| Full name: serine and arginine rich splicing factor 2 | Alias Symbol: SC-35|SC35|PR264|SFRS2A | ||
| Type: protein-coding gene | Cytoband: 17q25.2 | ||
| Entrez ID: 6427 | HGNC ID: HGNC:10783 | Ensembl Gene: ENSG00000161547 | OMIM ID: 600813 |
Screen Evidence:
| |||
SRSF2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05168 | Herpes simplex infection |
Expression of SRSF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | SRSF2 | 6427 | 6848 | 0.2613 | 0.0000 | |
| GSE53624 | SRSF2 | 6427 | 6848 | 0.2717 | 0.0000 | |
| GSE97050 | SRSF2 | 6427 | A_23_P77776 | 0.2592 | 0.2882 | |
| SRP007169 | SRSF2 | 6427 | RNAseq | 0.0139 | 0.9602 | |
| SRP008496 | SRSF2 | 6427 | RNAseq | 0.0081 | 0.9516 | |
| SRP064894 | SRSF2 | 6427 | RNAseq | 0.1837 | 0.3097 | |
| SRP133303 | SRSF2 | 6427 | RNAseq | 0.5336 | 0.0173 | |
| SRP159526 | SRSF2 | 6427 | RNAseq | 0.1773 | 0.4341 | |
| SRP193095 | SRSF2 | 6427 | RNAseq | 0.0876 | 0.3580 | |
| SRP219564 | SRSF2 | 6427 | RNAseq | 0.1393 | 0.6128 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRSF2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SRSF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRSF2 | 6427 | 7 | 2 | 21 | |
| GSE20123 | SRSF2 | 6427 | 7 | 2 | 21 | |
| GSE43470 | SRSF2 | 6427 | 4 | 3 | 36 | |
| GSE46452 | SRSF2 | 6427 | 33 | 1 | 25 | |
| GSE47630 | SRSF2 | 6427 | 8 | 1 | 31 | |
| GSE54993 | SRSF2 | 6427 | 2 | 5 | 63 | |
| GSE54994 | SRSF2 | 6427 | 10 | 4 | 39 | |
| GSE60625 | SRSF2 | 6427 | 6 | 0 | 5 | |
| GSE74703 | SRSF2 | 6427 | 4 | 1 | 31 | |
| GSE74704 | SRSF2 | 6427 | 5 | 1 | 14 | |
| TCGA | SRSF2 | 6427 | 31 | 10 | 55 |
Total number of gains: 117; Total number of losses: 30; Total Number of normals: 341.
Somatic mutations of SRSF2:
Generating mutation plots.
Highly correlated genes for SRSF2:
Showing top 20/119 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRSF2 | SFPQ | 0.799943 | 3 | 0 | 3 |
| SRSF2 | PTBP1 | 0.743093 | 3 | 0 | 3 |
| SRSF2 | PAICS | 0.735222 | 3 | 0 | 3 |
| SRSF2 | ILF2 | 0.73456 | 3 | 0 | 3 |
| SRSF2 | TRA2B | 0.727429 | 3 | 0 | 3 |
| SRSF2 | NUF2 | 0.727185 | 3 | 0 | 3 |
| SRSF2 | DDX39A | 0.725787 | 3 | 0 | 3 |
| SRSF2 | TYMS | 0.723062 | 3 | 0 | 3 |
| SRSF2 | XPOT | 0.722822 | 3 | 0 | 3 |
| SRSF2 | ACTL6A | 0.722212 | 3 | 0 | 3 |
| SRSF2 | DTL | 0.718037 | 3 | 0 | 3 |
| SRSF2 | DNA2 | 0.717551 | 3 | 0 | 3 |
| SRSF2 | KNTC1 | 0.71559 | 3 | 0 | 3 |
| SRSF2 | TAF2 | 0.712351 | 3 | 0 | 3 |
| SRSF2 | ATR | 0.711772 | 3 | 0 | 3 |
| SRSF2 | CDCA3 | 0.70844 | 3 | 0 | 3 |
| SRSF2 | EFTUD2 | 0.707234 | 3 | 0 | 3 |
| SRSF2 | PPAT | 0.706726 | 3 | 0 | 3 |
| SRSF2 | MIS18A | 0.704944 | 3 | 0 | 3 |
| SRSF2 | BRIX1 | 0.704806 | 3 | 0 | 3 |
For details and further investigation, click here
