| Full name: guanylate cyclase 2D, retinal | Alias Symbol: retGC|RETGC-1|ROS-GC1|CYGD|LCA1 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 3000 | HGNC ID: HGNC:4689 | Ensembl Gene: ENSG00000132518 | OMIM ID: 600179 |
| Drug and gene relationship at DGIdb | |||
GUCY2D involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04740 | Olfactory transduction |
Expression of GUCY2D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GUCY2D | 3000 | 207884_at | -0.3201 | 0.2189 | |
| GSE20347 | GUCY2D | 3000 | 207884_at | -0.2133 | 0.0124 | |
| GSE23400 | GUCY2D | 3000 | 207884_at | -0.2699 | 0.0000 | |
| GSE26886 | GUCY2D | 3000 | 207884_at | 0.0414 | 0.8121 | |
| GSE29001 | GUCY2D | 3000 | 207884_at | -0.2387 | 0.2498 | |
| GSE38129 | GUCY2D | 3000 | 207884_at | -0.2152 | 0.0096 | |
| GSE45670 | GUCY2D | 3000 | 207884_at | -0.1160 | 0.3882 | |
| GSE53622 | GUCY2D | 3000 | 123511 | 0.6529 | 0.0000 | |
| GSE53624 | GUCY2D | 3000 | 123511 | 0.4926 | 0.0000 | |
| GSE63941 | GUCY2D | 3000 | 207884_at | 0.1972 | 0.4209 | |
| GSE77861 | GUCY2D | 3000 | 207884_at | -0.1238 | 0.3889 | |
| SRP133303 | GUCY2D | 3000 | RNAseq | -0.1401 | 0.7073 | |
| SRP159526 | GUCY2D | 3000 | RNAseq | -1.4588 | 0.0129 | |
| TCGA | GUCY2D | 3000 | RNAseq | 1.3494 | 0.0177 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by GUCY2D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GUCY2D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GUCY2D | 3000 | 4 | 2 | 24 | |
| GSE20123 | GUCY2D | 3000 | 4 | 3 | 23 | |
| GSE43470 | GUCY2D | 3000 | 1 | 6 | 36 | |
| GSE46452 | GUCY2D | 3000 | 34 | 1 | 24 | |
| GSE47630 | GUCY2D | 3000 | 7 | 1 | 32 | |
| GSE54993 | GUCY2D | 3000 | 4 | 3 | 63 | |
| GSE54994 | GUCY2D | 3000 | 5 | 8 | 40 | |
| GSE60625 | GUCY2D | 3000 | 4 | 0 | 7 | |
| GSE74703 | GUCY2D | 3000 | 1 | 3 | 32 | |
| GSE74704 | GUCY2D | 3000 | 2 | 1 | 17 | |
| TCGA | GUCY2D | 3000 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of GUCY2D:
Generating mutation plots.
Highly correlated genes for GUCY2D:
Showing top 20/399 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GUCY2D | ADAM30 | 0.707455 | 3 | 0 | 3 |
| GUCY2D | AGTR2 | 0.692516 | 3 | 0 | 3 |
| GUCY2D | IL9R | 0.671946 | 3 | 0 | 3 |
| GUCY2D | FNDC8 | 0.670523 | 3 | 0 | 3 |
| GUCY2D | PIK3R5 | 0.66701 | 3 | 0 | 3 |
| GUCY2D | MRGPRX2 | 0.663498 | 3 | 0 | 3 |
| GUCY2D | MYO1A | 0.658551 | 4 | 0 | 3 |
| GUCY2D | INO80D | 0.653383 | 4 | 0 | 4 |
| GUCY2D | ASMT | 0.651225 | 4 | 0 | 4 |
| GUCY2D | MUC3B | 0.650876 | 4 | 0 | 3 |
| GUCY2D | KAZALD1 | 0.645601 | 3 | 0 | 3 |
| GUCY2D | EVPLL | 0.641968 | 3 | 0 | 3 |
| GUCY2D | HOXC5 | 0.636225 | 4 | 0 | 3 |
| GUCY2D | TMPRSS6 | 0.635202 | 5 | 0 | 5 |
| GUCY2D | PRL | 0.632151 | 4 | 0 | 3 |
| GUCY2D | CAPN10 | 0.631792 | 3 | 0 | 3 |
| GUCY2D | CBR3-AS1 | 0.630662 | 3 | 0 | 3 |
| GUCY2D | BLK | 0.628722 | 3 | 0 | 3 |
| GUCY2D | CCDC120 | 0.628542 | 3 | 0 | 3 |
| GUCY2D | DRD5 | 0.624965 | 3 | 0 | 3 |
For details and further investigation, click here
