| Full name: glutamate metabotropic receptor 5 | Alias Symbol: MGLUR5|GPRC1E|mGlu5|PPP1R86 | ||
| Type: protein-coding gene | Cytoband: 11q14.2-q14.3 | ||
| Entrez ID: 2915 | HGNC ID: HGNC:4597 | Ensembl Gene: ENSG00000168959 | OMIM ID: 604102 |
| Drug and gene relationship at DGIdb | |||
GRM5 involved pathways:
Expression of GRM5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRM5 | 2915 | 1565389_s_at | -0.3155 | 0.1332 | |
| GSE20347 | GRM5 | 2915 | 207235_s_at | -0.0309 | 0.6591 | |
| GSE23400 | GRM5 | 2915 | 207235_s_at | -0.0650 | 0.0321 | |
| GSE26886 | GRM5 | 2915 | 1565389_s_at | 0.0546 | 0.7588 | |
| GSE29001 | GRM5 | 2915 | 214217_at | 0.1448 | 0.3488 | |
| GSE38129 | GRM5 | 2915 | 214217_at | 0.0195 | 0.6967 | |
| GSE45670 | GRM5 | 2915 | 1565389_s_at | -0.1751 | 0.1466 | |
| GSE53622 | GRM5 | 2915 | 49678 | 0.4211 | 0.0000 | |
| GSE53624 | GRM5 | 2915 | 49678 | 0.4590 | 0.0000 | |
| GSE63941 | GRM5 | 2915 | 1565389_s_at | 0.4718 | 0.0266 | |
| GSE77861 | GRM5 | 2915 | 1565389_s_at | -0.1231 | 0.4725 | |
| TCGA | GRM5 | 2915 | RNAseq | 1.5682 | 0.0103 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GRM5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRM5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRM5 | 2915 | 3 | 10 | 17 | |
| GSE20123 | GRM5 | 2915 | 3 | 10 | 17 | |
| GSE43470 | GRM5 | 2915 | 3 | 4 | 36 | |
| GSE46452 | GRM5 | 2915 | 6 | 23 | 30 | |
| GSE47630 | GRM5 | 2915 | 2 | 19 | 19 | |
| GSE54993 | GRM5 | 2915 | 8 | 2 | 60 | |
| GSE54994 | GRM5 | 2915 | 5 | 19 | 29 | |
| GSE60625 | GRM5 | 2915 | 0 | 4 | 7 | |
| GSE74703 | GRM5 | 2915 | 2 | 3 | 31 | |
| GSE74704 | GRM5 | 2915 | 3 | 6 | 11 | |
| TCGA | GRM5 | 2915 | 16 | 38 | 42 |
Total number of gains: 51; Total number of losses: 138; Total Number of normals: 299.
Somatic mutations of GRM5:
Generating mutation plots.
Highly correlated genes for GRM5:
Showing top 20/88 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRM5 | SRY | 0.679061 | 3 | 0 | 3 |
| GRM5 | AGRP | 0.674679 | 4 | 0 | 4 |
| GRM5 | RIT2 | 0.669867 | 3 | 0 | 3 |
| GRM5 | DNAH9 | 0.657357 | 3 | 0 | 3 |
| GRM5 | TRIM10 | 0.638481 | 4 | 0 | 3 |
| GRM5 | KRTAP4-7 | 0.624467 | 3 | 0 | 3 |
| GRM5 | KRT72 | 0.620829 | 3 | 0 | 3 |
| GRM5 | USH1C | 0.618417 | 3 | 0 | 3 |
| GRM5 | IMPG1 | 0.616584 | 3 | 0 | 3 |
| GRM5 | SLC26A1 | 0.615228 | 3 | 0 | 3 |
| GRM5 | SERPINA10 | 0.611737 | 4 | 0 | 3 |
| GRM5 | EFCC1 | 0.601137 | 3 | 0 | 3 |
| GRM5 | HNF4A | 0.598675 | 3 | 0 | 3 |
| GRM5 | TNR | 0.595687 | 4 | 0 | 3 |
| GRM5 | CYP2A7 | 0.59103 | 3 | 0 | 3 |
| GRM5 | PAPPA2 | 0.588273 | 3 | 0 | 3 |
| GRM5 | INSL6 | 0.588217 | 3 | 0 | 3 |
| GRM5 | CLDN9 | 0.587298 | 5 | 0 | 3 |
| GRM5 | GUCY2D | 0.585692 | 4 | 0 | 3 |
| GRM5 | SCNN1G | 0.58563 | 5 | 0 | 3 |
For details and further investigation, click here
