| Full name: glutathione peroxidase 4 | Alias Symbol: PHGPx|MCSP | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 2879 | HGNC ID: HGNC:4556 | Ensembl Gene: ENSG00000167468 | OMIM ID: 138322 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GPX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPX4 | 2879 | 201106_at | 0.5674 | 0.2108 | |
| GSE20347 | GPX4 | 2879 | 201106_at | 0.5150 | 0.0070 | |
| GSE23400 | GPX4 | 2879 | 201106_at | 0.5403 | 0.0000 | |
| GSE26886 | GPX4 | 2879 | 201106_at | 1.2333 | 0.0000 | |
| GSE29001 | GPX4 | 2879 | 201106_at | 0.1953 | 0.7291 | |
| GSE38129 | GPX4 | 2879 | 201106_at | 0.4992 | 0.0009 | |
| GSE45670 | GPX4 | 2879 | 201106_at | -0.0900 | 0.6806 | |
| GSE53622 | GPX4 | 2879 | 90675 | 0.2969 | 0.0000 | |
| GSE53624 | GPX4 | 2879 | 90675 | 0.6609 | 0.0000 | |
| GSE63941 | GPX4 | 2879 | 201106_at | -0.0259 | 0.9726 | |
| GSE77861 | GPX4 | 2879 | 201106_at | 0.6506 | 0.0117 | |
| GSE97050 | GPX4 | 2879 | A_33_P3309662 | 0.3980 | 0.3261 | |
| SRP007169 | GPX4 | 2879 | RNAseq | 0.0529 | 0.8664 | |
| SRP008496 | GPX4 | 2879 | RNAseq | 0.1486 | 0.3761 | |
| SRP064894 | GPX4 | 2879 | RNAseq | 0.4191 | 0.1626 | |
| SRP133303 | GPX4 | 2879 | RNAseq | 0.6279 | 0.0028 | |
| SRP159526 | GPX4 | 2879 | RNAseq | 0.8535 | 0.0079 | |
| SRP193095 | GPX4 | 2879 | RNAseq | 0.1548 | 0.3269 | |
| SRP219564 | GPX4 | 2879 | RNAseq | 0.3496 | 0.2765 | |
| TCGA | GPX4 | 2879 | RNAseq | 0.1279 | 0.0101 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GPX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPX4 | 2879 | 4 | 6 | 20 | |
| GSE20123 | GPX4 | 2879 | 4 | 5 | 21 | |
| GSE43470 | GPX4 | 2879 | 1 | 9 | 33 | |
| GSE46452 | GPX4 | 2879 | 47 | 1 | 11 | |
| GSE47630 | GPX4 | 2879 | 5 | 7 | 28 | |
| GSE54993 | GPX4 | 2879 | 13 | 4 | 53 | |
| GSE54994 | GPX4 | 2879 | 8 | 15 | 30 | |
| GSE60625 | GPX4 | 2879 | 9 | 0 | 2 | |
| GSE74703 | GPX4 | 2879 | 1 | 7 | 28 | |
| GSE74704 | GPX4 | 2879 | 3 | 3 | 14 | |
| TCGA | GPX4 | 2879 | 8 | 25 | 63 |
Total number of gains: 103; Total number of losses: 82; Total Number of normals: 303.
Somatic mutations of GPX4:
Generating mutation plots.
Highly correlated genes for GPX4:
Showing top 20/933 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPX4 | COMMD7 | 0.753927 | 3 | 0 | 3 |
| GPX4 | ARL6IP4 | 0.724529 | 3 | 0 | 3 |
| GPX4 | SSBP4 | 0.718967 | 5 | 0 | 5 |
| GPX4 | CYP2S1 | 0.71848 | 3 | 0 | 3 |
| GPX4 | CENPV | 0.709236 | 4 | 0 | 4 |
| GPX4 | ZNF496 | 0.704356 | 4 | 0 | 3 |
| GPX4 | PRR15 | 0.702392 | 3 | 0 | 3 |
| GPX4 | GTF2IRD2 | 0.698621 | 4 | 0 | 4 |
| GPX4 | RAVER1 | 0.695213 | 4 | 0 | 3 |
| GPX4 | FMNL2 | 0.691761 | 3 | 0 | 3 |
| GPX4 | CCDC24 | 0.681097 | 4 | 0 | 4 |
| GPX4 | SMKR1 | 0.680197 | 3 | 0 | 3 |
| GPX4 | MAF1 | 0.677877 | 5 | 0 | 5 |
| GPX4 | CRTC2 | 0.673581 | 4 | 0 | 3 |
| GPX4 | PELI3 | 0.67227 | 3 | 0 | 3 |
| GPX4 | NR2C2AP | 0.665923 | 5 | 0 | 4 |
| GPX4 | HOXC9 | 0.664385 | 3 | 0 | 3 |
| GPX4 | NEURL1B | 0.663694 | 3 | 0 | 3 |
| GPX4 | NCOA5 | 0.661402 | 3 | 0 | 3 |
| GPX4 | GALNT18 | 0.661332 | 4 | 0 | 3 |
For details and further investigation, click here
