| Full name: PR/SET domain 8 | Alias Symbol: KMT8D | ||
| Type: protein-coding gene | Cytoband: 4q21.21 | ||
| Entrez ID: 56978 | HGNC ID: HGNC:13993 | Ensembl Gene: ENSG00000152784 | OMIM ID: 616639 |
| Drug and gene relationship at DGIdb | |||
Expression of PRDM8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRDM8 | 56978 | 219835_at | 0.0107 | 0.9797 | |
| GSE20347 | PRDM8 | 56978 | 219835_at | -0.0159 | 0.8363 | |
| GSE23400 | PRDM8 | 56978 | 219835_at | -0.1400 | 0.0000 | |
| GSE26886 | PRDM8 | 56978 | 219835_at | 0.4650 | 0.0057 | |
| GSE29001 | PRDM8 | 56978 | 219835_at | -0.0672 | 0.5893 | |
| GSE38129 | PRDM8 | 56978 | 219835_at | -0.1180 | 0.0859 | |
| GSE45670 | PRDM8 | 56978 | 219835_at | -0.0304 | 0.7684 | |
| GSE53622 | PRDM8 | 56978 | 91041 | -1.5211 | 0.0000 | |
| GSE53624 | PRDM8 | 56978 | 91041 | -1.7986 | 0.0000 | |
| GSE63941 | PRDM8 | 56978 | 239111_at | 0.3510 | 0.0868 | |
| GSE77861 | PRDM8 | 56978 | 239111_at | -0.1970 | 0.1774 | |
| GSE97050 | PRDM8 | 56978 | A_23_P255328 | -0.9762 | 0.1316 | |
| SRP064894 | PRDM8 | 56978 | RNAseq | -0.2645 | 0.3827 | |
| SRP133303 | PRDM8 | 56978 | RNAseq | -0.1919 | 0.6123 | |
| SRP159526 | PRDM8 | 56978 | RNAseq | -0.5151 | 0.2583 | |
| SRP219564 | PRDM8 | 56978 | RNAseq | -0.5417 | 0.5338 | |
| TCGA | PRDM8 | 56978 | RNAseq | -0.6093 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PRDM8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRDM8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRDM8 | 56978 | 0 | 10 | 20 | |
| GSE20123 | PRDM8 | 56978 | 1 | 10 | 19 | |
| GSE43470 | PRDM8 | 56978 | 0 | 13 | 30 | |
| GSE46452 | PRDM8 | 56978 | 1 | 36 | 22 | |
| GSE47630 | PRDM8 | 56978 | 1 | 19 | 20 | |
| GSE54993 | PRDM8 | 56978 | 8 | 0 | 62 | |
| GSE54994 | PRDM8 | 56978 | 0 | 9 | 44 | |
| GSE60625 | PRDM8 | 56978 | 0 | 0 | 11 | |
| GSE74703 | PRDM8 | 56978 | 0 | 11 | 25 | |
| GSE74704 | PRDM8 | 56978 | 1 | 5 | 14 | |
| TCGA | PRDM8 | 56978 | 11 | 34 | 51 |
Total number of gains: 23; Total number of losses: 147; Total Number of normals: 318.
Somatic mutations of PRDM8:
Generating mutation plots.
Highly correlated genes for PRDM8:
Showing top 20/739 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRDM8 | CYP21A2 | 0.802785 | 3 | 0 | 3 |
| PRDM8 | MYOCD | 0.794601 | 3 | 0 | 3 |
| PRDM8 | XKR4 | 0.774847 | 3 | 0 | 3 |
| PRDM8 | CLEC3B | 0.754331 | 3 | 0 | 3 |
| PRDM8 | VMAC | 0.749733 | 3 | 0 | 3 |
| PRDM8 | DUSP1 | 0.743718 | 3 | 0 | 3 |
| PRDM8 | CACNB2 | 0.729668 | 4 | 0 | 4 |
| PRDM8 | NEGR1 | 0.729041 | 3 | 0 | 3 |
| PRDM8 | SGCA | 0.726021 | 5 | 0 | 5 |
| PRDM8 | RBPMS | 0.725137 | 4 | 0 | 4 |
| PRDM8 | YPEL5 | 0.724041 | 3 | 0 | 3 |
| PRDM8 | RGS7BP | 0.723611 | 3 | 0 | 3 |
| PRDM8 | TACR2 | 0.715814 | 4 | 0 | 4 |
| PRDM8 | ASB5 | 0.712671 | 3 | 0 | 3 |
| PRDM8 | CADM2 | 0.711897 | 4 | 0 | 4 |
| PRDM8 | NANOS3 | 0.709777 | 3 | 0 | 3 |
| PRDM8 | HIC2 | 0.70953 | 3 | 0 | 3 |
| PRDM8 | PCDH9 | 0.709239 | 4 | 0 | 3 |
| PRDM8 | LINC00311 | 0.707718 | 3 | 0 | 3 |
| PRDM8 | KLF6 | 0.70729 | 3 | 0 | 3 |
For details and further investigation, click here
