GSK3B

 

Full name: glycogen synthase kinase 3 beta Alias Symbol: 
Type: protein-coding gene Cytoband: 3q13.33
Entrez ID: 2932 HGNC ID: HGNC:4617 Ensembl Gene: ENSG00000082701 OMIM ID: 605004
Drug and gene relationship at DGIdb
Screen Evidence:

 

GSK3B involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04062Chemokine signaling pathway
hsa04110Cell cycle
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa04360Axon guidance
hsa04390Hippo signaling pathway
hsa04510Focal adhesion
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04728Dopaminergic synapse
hsa04910Insulin signaling pathway
hsa04916Melanogenesis
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa05010Alzheimer's disease
hsa05160Hepatitis C
hsa05162Measles
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05217Basal cell carcinoma

 

Expression of GSK3B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GSK3B 2932 226191_at 0.8778 0.0559
GSE20347 GSK3B 2932 209945_s_at 0.3677 0.0206
GSE23400 GSK3B 2932 209945_s_at 0.5533 0.0000
GSE26886 GSK3B 2932 226191_at 0.0014 0.9938
GSE29001 GSK3B 2932 209945_s_at 0.2874 0.4861
GSE38129 GSK3B 2932 209945_s_at 0.4265 0.0740
GSE45670 GSK3B 2932 226191_at 0.5072 0.0004
GSE53622 GSK3B 2932 29585 0.4793 0.0000
GSE53624 GSK3B 2932 101787 0.5582 0.0000
GSE63941 GSK3B 2932 226191_at -0.2697 0.5524
GSE77861 GSK3B 2932 226191_at 0.0933 0.8441
GSE97050 GSK3B 2932 A_23_P251342 0.4778 0.1920
SRP007169 GSK3B 2932 RNAseq 0.6150 0.0622
SRP008496 GSK3B 2932 RNAseq 0.8959 0.0010
SRP064894 GSK3B 2932 RNAseq 0.3842 0.0585
SRP133303 GSK3B 2932 RNAseq 0.5030 0.0006
SRP159526 GSK3B 2932 RNAseq 0.2457 0.4107
SRP193095 GSK3B 2932 RNAseq 0.4906 0.0000
SRP219564 GSK3B 2932 RNAseq -0.1636 0.6149
TCGA GSK3B 2932 RNAseq 0.0773 0.1720

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GSK3B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GSK3B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GSK3B 2932 18 0 12
GSE20123 GSK3B 2932 18 0 12
GSE43470 GSK3B 2932 21 1 21
GSE46452 GSK3B 2932 14 5 40
GSE47630 GSK3B 2932 16 5 19
GSE54993 GSK3B 2932 2 6 62
GSE54994 GSK3B 2932 30 4 19
GSE60625 GSK3B 2932 0 6 5
GSE74703 GSK3B 2932 17 1 18
GSE74704 GSK3B 2932 13 0 7
TCGA GSK3B 2932 53 7 36

Total number of gains: 202; Total number of losses: 35; Total Number of normals: 251.  

 

Somatic mutations of GSK3B:

 

Generating mutation plots.

 

Highly correlated genes for GSK3B:

 

Showing top 20/874 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GSK3BKBTBD60.787529303
GSK3BGPR1600.770465303
GSK3BFLYWCH20.759099303
GSK3BPRPF4B0.754895303
GSK3BTMEM1600.750485303
GSK3BCOMMD20.739971505
GSK3BLRRC580.737777605
GSK3BZBTB90.736692403
GSK3BMAP4K40.728061303
GSK3BRPN10.725198909
GSK3BDUSP230.72337303
GSK3BKDM1B0.72031404
GSK3BNOC2L0.72003303
GSK3BUHMK10.719417403
GSK3BSLC39A30.717241303
GSK3BFCHSD20.71568303
GSK3BEBNA1BP20.714189303
GSK3BATG4C0.713138303
GSK3BWDR770.712763303
GSK3BACAD90.71271404

For details and further investigation, click here