| Full name: lysine demethylase 1B | Alias Symbol: FLJ34109|FLJ33898|dJ298J15.2|bA204B7.3|FLJ43328|LSD2 | ||
| Type: protein-coding gene | Cytoband: 6p22.3 | ||
| Entrez ID: 221656 | HGNC ID: HGNC:21577 | Ensembl Gene: ENSG00000165097 | OMIM ID: 613081 |
| Drug and gene relationship at DGIdb | |||
Expression of KDM1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KDM1B | 221656 | 227021_at | 1.0417 | 0.0250 | |
| GSE26886 | KDM1B | 221656 | 227021_at | -0.5454 | 0.1133 | |
| GSE45670 | KDM1B | 221656 | 227021_at | 0.4958 | 0.0517 | |
| GSE53622 | KDM1B | 221656 | 37063 | 0.4987 | 0.0000 | |
| GSE53624 | KDM1B | 221656 | 37063 | 0.3017 | 0.0000 | |
| GSE63941 | KDM1B | 221656 | 227021_at | 0.5385 | 0.4728 | |
| GSE77861 | KDM1B | 221656 | 227021_at | 0.7820 | 0.0924 | |
| GSE97050 | KDM1B | 221656 | A_23_P145035 | 0.5580 | 0.1415 | |
| SRP007169 | KDM1B | 221656 | RNAseq | 1.1405 | 0.0044 | |
| SRP008496 | KDM1B | 221656 | RNAseq | 1.1553 | 0.0000 | |
| SRP064894 | KDM1B | 221656 | RNAseq | 0.0797 | 0.7426 | |
| SRP133303 | KDM1B | 221656 | RNAseq | 0.3421 | 0.0916 | |
| SRP159526 | KDM1B | 221656 | RNAseq | 0.3557 | 0.0483 | |
| SRP193095 | KDM1B | 221656 | RNAseq | 0.1198 | 0.2619 | |
| SRP219564 | KDM1B | 221656 | RNAseq | 0.0346 | 0.8865 | |
| TCGA | KDM1B | 221656 | RNAseq | 0.2519 | 0.0001 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by KDM1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KDM1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KDM1B | 221656 | 2 | 6 | 22 | |
| GSE20123 | KDM1B | 221656 | 2 | 6 | 22 | |
| GSE43470 | KDM1B | 221656 | 9 | 0 | 34 | |
| GSE46452 | KDM1B | 221656 | 1 | 10 | 48 | |
| GSE47630 | KDM1B | 221656 | 7 | 7 | 26 | |
| GSE54993 | KDM1B | 221656 | 1 | 1 | 68 | |
| GSE54994 | KDM1B | 221656 | 10 | 4 | 39 | |
| GSE60625 | KDM1B | 221656 | 0 | 1 | 10 | |
| GSE74703 | KDM1B | 221656 | 8 | 0 | 28 | |
| GSE74704 | KDM1B | 221656 | 1 | 2 | 17 | |
| TCGA | KDM1B | 221656 | 16 | 26 | 54 |
Total number of gains: 57; Total number of losses: 63; Total Number of normals: 368.
Somatic mutations of KDM1B:
Generating mutation plots.
Highly correlated genes for KDM1B:
Showing top 20/695 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KDM1B | TMTC4 | 0.802759 | 3 | 0 | 3 |
| KDM1B | PPP2R1B | 0.7874 | 3 | 0 | 3 |
| KDM1B | F2RL1 | 0.780612 | 3 | 0 | 3 |
| KDM1B | EAF2 | 0.777414 | 3 | 0 | 3 |
| KDM1B | FAM111B | 0.768637 | 3 | 0 | 3 |
| KDM1B | ARHGEF11 | 0.765564 | 3 | 0 | 3 |
| KDM1B | SPSB2 | 0.762035 | 3 | 0 | 3 |
| KDM1B | PNPLA6 | 0.760119 | 3 | 0 | 3 |
| KDM1B | WDR3 | 0.752583 | 3 | 0 | 3 |
| KDM1B | CCNK | 0.749257 | 3 | 0 | 3 |
| KDM1B | CCT5 | 0.746884 | 3 | 0 | 3 |
| KDM1B | TATDN2 | 0.743197 | 3 | 0 | 3 |
| KDM1B | PRR3 | 0.742732 | 4 | 0 | 4 |
| KDM1B | SFT2D2 | 0.740532 | 3 | 0 | 3 |
| KDM1B | KIF16B | 0.740365 | 3 | 0 | 3 |
| KDM1B | CCDC86 | 0.735245 | 4 | 0 | 4 |
| KDM1B | SEC61A1 | 0.730872 | 4 | 0 | 3 |
| KDM1B | SPNS1 | 0.721785 | 3 | 0 | 3 |
| KDM1B | GSK3B | 0.72031 | 4 | 0 | 4 |
| KDM1B | CXXC1 | 0.719585 | 3 | 0 | 3 |
For details and further investigation, click here
