| Full name: glutamate ionotropic receptor kainate type subunit 1 | Alias Symbol: GluK1 | ||
| Type: protein-coding gene | Cytoband: 21q21.3 | ||
| Entrez ID: 2897 | HGNC ID: HGNC:4579 | Ensembl Gene: ENSG00000171189 | OMIM ID: 138245 |
| Drug and gene relationship at DGIdb | |||
GRIK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04724 | Glutamatergic synapse |
Expression of GRIK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRIK1 | 2897 | 214611_at | -0.0750 | 0.7951 | |
| GSE20347 | GRIK1 | 2897 | 214611_at | 0.0385 | 0.5996 | |
| GSE23400 | GRIK1 | 2897 | 214611_at | -0.0594 | 0.0281 | |
| GSE26886 | GRIK1 | 2897 | 214611_at | -0.3285 | 0.0623 | |
| GSE29001 | GRIK1 | 2897 | 214611_at | 0.0703 | 0.6681 | |
| GSE38129 | GRIK1 | 2897 | 214611_at | -0.0524 | 0.4851 | |
| GSE45670 | GRIK1 | 2897 | 214611_at | -0.0343 | 0.6444 | |
| GSE53622 | GRIK1 | 2897 | 28808 | -0.3850 | 0.0379 | |
| GSE53624 | GRIK1 | 2897 | 28808 | -0.8060 | 0.0000 | |
| GSE63941 | GRIK1 | 2897 | 214611_at | -0.2778 | 0.0425 | |
| GSE77861 | GRIK1 | 2897 | 214611_at | -0.0831 | 0.4903 | |
| SRP133303 | GRIK1 | 2897 | RNAseq | 0.3472 | 0.1371 | |
| SRP193095 | GRIK1 | 2897 | RNAseq | 0.5752 | 0.0063 | |
| TCGA | GRIK1 | 2897 | RNAseq | -2.4851 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GRIK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRIK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRIK1 | 2897 | 2 | 10 | 18 | |
| GSE20123 | GRIK1 | 2897 | 2 | 10 | 18 | |
| GSE43470 | GRIK1 | 2897 | 1 | 9 | 33 | |
| GSE46452 | GRIK1 | 2897 | 1 | 21 | 37 | |
| GSE47630 | GRIK1 | 2897 | 6 | 17 | 17 | |
| GSE54993 | GRIK1 | 2897 | 9 | 1 | 60 | |
| GSE54994 | GRIK1 | 2897 | 1 | 9 | 43 | |
| GSE60625 | GRIK1 | 2897 | 0 | 0 | 11 | |
| GSE74703 | GRIK1 | 2897 | 1 | 6 | 29 | |
| GSE74704 | GRIK1 | 2897 | 2 | 6 | 12 | |
| TCGA | GRIK1 | 2897 | 9 | 37 | 50 |
Total number of gains: 34; Total number of losses: 126; Total Number of normals: 328.
Somatic mutations of GRIK1:
Generating mutation plots.
Highly correlated genes for GRIK1:
Showing top 20/163 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRIK1 | MUC7 | 0.679859 | 3 | 0 | 3 |
| GRIK1 | SV2C | 0.655249 | 3 | 0 | 3 |
| GRIK1 | CHRNA4 | 0.631294 | 3 | 0 | 3 |
| GRIK1 | GPR37 | 0.630393 | 3 | 0 | 3 |
| GRIK1 | KCNA4 | 0.626852 | 5 | 0 | 4 |
| GRIK1 | TRPM3 | 0.622493 | 3 | 0 | 3 |
| GRIK1 | CDKL5 | 0.612197 | 3 | 0 | 3 |
| GRIK1 | MYF5 | 0.610038 | 3 | 0 | 3 |
| GRIK1 | GAD2 | 0.609872 | 5 | 0 | 4 |
| GRIK1 | MAP1LC3C | 0.607079 | 5 | 0 | 4 |
| GRIK1 | RBFADN | 0.603846 | 4 | 0 | 4 |
| GRIK1 | CYLC2 | 0.600622 | 3 | 0 | 3 |
| GRIK1 | FOXN3-AS2 | 0.59871 | 6 | 0 | 4 |
| GRIK1 | KLHL35 | 0.596814 | 5 | 0 | 5 |
| GRIK1 | FAM66D | 0.596471 | 5 | 0 | 4 |
| GRIK1 | ADCYAP1 | 0.596072 | 3 | 0 | 3 |
| GRIK1 | MTAP | 0.595678 | 4 | 0 | 3 |
| GRIK1 | CDH10 | 0.593777 | 6 | 0 | 5 |
| GRIK1 | HCRTR2 | 0.59091 | 3 | 0 | 3 |
| GRIK1 | OR7E24 | 0.590105 | 6 | 0 | 4 |
For details and further investigation, click here
