0.0268 | |
| GSE45670 | HOMER1 | 9456 | 213793_s_at | 0.9268 | 0.0001 | |
| GSE53622 | HOMER1 | 9456 | 33911 | 0.3958 | 0.0015 | |
| GSE53624 | HOMER1 | 9456 | 33911 | 0.3763 | 0.0000 | |
| GSE63941 | HOMER1 | 9456 | 213793_s_at | -0.2553 | 0.6602 | |
| GSE77861 | HOMER1 | 9456 | 213793_s_at | 0.8322 | 0.0082 | |
| GSE97050 | HOMER1 | 9456 | A_33_P3372251 | 0.0539 | 0.7916 | |
| SRP007169 | HOMER1 | 9456 | RNAseq | 0.7175 | 0.0806 | |
| SRP008496 | HOMER1 | 9456 | RNAseq | 0.9790 | 0.0002 | |
| SRP064894 | HOMER1 | 9456 | RNAseq | 0.5978 | 0.0335 | |
| SRP133303 | HOMER1 | 9456 | RNAseq | 1.1510 | 0.0000 | |
| SRP159526 | HOMER1 | 9456 | RNAseq | 0.2441 | 0.5150 | |
| SRP193095 | HOMER1 | 9456 | RNAseq | 0.0942 | 0.6553 | |
| SRP219564 | HOMER1 | 9456 | RNAseq | 0.0405 | 0.9190 | |
| TCGA | HOMER1 | 9456 | RNAseq | 0.2871 | 0.0018 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by HOMER1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HOMER1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HOMER1 | 9456 | 1 | 13 | 16 | |
| GSE20123 | HOMER1 | 9456 | 1 | 13 | 16 | |
| GSE43470 | HOMER1 | 9456 | 1 | 12 | 30 | |
| GSE46452 | HOMER1 | 9456 | 0 | 28 | 31 | |
| GSE47630 | HOMER1 | 9456 | 1 | 19 | 20 | |
| GSE54993 | HOMER1 | 9456 | 8 | 1 | 61 | |
| GSE54994 | HOMER1 | 9456 | 1 | 19 | 33 | |
| GSE60625 | HOMER1 | 9456 | 0 | 0 | 11 | |
| GSE74703 | HOMER1 | 9456 | 1 | 8 | 27 | |
| GSE74704 | HOMER1 | 9456 | 1 | 6 | 13 | |
| TCGA | HOMER1 | 9456 | 5 | 49 | 42 |
Total number of gains: 20; Total number of losses: 168; Total Number of normals: 300.
Somatic mutations of HOMER1:
Generating mutation plots.
Highly correlated genes for HOMER1:
Showing top 20/324 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HOMER1 | BEND3 | 0.787173 | 5 | 0 | 5 |
| HOMER1 | TFAP2E | 0.772181 | 3 | 0 | 3 |
| HOMER1 | EYS | 0.752508 | 3 | 0 | 3 |
| HOMER1 | EDA | 0.742327 | 3 | 0 | 3 |
| HOMER1 | METTL18 | 0.721369 | 3 | 0 | 3 |
| HOMER1 | COL27A1 | 0.705217 | 5 | 0 | 5 |
| HOMER1 | MFSD10 | 0.704347 | 4 | 0 | 3 |
| HOMER1 | IRX2 | 0.702744 | 4 | 0 | 4 |
| HOMER1 | CCDC142 | 0.700343 | 4 | 0 | 3 |
| HOMER1 | TRMT10C | 0.692763 | 3 | 0 | 3 |
| HOMER1 | CPAMD8 | 0.692024 | 3 | 0 | 3 |
| HOMER1 | HOXC9 | 0.690715 | 5 | 0 | 4 |
| HOMER1 | RTN4RL1 | 0.685989 | 4 | 0 | 3 |
| HOMER1 | AGO2 | 0.680947 | 5 | 0 | 4 |
| HOMER1 | SALL4 | 0.680643 | 5 | 0 | 4 |
| HOMER1 | MDC1 | 0.680093 | 4 | 0 | 3 |
| HOMER1 | HSD17B14 | 0.675579 | 3 | 0 | 3 |
| HOMER1 | MSANTD2 | 0.674725 | 3 | 0 | 3 |
| HOMER1 | TIGD5 | 0.673337 | 4 | 0 | 3 |
| HOMER1 | GM2A | 0.672684 | 4 | 0 | 3 |
For details and further investigation, click here
