| Full name: sirtuin 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 22933 | HGNC ID: HGNC:10886 | Ensembl Gene: ENSG00000068903 | OMIM ID: 604480 |
| Drug and gene relationship at DGIdb | |||
Expression of SIRT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIRT2 | 22933 | 220605_s_at | -0.1917 | 0.3680 | |
| GSE20347 | SIRT2 | 22933 | 220605_s_at | -0.2468 | 0.0731 | |
| GSE23400 | SIRT2 | 22933 | 220605_s_at | -0.1885 | 0.0000 | |
| GSE26886 | SIRT2 | 22933 | 220605_s_at | -0.1839 | 0.2438 | |
| GSE29001 | SIRT2 | 22933 | 220605_s_at | -0.3965 | 0.0325 | |
| GSE38129 | SIRT2 | 22933 | 220605_s_at | -0.2969 | 0.0040 | |
| GSE45670 | SIRT2 | 22933 | 220605_s_at | -0.1191 | 0.1684 | |
| GSE53622 | SIRT2 | 22933 | 62495 | -0.3463 | 0.0000 | |
| GSE53624 | SIRT2 | 22933 | 105125 | -0.3300 | 0.0000 | |
| GSE63941 | SIRT2 | 22933 | 220605_s_at | 0.3405 | 0.4498 | |
| GSE77861 | SIRT2 | 22933 | 220605_s_at | -0.0538 | 0.8918 | |
| GSE97050 | SIRT2 | 22933 | A_33_P3258946 | 0.3166 | 0.4324 | |
| SRP007169 | SIRT2 | 22933 | RNAseq | -0.8466 | 0.0824 | |
| SRP008496 | SIRT2 | 22933 | RNAseq | -1.1736 | 0.0001 | |
| SRP064894 | SIRT2 | 22933 | RNAseq | -0.0376 | 0.8689 | |
| SRP133303 | SIRT2 | 22933 | RNAseq | -0.1897 | 0.3307 | |
| SRP159526 | SIRT2 | 22933 | RNAseq | -0.3994 | 0.0009 | |
| SRP193095 | SIRT2 | 22933 | RNAseq | -0.1979 | 0.1507 | |
| SRP219564 | SIRT2 | 22933 | RNAseq | -0.3295 | 0.2490 | |
| TCGA | SIRT2 | 22933 | RNAseq | -0.0738 | 0.1421 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SIRT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIRT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIRT2 | 22933 | 7 | 4 | 19 | |
| GSE20123 | SIRT2 | 22933 | 7 | 3 | 20 | |
| GSE43470 | SIRT2 | 22933 | 4 | 10 | 29 | |
| GSE46452 | SIRT2 | 22933 | 47 | 2 | 10 | |
| GSE47630 | SIRT2 | 22933 | 9 | 5 | 26 | |
| GSE54993 | SIRT2 | 22933 | 17 | 3 | 50 | |
| GSE54994 | SIRT2 | 22933 | 6 | 9 | 38 | |
| GSE60625 | SIRT2 | 22933 | 9 | 0 | 2 | |
| GSE74703 | SIRT2 | 22933 | 4 | 6 | 26 | |
| GSE74704 | SIRT2 | 22933 | 7 | 1 | 12 | |
| TCGA | SIRT2 | 22933 | 14 | 16 | 66 |
Total number of gains: 131; Total number of losses: 59; Total Number of normals: 298.
Somatic mutations of SIRT2:
Generating mutation plots.
Highly correlated genes for SIRT2:
Showing top 20/295 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIRT2 | GRIK2 | 0.746399 | 3 | 0 | 3 |
| SIRT2 | STAC | 0.725431 | 3 | 0 | 3 |
| SIRT2 | CCDC80 | 0.693738 | 3 | 0 | 3 |
| SIRT2 | SEC31B | 0.68741 | 4 | 0 | 4 |
| SIRT2 | FCGRT | 0.676091 | 3 | 0 | 3 |
| SIRT2 | ZFYVE9 | 0.672919 | 4 | 0 | 3 |
| SIRT2 | PTGER3 | 0.663695 | 3 | 0 | 3 |
| SIRT2 | SYTL4 | 0.663491 | 3 | 0 | 3 |
| SIRT2 | HOXB3 | 0.662667 | 3 | 0 | 3 |
| SIRT2 | JAM3 | 0.652225 | 3 | 0 | 3 |
| SIRT2 | KAT7 | 0.646783 | 3 | 0 | 3 |
| SIRT2 | RABEP2 | 0.642368 | 4 | 0 | 3 |
| SIRT2 | SELP | 0.639429 | 6 | 0 | 4 |
| SIRT2 | C11orf68 | 0.637964 | 4 | 0 | 3 |
| SIRT2 | RSPO3 | 0.637469 | 3 | 0 | 3 |
| SIRT2 | DDR2 | 0.635967 | 3 | 0 | 3 |
| SIRT2 | KRTAP5-8 | 0.634651 | 3 | 0 | 3 |
| SIRT2 | CAPN11 | 0.632784 | 5 | 0 | 5 |
| SIRT2 | CYB5R3 | 0.631032 | 3 | 0 | 3 |
| SIRT2 | FXR2 | 0.626577 | 4 | 0 | 3 |
For details and further investigation, click here
