| Full name: ATPase H+ transporting V1 subunit E1 | Alias Symbol: P31|Vma4|ATP6E2 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 529 | HGNC ID: HGNC:857 | Ensembl Gene: ENSG00000131100 | OMIM ID: 108746 |
| Drug and gene relationship at DGIdb | |||
ATP6V1E1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway | |
| hsa05110 | Vibrio cholerae infection | |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
Expression of ATP6V1E1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATP6V1E1 | 529 | 208678_at | -0.1206 | 0.8114 | |
| GSE20347 | ATP6V1E1 | 529 | 208678_at | -0.3373 | 0.0192 | |
| GSE23400 | ATP6V1E1 | 529 | 208678_at | -0.2206 | 0.0000 | |
| GSE26886 | ATP6V1E1 | 529 | 208678_at | -0.5336 | 0.0027 | |
| GSE29001 | ATP6V1E1 | 529 | 208678_at | -0.4667 | 0.0125 | |
| GSE38129 | ATP6V1E1 | 529 | 208678_at | -0.2572 | 0.0562 | |
| GSE45670 | ATP6V1E1 | 529 | 208678_at | -0.1607 | 0.2107 | |
| GSE53622 | ATP6V1E1 | 529 | 108378 | -0.2188 | 0.0084 | |
| GSE53624 | ATP6V1E1 | 529 | 108378 | -0.4922 | 0.0000 | |
| GSE63941 | ATP6V1E1 | 529 | 208678_at | -0.7417 | 0.0773 | |
| GSE77861 | ATP6V1E1 | 529 | 208678_at | 0.2627 | 0.2068 | |
| GSE97050 | ATP6V1E1 | 529 | A_23_P143551 | -0.6569 | 0.0778 | |
| SRP007169 | ATP6V1E1 | 529 | RNAseq | -0.9821 | 0.0144 | |
| SRP008496 | ATP6V1E1 | 529 | RNAseq | -0.9493 | 0.0000 | |
| SRP064894 | ATP6V1E1 | 529 | RNAseq | -0.1971 | 0.2075 | |
| SRP133303 | ATP6V1E1 | 529 | RNAseq | -0.2111 | 0.1783 | |
| SRP159526 | ATP6V1E1 | 529 | RNAseq | -0.4390 | 0.1153 | |
| SRP193095 | ATP6V1E1 | 529 | RNAseq | -0.5257 | 0.0013 | |
| SRP219564 | ATP6V1E1 | 529 | RNAseq | -0.5869 | 0.0897 | |
| TCGA | ATP6V1E1 | 529 | RNAseq | -0.0021 | 0.9630 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ATP6V1E1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATP6V1E1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATP6V1E1 | 529 | 4 | 7 | 19 | |
| GSE20123 | ATP6V1E1 | 529 | 4 | 7 | 19 | |
| GSE43470 | ATP6V1E1 | 529 | 5 | 7 | 31 | |
| GSE46452 | ATP6V1E1 | 529 | 32 | 2 | 25 | |
| GSE47630 | ATP6V1E1 | 529 | 8 | 5 | 27 | |
| GSE54993 | ATP6V1E1 | 529 | 2 | 7 | 61 | |
| GSE54994 | ATP6V1E1 | 529 | 12 | 7 | 34 | |
| GSE60625 | ATP6V1E1 | 529 | 5 | 0 | 6 | |
| GSE74703 | ATP6V1E1 | 529 | 5 | 5 | 26 | |
| GSE74704 | ATP6V1E1 | 529 | 2 | 4 | 14 | |
| TCGA | ATP6V1E1 | 529 | 25 | 17 | 54 |
Total number of gains: 104; Total number of losses: 68; Total Number of normals: 316.
Somatic mutations of ATP6V1E1:
Generating mutation plots.
Highly correlated genes for ATP6V1E1:
Showing top 20/493 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATP6V1E1 | DRAM2 | 0.742907 | 3 | 0 | 3 |
| ATP6V1E1 | GPR108 | 0.729101 | 3 | 0 | 3 |
| ATP6V1E1 | TMEM106B | 0.725931 | 3 | 0 | 3 |
| ATP6V1E1 | PTPMT1 | 0.722363 | 3 | 0 | 3 |
| ATP6V1E1 | RAB12 | 0.717851 | 3 | 0 | 3 |
| ATP6V1E1 | GMPPB | 0.716159 | 3 | 0 | 3 |
| ATP6V1E1 | MRPS11 | 0.713716 | 4 | 0 | 3 |
| ATP6V1E1 | GSTM3 | 0.709203 | 3 | 0 | 3 |
| ATP6V1E1 | FBXO39 | 0.699053 | 3 | 0 | 3 |
| ATP6V1E1 | CYP4V2 | 0.698235 | 3 | 0 | 3 |
| ATP6V1E1 | THG1L | 0.691525 | 3 | 0 | 3 |
| ATP6V1E1 | SH3BGRL | 0.687457 | 4 | 0 | 3 |
| ATP6V1E1 | MTFMT | 0.686621 | 3 | 0 | 3 |
| ATP6V1E1 | UQCR10 | 0.686207 | 5 | 0 | 5 |
| ATP6V1E1 | ERLEC1 | 0.682706 | 4 | 0 | 4 |
| ATP6V1E1 | PPT2 | 0.68012 | 3 | 0 | 3 |
| ATP6V1E1 | CSDE1 | 0.679839 | 3 | 0 | 3 |
| ATP6V1E1 | IL13RA2 | 0.678811 | 3 | 0 | 3 |
| ATP6V1E1 | VPS25 | 0.674476 | 5 | 0 | 4 |
| ATP6V1E1 | RAD50 | 0.673705 | 5 | 0 | 5 |
For details and further investigation, click here
