| Full name: hemoglobin subunit beta | Alias Symbol: CD113t-C|beta-globin | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 3043 | HGNC ID: HGNC:4827 | Ensembl Gene: ENSG00000244734 | OMIM ID: 141900 |
| Related drugs: EFAPROXIRAL, IRON DEXTRAN... [more] | |||
Expression of HBB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HBB | 3043 | 211696_x_at | 0.0820 | 0.9792 | |
| GSE20347 | HBB | 3043 | 211696_x_at | -1.0528 | 0.0027 | |
| GSE23400 | HBB | 3043 | 211696_x_at | -0.6610 | 0.0075 | |
| GSE26886 | HBB | 3043 | 211696_x_at | -2.4034 | 0.0004 | |
| GSE29001 | HBB | 3043 | 211696_x_at | -0.5470 | 0.0886 | |
| GSE38129 | HBB | 3043 | 217232_x_at | -1.5681 | 0.0008 | |
| GSE45670 | HBB | 3043 | 211696_x_at | -1.0649 | 0.2182 | |
| GSE53622 | HBB | 3043 | 89361 | -1.4368 | 0.0000 | |
| GSE53624 | HBB | 3043 | 20752 | -1.2544 | 0.0000 | |
| GSE63941 | HBB | 3043 | 1562981_at | 0.1304 | 0.3425 | |
| GSE77861 | HBB | 3043 | 211696_x_at | 0.6827 | 0.6267 | |
| GSE97050 | HBB | 3043 | A_23_P203558 | -0.9092 | 0.2905 | |
| SRP007169 | HBB | 3043 | RNAseq | 0.2522 | 0.5983 | |
| SRP064894 | HBB | 3043 | RNAseq | -2.3585 | 0.0000 | |
| SRP133303 | HBB | 3043 | RNAseq | -1.3218 | 0.0911 | |
| SRP159526 | HBB | 3043 | RNAseq | -2.6290 | 0.0244 | |
| SRP193095 | HBB | 3043 | RNAseq | 0.3934 | 0.3445 | |
| SRP219564 | HBB | 3043 | RNAseq | 0.1875 | 0.8723 | |
| TCGA | HBB | 3043 | RNAseq | -1.1923 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by HBB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HBB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HBB | 3043 | 1 | 11 | 18 | |
| GSE20123 | HBB | 3043 | 1 | 11 | 18 | |
| GSE43470 | HBB | 3043 | 1 | 8 | 34 | |
| GSE46452 | HBB | 3043 | 7 | 8 | 44 | |
| GSE47630 | HBB | 3043 | 3 | 13 | 24 | |
| GSE54993 | HBB | 3043 | 3 | 1 | 66 | |
| GSE54994 | HBB | 3043 | 2 | 12 | 39 | |
| GSE60625 | HBB | 3043 | 0 | 0 | 11 | |
| GSE74703 | HBB | 3043 | 1 | 6 | 29 | |
| GSE74704 | HBB | 3043 | 0 | 8 | 12 | |
| TCGA | HBB | 3043 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 117; Total Number of normals: 344.
Somatic mutations of HBB:
Generating mutation plots.
Highly correlated genes for HBB:
Showing top 20/56 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HBB | HBA2 | 0.894453 | 4 | 0 | 4 |
| HBB | PF4 | 0.607792 | 4 | 0 | 3 |
| HBB | TSC22D3 | 0.581439 | 5 | 0 | 3 |
| HBB | PLVAP | 0.580311 | 4 | 0 | 3 |
| HBB | ARHGEF26 | 0.578639 | 4 | 0 | 3 |
| HBB | CRELD1 | 0.569372 | 7 | 0 | 4 |
| HBB | PTK6 | 0.569088 | 3 | 0 | 3 |
| HBB | GRIN2A | 0.566488 | 5 | 0 | 4 |
| HBB | FAM107A | 0.564137 | 7 | 0 | 3 |
| HBB | ACKR1 | 0.564075 | 7 | 0 | 3 |
| HBB | HIGD1B | 0.56216 | 5 | 0 | 3 |
| HBB | TMEM71 | 0.561119 | 5 | 0 | 3 |
| HBB | ATP6V1E1 | 0.551843 | 4 | 0 | 3 |
| HBB | GJA4 | 0.550923 | 5 | 0 | 3 |
| HBB | RAP1A | 0.549789 | 6 | 0 | 3 |
| HBB | PRELP | 0.549243 | 5 | 0 | 4 |
| HBB | XPNPEP2 | 0.545305 | 4 | 0 | 3 |
| HBB | MYL6 | 0.543604 | 7 | 0 | 4 |
| HBB | ADAMTSL3 | 0.54307 | 6 | 0 | 4 |
| HBB | GAB1 | 0.541334 | 6 | 0 | 3 |
For details and further investigation, click here
