KMT2B

 

Full name: lysine methyltransferase 2B Alias Symbol: KIAA0304|MLL2|TRX2|HRX2|WBP7|MLL1B|MLL4|CXXC10
Type: protein-coding gene Cytoband: 19q13.12
Entrez ID: 9757 HGNC ID: HGNC:15840 Ensembl Gene: ENSG00000272333 OMIM ID: 606834
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 15/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of KMT2B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KMT2B 9757 203419_at 0.3785 0.3994
GSE20347 KMT2B 9757 203419_at 0.1346 0.5244
GSE23400 KMT2B 9757 203419_at 0.1320 0.0516
GSE26886 KMT2B 9757 203419_at 0.2542 0.0897
GSE29001 KMT2B 9757 203419_at 0.1982 0.4168
GSE38129 KMT2B 9757 203419_at 0.1897 0.1163
GSE45670 KMT2B 9757 203419_at 0.1122 0.4347
GSE53622 KMT2B 9757 111571 0.0184 0.7801
GSE53624 KMT2B 9757 111571 -0.2977 0.0054
GSE63941 KMT2B 9757 203419_at 0.5231 0.2223
GSE77861 KMT2B 9757 203419_at 0.5775 0.0692
SRP007169 KMT2B 9757 RNAseq 2.0131 0.0069
SRP008496 KMT2B 9757 RNAseq 1.2412 0.0145
SRP064894 KMT2B 9757 RNAseq 0.1655 0.4737
SRP133303 KMT2B 9757 RNAseq 0.0272 0.8958
SRP159526 KMT2B 9757 RNAseq 0.2593 0.2218
SRP193095 KMT2B 9757 RNAseq 0.4305 0.0202
SRP219564 KMT2B 9757 RNAseq -0.1202 0.7132

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by KMT2B expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of KMT2B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KMT2B 9757 7 4 19
GSE20123 KMT2B 9757 7 3 20
GSE43470 KMT2B 9757 3 7 33
GSE46452 KMT2B 9757 48 1 10
GSE47630 KMT2B 9757 9 5 26
GSE54993 KMT2B 9757 17 3 50
GSE54994 KMT2B 9757 7 9 37
GSE60625 KMT2B 9757 9 0 2
GSE74703 KMT2B 9757 3 4 29
GSE74704 KMT2B 9757 6 1 13
TCGA KMT2B 9757 22 10 64

Total number of gains: 138; Total number of losses: 47; Total Number of normals: 303.  

 

Somatic mutations of KMT2B:

 

Generating mutation plots.

 

Highly correlated genes for KMT2B:

 

Showing top 20/190 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KMT2BGSDMB0.84423303
KMT2BGATAD2B0.717927303
KMT2BCHD30.717532403
KMT2BCOL7A10.705494303
KMT2BUBAP2L0.701194303
KMT2BANKRD270.685101707
KMT2BEWSR10.680426303
KMT2BCYHR10.676253303
KMT2BHELZ0.674144303
KMT2BLRFN10.664237303
KMT2BALPL0.652165303
KMT2BPRR120.64829303
KMT2BTNRC180.646027404
KMT2BDOT1L0.641126303
KMT2BPDCD2L0.64006504
KMT2BALKBH60.639366504
KMT2BMED220.63474505
KMT2BDAG10.634469303
KMT2BSUPT5H0.634339905
KMT2BCEP2500.633532303

For details and further investigation, click here