| Full name: ribonuclease H2 subunit B | Alias Symbol: FLJ11712 | ||
| Type: protein-coding gene | Cytoband: 13q14.3 | ||
| Entrez ID: 79621 | HGNC ID: HGNC:25671 | Ensembl Gene: ENSG00000136104 | OMIM ID: 610326 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RNASEH2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RNASEH2B | 79621 | 215040_at | 0.2397 | 0.4237 | |
| GSE20347 | RNASEH2B | 79621 | 215040_at | 0.1721 | 0.1401 | |
| GSE23400 | RNASEH2B | 79621 | 215040_at | 0.1474 | 0.0004 | |
| GSE26886 | RNASEH2B | 79621 | 229210_at | 0.3830 | 0.0435 | |
| GSE29001 | RNASEH2B | 79621 | 215040_at | -0.0535 | 0.8628 | |
| GSE38129 | RNASEH2B | 79621 | 215040_at | -0.0453 | 0.7844 | |
| GSE45670 | RNASEH2B | 79621 | 229210_at | -0.2457 | 0.2904 | |
| GSE53622 | RNASEH2B | 79621 | 43075 | 0.1412 | 0.0550 | |
| GSE53624 | RNASEH2B | 79621 | 43075 | 0.4336 | 0.0000 | |
| GSE63941 | RNASEH2B | 79621 | 215040_at | 0.1507 | 0.5485 | |
| GSE77861 | RNASEH2B | 79621 | 229210_at | 0.0153 | 0.9395 | |
| GSE97050 | RNASEH2B | 79621 | A_33_P3213857 | -0.2072 | 0.4465 | |
| SRP007169 | RNASEH2B | 79621 | RNAseq | -0.3130 | 0.4994 | |
| SRP008496 | RNASEH2B | 79621 | RNAseq | 0.1957 | 0.6008 | |
| SRP064894 | RNASEH2B | 79621 | RNAseq | 0.4252 | 0.0256 | |
| SRP133303 | RNASEH2B | 79621 | RNAseq | -0.0003 | 0.9986 | |
| SRP159526 | RNASEH2B | 79621 | RNAseq | -0.2331 | 0.3655 | |
| SRP193095 | RNASEH2B | 79621 | RNAseq | -0.0287 | 0.8511 | |
| SRP219564 | RNASEH2B | 79621 | RNAseq | -0.1667 | 0.6553 | |
| TCGA | RNASEH2B | 79621 | RNAseq | 0.0512 | 0.4100 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RNASEH2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RNASEH2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RNASEH2B | 79621 | 1 | 12 | 17 | |
| GSE20123 | RNASEH2B | 79621 | 1 | 11 | 18 | |
| GSE43470 | RNASEH2B | 79621 | 3 | 13 | 27 | |
| GSE46452 | RNASEH2B | 79621 | 0 | 32 | 27 | |
| GSE47630 | RNASEH2B | 79621 | 2 | 27 | 11 | |
| GSE54993 | RNASEH2B | 79621 | 12 | 2 | 56 | |
| GSE54994 | RNASEH2B | 79621 | 1 | 15 | 37 | |
| GSE60625 | RNASEH2B | 79621 | 0 | 3 | 8 | |
| GSE74703 | RNASEH2B | 79621 | 3 | 10 | 23 | |
| GSE74704 | RNASEH2B | 79621 | 0 | 8 | 12 | |
| TCGA | RNASEH2B | 79621 | 9 | 37 | 50 |
Total number of gains: 32; Total number of losses: 170; Total Number of normals: 286.
Somatic mutations of RNASEH2B:
Generating mutation plots.
Highly correlated genes for RNASEH2B:
Showing top 20/550 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RNASEH2B | SGSH | 0.822515 | 3 | 0 | 3 |
| RNASEH2B | FCF1 | 0.809443 | 3 | 0 | 3 |
| RNASEH2B | MRPS6 | 0.798766 | 3 | 0 | 3 |
| RNASEH2B | EXOC8 | 0.796652 | 3 | 0 | 3 |
| RNASEH2B | NUDT19 | 0.792717 | 3 | 0 | 3 |
| RNASEH2B | ZNF789 | 0.781034 | 3 | 0 | 3 |
| RNASEH2B | CPSF6 | 0.778632 | 3 | 0 | 3 |
| RNASEH2B | HYLS1 | 0.770139 | 3 | 0 | 3 |
| RNASEH2B | MAK16 | 0.759192 | 3 | 0 | 3 |
| RNASEH2B | ARHGAP35 | 0.7583 | 3 | 0 | 3 |
| RNASEH2B | PPP1R16A | 0.757589 | 3 | 0 | 3 |
| RNASEH2B | TRMT2B | 0.752957 | 3 | 0 | 3 |
| RNASEH2B | RRS1 | 0.743677 | 3 | 0 | 3 |
| RNASEH2B | TMEM181 | 0.74324 | 3 | 0 | 3 |
| RNASEH2B | ZNF22 | 0.739717 | 4 | 0 | 4 |
| RNASEH2B | TPR | 0.736816 | 4 | 0 | 3 |
| RNASEH2B | METTL3 | 0.73636 | 3 | 0 | 3 |
| RNASEH2B | KLHDC10 | 0.733997 | 3 | 0 | 3 |
| RNASEH2B | ZNF268 | 0.733036 | 3 | 0 | 3 |
| RNASEH2B | PSMB4 | 0.732048 | 4 | 0 | 4 |
For details and further investigation, click here
