| Full name: cytochrome c oxidase copper chaperone COX17 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q13.33 | ||
| Entrez ID: 10063 | HGNC ID: HGNC:2264 | Ensembl Gene: ENSG00000138495 | OMIM ID: 604813 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of COX17:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COX17 | 10063 | 1558346_at | 0.8636 | 0.0854 | |
| GSE26886 | COX17 | 10063 | 1558346_at | 0.6079 | 0.0189 | |
| GSE45670 | COX17 | 10063 | 1558346_at | 0.5782 | 0.0001 | |
| GSE53622 | COX17 | 10063 | 125694 | 0.4783 | 0.0000 | |
| GSE53624 | COX17 | 10063 | 125694 | 0.8579 | 0.0000 | |
| GSE63941 | COX17 | 10063 | 1558346_at | 0.4902 | 0.2932 | |
| GSE77861 | COX17 | 10063 | 1558346_at | 0.0143 | 0.9313 | |
| GSE97050 | COX17 | 10063 | A_23_P65157 | 0.6247 | 0.1406 | |
| SRP007169 | COX17 | 10063 | RNAseq | 0.3938 | 0.3044 | |
| SRP008496 | COX17 | 10063 | RNAseq | 0.5440 | 0.0915 | |
| SRP064894 | COX17 | 10063 | RNAseq | 0.9600 | 0.0024 | |
| SRP133303 | COX17 | 10063 | RNAseq | 1.2424 | 0.0000 | |
| SRP159526 | COX17 | 10063 | RNAseq | 0.7367 | 0.0052 | |
| SRP193095 | COX17 | 10063 | RNAseq | 0.3377 | 0.0211 | |
| SRP219564 | COX17 | 10063 | RNAseq | 0.1589 | 0.6922 | |
| TCGA | COX17 | 10063 | RNAseq | -0.0107 | 0.8813 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by COX17 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COX17:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COX17 | 10063 | 18 | 0 | 12 | |
| GSE20123 | COX17 | 10063 | 18 | 0 | 12 | |
| GSE43470 | COX17 | 10063 | 21 | 1 | 21 | |
| GSE46452 | COX17 | 10063 | 14 | 5 | 40 | |
| GSE47630 | COX17 | 10063 | 16 | 5 | 19 | |
| GSE54993 | COX17 | 10063 | 2 | 6 | 62 | |
| GSE54994 | COX17 | 10063 | 30 | 4 | 19 | |
| GSE60625 | COX17 | 10063 | 0 | 6 | 5 | |
| GSE74703 | COX17 | 10063 | 17 | 1 | 18 | |
| GSE74704 | COX17 | 10063 | 13 | 0 | 7 | |
| TCGA | COX17 | 10063 | 53 | 7 | 36 |
Total number of gains: 202; Total number of losses: 35; Total Number of normals: 251.
Somatic mutations of COX17:
Generating mutation plots.
Highly correlated genes for COX17:
Showing top 20/438 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COX17 | HNRNPM | 0.695986 | 3 | 0 | 3 |
| COX17 | GNL2 | 0.682573 | 3 | 0 | 3 |
| COX17 | PPP1R37 | 0.681617 | 3 | 0 | 3 |
| COX17 | RPN1 | 0.674755 | 6 | 0 | 6 |
| COX17 | AGMAT | 0.671858 | 4 | 0 | 4 |
| COX17 | RYK | 0.670537 | 3 | 0 | 3 |
| COX17 | LPAR2 | 0.670109 | 3 | 0 | 3 |
| COX17 | UBAP2L | 0.665857 | 3 | 0 | 3 |
| COX17 | PLXNA1 | 0.663663 | 6 | 0 | 6 |
| COX17 | SF3B4 | 0.658282 | 4 | 0 | 3 |
| COX17 | GSK3B | 0.656052 | 5 | 0 | 5 |
| COX17 | ZNF628 | 0.655873 | 4 | 0 | 3 |
| COX17 | SLC38A6 | 0.653082 | 3 | 0 | 3 |
| COX17 | PPRC1 | 0.652179 | 4 | 0 | 3 |
| COX17 | PDHA1 | 0.651198 | 3 | 0 | 3 |
| COX17 | ZNF26 | 0.648375 | 3 | 0 | 3 |
| COX17 | TMEM259 | 0.648111 | 3 | 0 | 3 |
| COX17 | SLC39A3 | 0.646027 | 3 | 0 | 3 |
| COX17 | PDIA5 | 0.643146 | 4 | 0 | 4 |
| COX17 | EIF3C | 0.640089 | 4 | 0 | 3 |
For details and further investigation, click here
