| Full name: karyopherin subunit alpha 4 | Alias Symbol: QIP1|SRP3|IPOA3|MGC12217|MGC26703 | ||
| Type: protein-coding gene | Cytoband: 3q25.33 | ||
| Entrez ID: 3840 | HGNC ID: HGNC:6397 | Ensembl Gene: ENSG00000186432 | OMIM ID: 602970 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KPNA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KPNA4 | 3840 | 225268_at | 0.0385 | 0.9521 | |
| GSE20347 | KPNA4 | 3840 | 213567_at | -0.6293 | 0.0002 | |
| GSE23400 | KPNA4 | 3840 | 209653_at | 0.2518 | 0.0065 | |
| GSE26886 | KPNA4 | 3840 | 225268_at | 0.3272 | 0.1270 | |
| GSE29001 | KPNA4 | 3840 | 213567_at | -0.1206 | 0.7640 | |
| GSE38129 | KPNA4 | 3840 | 213567_at | -0.5548 | 0.0000 | |
| GSE45670 | KPNA4 | 3840 | 225268_at | 0.0129 | 0.9279 | |
| GSE53622 | KPNA4 | 3840 | 30216 | -0.2279 | 0.0000 | |
| GSE53624 | KPNA4 | 3840 | 59623 | 0.0369 | 0.4300 | |
| GSE63941 | KPNA4 | 3840 | 225268_at | -0.0878 | 0.8827 | |
| GSE77861 | KPNA4 | 3840 | 225268_at | 0.0013 | 0.9968 | |
| GSE97050 | KPNA4 | A_19_P00802654 | -0.4430 | 0.2087 | ||
| SRP007169 | KPNA4 | 3840 | RNAseq | -0.5873 | 0.0724 | |
| SRP008496 | KPNA4 | 3840 | RNAseq | -0.3636 | 0.0414 | |
| SRP064894 | KPNA4 | 3840 | RNAseq | -0.1634 | 0.2641 | |
| SRP133303 | KPNA4 | 3840 | RNAseq | 0.3704 | 0.0098 | |
| SRP159526 | KPNA4 | 3840 | RNAseq | 0.5283 | 0.0356 | |
| SRP193095 | KPNA4 | 3840 | RNAseq | 0.0969 | 0.4362 | |
| SRP219564 | KPNA4 | 3840 | RNAseq | -0.2670 | 0.4480 | |
| TCGA | KPNA4 | 3840 | RNAseq | 0.1103 | 0.0129 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KPNA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KPNA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KPNA4 | 3840 | 22 | 0 | 8 | |
| GSE20123 | KPNA4 | 3840 | 22 | 0 | 8 | |
| GSE43470 | KPNA4 | 3840 | 23 | 0 | 20 | |
| GSE46452 | KPNA4 | 3840 | 18 | 2 | 39 | |
| GSE47630 | KPNA4 | 3840 | 19 | 3 | 18 | |
| GSE54993 | KPNA4 | 3840 | 1 | 11 | 58 | |
| GSE54994 | KPNA4 | 3840 | 38 | 1 | 14 | |
| GSE60625 | KPNA4 | 3840 | 0 | 6 | 5 | |
| GSE74703 | KPNA4 | 3840 | 20 | 0 | 16 | |
| GSE74704 | KPNA4 | 3840 | 14 | 0 | 6 | |
| TCGA | KPNA4 | 3840 | 77 | 0 | 19 |
Total number of gains: 254; Total number of losses: 23; Total Number of normals: 211.
Somatic mutations of KPNA4:
Generating mutation plots.
Highly correlated genes for KPNA4:
Showing top 20/347 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KPNA4 | LARP1B | 0.77014 | 3 | 0 | 3 |
| KPNA4 | LUC7L2 | 0.767439 | 3 | 0 | 3 |
| KPNA4 | SESN1 | 0.749033 | 3 | 0 | 3 |
| KPNA4 | ZFYVE9 | 0.742251 | 3 | 0 | 3 |
| KPNA4 | ZNF83 | 0.727835 | 3 | 0 | 3 |
| KPNA4 | SLC30A9 | 0.72586 | 3 | 0 | 3 |
| KPNA4 | RRAGC | 0.713684 | 4 | 0 | 3 |
| KPNA4 | SLC37A3 | 0.702249 | 3 | 0 | 3 |
| KPNA4 | CITED2 | 0.70058 | 3 | 0 | 3 |
| KPNA4 | RWDD2B | 0.69809 | 3 | 0 | 3 |
| KPNA4 | GABPA | 0.692755 | 3 | 0 | 3 |
| KPNA4 | FAM8A1 | 0.691426 | 5 | 0 | 5 |
| KPNA4 | PTPN13 | 0.690706 | 3 | 0 | 3 |
| KPNA4 | GPBP1L1 | 0.687953 | 4 | 0 | 3 |
| KPNA4 | SUN1 | 0.6863 | 3 | 0 | 3 |
| KPNA4 | LMLN | 0.685597 | 3 | 0 | 3 |
| KPNA4 | MCCC1 | 0.683482 | 4 | 0 | 3 |
| KPNA4 | LNX2 | 0.679315 | 3 | 0 | 3 |
| KPNA4 | CCNT1 | 0.677646 | 3 | 0 | 3 |
| KPNA4 | C1orf174 | 0.675504 | 3 | 0 | 3 |
For details and further investigation, click here
