| Full name: chromosome 17 open reading frame 53 | Alias Symbol: MGC3130 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 78995 | HGNC ID: HGNC:28460 | Ensembl Gene: ENSG00000125319 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of C17orf53:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | C17orf53 | 78995 | 219879_s_at | 0.1933 | 0.4837 | |
| GSE20347 | C17orf53 | 78995 | 219879_s_at | 0.2997 | 0.0012 | |
| GSE23400 | C17orf53 | 78995 | 219879_s_at | 0.0034 | 0.9496 | |
| GSE26886 | C17orf53 | 78995 | 219879_s_at | 0.4414 | 0.0013 | |
| GSE29001 | C17orf53 | 78995 | 219879_s_at | 0.1017 | 0.4055 | |
| GSE38129 | C17orf53 | 78995 | 219879_s_at | 0.2560 | 0.0285 | |
| GSE45670 | C17orf53 | 78995 | 219879_s_at | -0.0180 | 0.9057 | |
| GSE53622 | C17orf53 | 78995 | 119985 | 1.3527 | 0.0000 | |
| GSE53624 | C17orf53 | 78995 | 119985 | 1.0874 | 0.0000 | |
| GSE63941 | C17orf53 | 78995 | 219879_s_at | 0.9455 | 0.0004 | |
| GSE77861 | C17orf53 | 78995 | 219879_s_at | 0.0675 | 0.6634 | |
| GSE97050 | C17orf53 | 78995 | A_33_P3295838 | 1.3929 | 0.1505 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by C17orf53 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of C17orf53:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | C17orf53 | 78995 | 5 | 2 | 23 | |
| GSE20123 | C17orf53 | 78995 | 5 | 2 | 23 | |
| GSE43470 | C17orf53 | 78995 | 1 | 2 | 40 | |
| GSE46452 | C17orf53 | 78995 | 32 | 0 | 27 | |
| GSE47630 | C17orf53 | 78995 | 9 | 0 | 31 | |
| GSE54993 | C17orf53 | 78995 | 3 | 4 | 63 | |
| GSE54994 | C17orf53 | 78995 | 8 | 5 | 40 | |
| GSE60625 | C17orf53 | 78995 | 4 | 0 | 7 | |
| GSE74703 | C17orf53 | 78995 | 1 | 1 | 34 | |
| GSE74704 | C17orf53 | 78995 | 3 | 1 | 16 | |
| TCGA | C17orf53 | 78995 | 23 | 7 | 66 |
Total number of gains: 94; Total number of losses: 24; Total Number of normals: 370.
Somatic mutations of C17orf53:
Generating mutation plots.
Highly correlated genes for C17orf53:
Showing top 20/964 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| C17orf53 | SLC19A1 | 0.744871 | 3 | 0 | 3 |
| C17orf53 | IQGAP3 | 0.732266 | 5 | 0 | 5 |
| C17orf53 | TOP2A | 0.719027 | 6 | 0 | 6 |
| C17orf53 | UBE2T | 0.71664 | 6 | 0 | 6 |
| C17orf53 | PSMB3 | 0.705604 | 6 | 0 | 5 |
| C17orf53 | MCM2 | 0.704594 | 8 | 0 | 7 |
| C17orf53 | KNSTRN | 0.703033 | 5 | 0 | 5 |
| C17orf53 | RFC4 | 0.702507 | 8 | 0 | 7 |
| C17orf53 | MCM4 | 0.698948 | 7 | 0 | 7 |
| C17orf53 | ESCO2 | 0.692416 | 5 | 0 | 5 |
| C17orf53 | PLK1 | 0.690564 | 8 | 0 | 7 |
| C17orf53 | MYBL2 | 0.688933 | 9 | 0 | 7 |
| C17orf53 | MRPL38 | 0.688574 | 4 | 0 | 3 |
| C17orf53 | ZNF367 | 0.683776 | 5 | 0 | 5 |
| C17orf53 | TRIP13 | 0.68319 | 8 | 0 | 8 |
| C17orf53 | SAMD1 | 0.682512 | 5 | 0 | 5 |
| C17orf53 | TK1 | 0.681608 | 9 | 0 | 7 |
| C17orf53 | TROAP | 0.68085 | 9 | 0 | 8 |
| C17orf53 | SOX15 | 0.680512 | 4 | 0 | 3 |
| C17orf53 | C19orf48 | 0.679683 | 4 | 0 | 4 |
For details and further investigation, click here
