| Full name: G protein-coupled receptor 37 | Alias Symbol: EDNRBL|hET(B)R-LP|PAELR | ||
| Type: protein-coding gene | Cytoband: 7q31.33 | ||
| Entrez ID: 2861 | HGNC ID: HGNC:4494 | Ensembl Gene: ENSG00000170775 | OMIM ID: 602583 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR37:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR37 | 2861 | 214586_at | -0.3864 | 0.3970 | |
| GSE20347 | GPR37 | 2861 | 214586_at | -0.1090 | 0.0560 | |
| GSE23400 | GPR37 | 2861 | 214586_at | -0.0386 | 0.0033 | |
| GSE26886 | GPR37 | 2861 | 214586_at | 0.0416 | 0.8075 | |
| GSE29001 | GPR37 | 2861 | 214586_at | -0.0503 | 0.7085 | |
| GSE38129 | GPR37 | 2861 | 214586_at | -0.3002 | 0.0040 | |
| GSE45670 | GPR37 | 2861 | 214586_at | -0.4784 | 0.0671 | |
| GSE63941 | GPR37 | 2861 | 214586_at | -2.0587 | 0.0026 | |
| GSE77861 | GPR37 | 2861 | 214586_at | -0.0794 | 0.3716 | |
| SRP064894 | GPR37 | 2861 | RNAseq | -1.9135 | 0.0000 | |
| SRP133303 | GPR37 | 2861 | RNAseq | 0.1161 | 0.7874 | |
| SRP159526 | GPR37 | 2861 | RNAseq | -2.1510 | 0.0000 | |
| SRP219564 | GPR37 | 2861 | RNAseq | -2.8921 | 0.0000 | |
| TCGA | GPR37 | 2861 | RNAseq | -0.0455 | 0.8534 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by GPR37 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GPR37:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR37 | 2861 | 6 | 2 | 22 | |
| GSE20123 | GPR37 | 2861 | 7 | 2 | 21 | |
| GSE43470 | GPR37 | 2861 | 2 | 4 | 37 | |
| GSE46452 | GPR37 | 2861 | 7 | 2 | 50 | |
| GSE47630 | GPR37 | 2861 | 7 | 4 | 29 | |
| GSE54993 | GPR37 | 2861 | 3 | 5 | 62 | |
| GSE54994 | GPR37 | 2861 | 9 | 7 | 37 | |
| GSE60625 | GPR37 | 2861 | 0 | 0 | 11 | |
| GSE74703 | GPR37 | 2861 | 2 | 4 | 30 | |
| GSE74704 | GPR37 | 2861 | 5 | 2 | 13 | |
| TCGA | GPR37 | 2861 | 27 | 21 | 48 |
Total number of gains: 75; Total number of losses: 53; Total Number of normals: 360.
Somatic mutations of GPR37:
Generating mutation plots.
Highly correlated genes for GPR37:
Showing top 20/38 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR37 | PDE4DIP | 0.737736 | 3 | 0 | 3 |
| GPR37 | HEPH | 0.691184 | 3 | 0 | 3 |
| GPR37 | FAM110B | 0.643216 | 3 | 0 | 3 |
| GPR37 | GRIK1 | 0.630393 | 3 | 0 | 3 |
| GPR37 | PTGIS | 0.591706 | 4 | 0 | 3 |
| GPR37 | SYNC | 0.585025 | 4 | 0 | 4 |
| GPR37 | CPQ | 0.584297 | 4 | 0 | 3 |
| GPR37 | SGMS2 | 0.580075 | 5 | 0 | 4 |
| GPR37 | LINC01140 | 0.56034 | 4 | 0 | 3 |
| GPR37 | ST7-AS1 | 0.55952 | 3 | 0 | 3 |
| GPR37 | VAMP5 | 0.552038 | 3 | 0 | 3 |
| GPR37 | ADD1 | 0.549264 | 5 | 0 | 3 |
| GPR37 | LAPTM4A | 0.541961 | 5 | 0 | 3 |
| GPR37 | MTMR6 | 0.540851 | 5 | 0 | 3 |
| GPR37 | PSIP1 | 0.540696 | 3 | 0 | 3 |
| GPR37 | ACOX2 | 0.536057 | 6 | 0 | 3 |
| GPR37 | IL33 | 0.53422 | 6 | 0 | 3 |
| GPR37 | DLG2 | 0.533539 | 4 | 0 | 3 |
| GPR37 | TMX4 | 0.532714 | 5 | 0 | 3 |
| GPR37 | KAT6B | 0.532447 | 3 | 0 | 3 |
For details and further investigation, click here
