| Full name: glucose-6-phosphate isomerase | Alias Symbol: AMF|NLK | ||
| Type: protein-coding gene | Cytoband: 19q13.11 | ||
| Entrez ID: 2821 | HGNC ID: HGNC:4458 | Ensembl Gene: ENSG00000105220 | OMIM ID: 172400 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GPI:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPI | 2821 | 208308_s_at | 0.1490 | 0.7190 | |
| GSE20347 | GPI | 2821 | 208308_s_at | 0.3551 | 0.1803 | |
| GSE23400 | GPI | 2821 | 208308_s_at | 0.4439 | 0.0000 | |
| GSE26886 | GPI | 2821 | 208308_s_at | 0.0198 | 0.9288 | |
| GSE29001 | GPI | 2821 | 208308_s_at | 0.2760 | 0.4662 | |
| GSE38129 | GPI | 2821 | 208308_s_at | 0.4722 | 0.0070 | |
| GSE45670 | GPI | 2821 | 208308_s_at | 0.4299 | 0.1406 | |
| GSE53622 | GPI | 2821 | 108710 | 0.0761 | 0.4387 | |
| GSE53624 | GPI | 2821 | 108710 | 0.5787 | 0.0000 | |
| GSE63941 | GPI | 2821 | 208308_s_at | 1.4950 | 0.0048 | |
| GSE77861 | GPI | 2821 | 208308_s_at | 0.6147 | 0.1477 | |
| GSE97050 | GPI | 2821 | A_24_P108451 | -0.1610 | 0.5398 | |
| SRP007169 | GPI | 2821 | RNAseq | 1.0198 | 0.0221 | |
| SRP008496 | GPI | 2821 | RNAseq | 0.5613 | 0.0848 | |
| SRP064894 | GPI | 2821 | RNAseq | 0.7557 | 0.0002 | |
| SRP133303 | GPI | 2821 | RNAseq | 0.4849 | 0.0481 | |
| SRP159526 | GPI | 2821 | RNAseq | 0.9018 | 0.0163 | |
| SRP193095 | GPI | 2821 | RNAseq | 0.2344 | 0.0192 | |
| SRP219564 | GPI | 2821 | RNAseq | 0.1421 | 0.7412 | |
| TCGA | GPI | 2821 | RNAseq | 0.1948 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by GPI expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPI:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPI | 2821 | 6 | 5 | 19 | |
| GSE20123 | GPI | 2821 | 6 | 4 | 20 | |
| GSE43470 | GPI | 2821 | 5 | 7 | 31 | |
| GSE46452 | GPI | 2821 | 48 | 1 | 10 | |
| GSE47630 | GPI | 2821 | 9 | 5 | 26 | |
| GSE54993 | GPI | 2821 | 17 | 3 | 50 | |
| GSE54994 | GPI | 2821 | 9 | 9 | 35 | |
| GSE60625 | GPI | 2821 | 9 | 0 | 2 | |
| GSE74703 | GPI | 2821 | 5 | 4 | 27 | |
| GSE74704 | GPI | 2821 | 6 | 2 | 12 | |
| TCGA | GPI | 2821 | 18 | 12 | 66 |
Total number of gains: 138; Total number of losses: 52; Total Number of normals: 298.
Somatic mutations of GPI:
Generating mutation plots.
Highly correlated genes for GPI:
Showing top 20/422 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPI | TMEM173 | 0.70109 | 3 | 0 | 3 |
| GPI | ADNP | 0.697062 | 3 | 0 | 3 |
| GPI | IFITM2 | 0.675512 | 3 | 0 | 3 |
| GPI | KLF16 | 0.671679 | 3 | 0 | 3 |
| GPI | ILK | 0.667706 | 3 | 0 | 3 |
| GPI | ASXL2 | 0.666276 | 3 | 0 | 3 |
| GPI | YDJC | 0.656443 | 4 | 0 | 4 |
| GPI | C17orf53 | 0.655251 | 3 | 0 | 3 |
| GPI | DYRK2 | 0.654552 | 3 | 0 | 3 |
| GPI | ATXN2 | 0.652516 | 3 | 0 | 3 |
| GPI | HNRNPU | 0.651946 | 5 | 0 | 4 |
| GPI | ARHGEF2 | 0.648598 | 3 | 0 | 3 |
| GPI | MFGE8 | 0.643893 | 4 | 0 | 4 |
| GPI | ST6GALNAC2 | 0.643311 | 4 | 0 | 3 |
| GPI | EIF3G | 0.6397 | 5 | 0 | 3 |
| GPI | TP53I13 | 0.638679 | 5 | 0 | 4 |
| GPI | ZNF706 | 0.636291 | 3 | 0 | 3 |
| GPI | MSN | 0.63443 | 4 | 0 | 3 |
| GPI | ZNF683 | 0.63436 | 4 | 0 | 3 |
| GPI | IL6R | 0.632973 | 3 | 0 | 3 |
For details and further investigation, click here
