| Full name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Alias Symbol: GBP|LCEH|LCHAD|MTPA | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 3030 | HGNC ID: HGNC:4801 | Ensembl Gene: ENSG00000084754 | OMIM ID: 600890 |
| Drug and gene relationship at DGIdb | |||
Expression of HADHA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HADHA | 3030 | 208631_s_at | -0.3457 | 0.5220 | |
| GSE20347 | HADHA | 3030 | 208630_at | -0.4993 | 0.0004 | |
| GSE23400 | HADHA | 3030 | 208631_s_at | -0.3319 | 0.0000 | |
| GSE26886 | HADHA | 3030 | 208630_at | -0.3507 | 0.0122 | |
| GSE29001 | HADHA | 3030 | 208630_at | -0.5650 | 0.0014 | |
| GSE38129 | HADHA | 3030 | 208630_at | -0.4518 | 0.0000 | |
| GSE45670 | HADHA | 3030 | 208630_at | -0.2976 | 0.0146 | |
| GSE53622 | HADHA | 3030 | 132080 | -0.6008 | 0.0000 | |
| GSE53624 | HADHA | 3030 | 132080 | -0.6332 | 0.0000 | |
| GSE63941 | HADHA | 3030 | 208631_s_at | 0.3831 | 0.2601 | |
| GSE77861 | HADHA | 3030 | 208631_s_at | -0.3298 | 0.1409 | |
| GSE97050 | HADHA | 3030 | A_24_P242688 | -0.2818 | 0.2581 | |
| SRP007169 | HADHA | 3030 | RNAseq | -0.9565 | 0.0218 | |
| SRP008496 | HADHA | 3030 | RNAseq | -0.6652 | 0.0024 | |
| SRP064894 | HADHA | 3030 | RNAseq | -0.4215 | 0.0034 | |
| SRP133303 | HADHA | 3030 | RNAseq | -0.2940 | 0.0169 | |
| SRP159526 | HADHA | 3030 | RNAseq | -0.2999 | 0.1009 | |
| SRP193095 | HADHA | 3030 | RNAseq | -0.5317 | 0.0000 | |
| SRP219564 | HADHA | 3030 | RNAseq | -0.5692 | 0.0205 | |
| TCGA | HADHA | 3030 | RNAseq | -0.1298 | 0.0010 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HADHA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HADHA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HADHA | 3030 | 11 | 2 | 17 | |
| GSE20123 | HADHA | 3030 | 11 | 2 | 17 | |
| GSE43470 | HADHA | 3030 | 3 | 1 | 39 | |
| GSE46452 | HADHA | 3030 | 3 | 4 | 52 | |
| GSE47630 | HADHA | 3030 | 8 | 0 | 32 | |
| GSE54993 | HADHA | 3030 | 0 | 6 | 64 | |
| GSE54994 | HADHA | 3030 | 10 | 0 | 43 | |
| GSE60625 | HADHA | 3030 | 0 | 3 | 8 | |
| GSE74703 | HADHA | 3030 | 3 | 0 | 33 | |
| GSE74704 | HADHA | 3030 | 9 | 1 | 10 | |
| TCGA | HADHA | 3030 | 37 | 2 | 57 |
Total number of gains: 95; Total number of losses: 21; Total Number of normals: 372.
Somatic mutations of HADHA:
Generating mutation plots.
Highly correlated genes for HADHA:
Showing top 20/904 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HADHA | ADAMTSL5 | 0.73653 | 3 | 0 | 3 |
| HADHA | UBE4B | 0.736456 | 3 | 0 | 3 |
| HADHA | KBTBD3 | 0.714055 | 3 | 0 | 3 |
| HADHA | HADHB | 0.705736 | 12 | 0 | 11 |
| HADHA | PSMD7 | 0.70072 | 3 | 0 | 3 |
| HADHA | GPRASP2 | 0.690611 | 3 | 0 | 3 |
| HADHA | RAD50 | 0.690061 | 4 | 0 | 4 |
| HADHA | TMOD2 | 0.688955 | 3 | 0 | 3 |
| HADHA | BRK1 | 0.676588 | 6 | 0 | 6 |
| HADHA | YPEL3 | 0.674775 | 3 | 0 | 3 |
| HADHA | PITHD1 | 0.671496 | 5 | 0 | 4 |
| HADHA | SMIM12 | 0.671438 | 3 | 0 | 3 |
| HADHA | KPNA4 | 0.670805 | 4 | 0 | 3 |
| HADHA | PTCD2 | 0.669463 | 4 | 0 | 3 |
| HADHA | CCDC159 | 0.667474 | 3 | 0 | 3 |
| HADHA | RGS7BP | 0.665214 | 3 | 0 | 3 |
| HADHA | CTTNBP2NL | 0.660319 | 6 | 0 | 6 |
| HADHA | CYYR1 | 0.657918 | 4 | 0 | 4 |
| HADHA | RPF1 | 0.657633 | 3 | 0 | 3 |
| HADHA | UGP2 | 0.651932 | 9 | 0 | 8 |
For details and further investigation, click here
