| Full name: G protein-coupled receptor 27 | Alias Symbol: SREB1 | ||
| Type: protein-coding gene | Cytoband: 3p13 | ||
| Entrez ID: 2850 | HGNC ID: HGNC:4482 | Ensembl Gene: ENSG00000170837 | OMIM ID: 605187 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR27:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR27 | 2850 | 227769_at | -0.3061 | 0.8360 | |
| GSE20347 | GPR27 | 2850 | 221306_at | -0.0099 | 0.9410 | |
| GSE23400 | GPR27 | 2850 | 221306_at | -0.1630 | 0.0001 | |
| GSE26886 | GPR27 | 2850 | 227769_at | -1.1003 | 0.0555 | |
| GSE29001 | GPR27 | 2850 | 221306_at | -0.0800 | 0.6318 | |
| GSE38129 | GPR27 | 2850 | 221306_at | -0.0804 | 0.3979 | |
| GSE45670 | GPR27 | 2850 | 227769_at | -0.7012 | 0.1725 | |
| GSE53622 | GPR27 | 2850 | 32019 | -1.6000 | 0.0000 | |
| GSE53624 | GPR27 | 2850 | 32019 | -1.7482 | 0.0000 | |
| GSE63941 | GPR27 | 2850 | 227769_at | 3.7433 | 0.0522 | |
| GSE77861 | GPR27 | 2850 | 227769_at | -0.5228 | 0.1506 | |
| GSE97050 | GPR27 | 2850 | A_23_P385835 | -0.5835 | 0.1532 | |
| SRP064894 | GPR27 | 2850 | RNAseq | -1.4032 | 0.0000 | |
| SRP133303 | GPR27 | 2850 | RNAseq | -0.4845 | 0.0853 | |
| SRP159526 | GPR27 | 2850 | RNAseq | 0.6995 | 0.0684 | |
| SRP219564 | GPR27 | 2850 | RNAseq | 0.2832 | 0.5398 | |
| TCGA | GPR27 | 2850 | RNAseq | 0.0261 | 0.9423 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by GPR27 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR27:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR27 | 2850 | 1 | 20 | 9 | |
| GSE20123 | GPR27 | 2850 | 1 | 20 | 9 | |
| GSE43470 | GPR27 | 2850 | 0 | 21 | 22 | |
| GSE46452 | GPR27 | 2850 | 2 | 17 | 40 | |
| GSE47630 | GPR27 | 2850 | 1 | 23 | 16 | |
| GSE54993 | GPR27 | 2850 | 5 | 3 | 62 | |
| GSE54994 | GPR27 | 2850 | 1 | 33 | 19 | |
| GSE60625 | GPR27 | 2850 | 3 | 1 | 7 | |
| GSE74703 | GPR27 | 2850 | 0 | 17 | 19 | |
| GSE74704 | GPR27 | 2850 | 1 | 13 | 6 | |
| TCGA | GPR27 | 2850 | 1 | 79 | 16 |
Total number of gains: 16; Total number of losses: 247; Total Number of normals: 225.
Somatic mutations of GPR27:
Generating mutation plots.
Highly correlated genes for GPR27:
Showing top 20/464 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR27 | OR10G8 | 0.825516 | 3 | 0 | 3 |
| GPR27 | OR2Z1 | 0.7274 | 3 | 0 | 3 |
| GPR27 | TUBB4A | 0.696415 | 3 | 0 | 3 |
| GPR27 | HES5 | 0.694523 | 3 | 0 | 3 |
| GPR27 | INHBC | 0.681869 | 3 | 0 | 3 |
| GPR27 | FAM163B | 0.679614 | 4 | 0 | 4 |
| GPR27 | GRIN1 | 0.678938 | 4 | 0 | 4 |
| GPR27 | HTR3B | 0.67319 | 4 | 0 | 4 |
| GPR27 | MUC22 | 0.669497 | 3 | 0 | 3 |
| GPR27 | KLHL10 | 0.667591 | 4 | 0 | 3 |
| GPR27 | LMAN1L | 0.664106 | 6 | 0 | 5 |
| GPR27 | TMPRSS5 | 0.663742 | 5 | 0 | 4 |
| GPR27 | NOXA1 | 0.663016 | 4 | 0 | 3 |
| GPR27 | MATN1 | 0.662024 | 3 | 0 | 3 |
| GPR27 | SPSB3 | 0.661827 | 5 | 0 | 5 |
| GPR27 | GUCY2F | 0.655708 | 3 | 0 | 3 |
| GPR27 | PRLH | 0.654631 | 4 | 0 | 4 |
| GPR27 | RRP1 | 0.654454 | 4 | 0 | 3 |
| GPR27 | KRT36 | 0.653744 | 4 | 0 | 4 |
| GPR27 | BTNL9 | 0.65112 | 4 | 0 | 3 |
For details and further investigation, click here
