| Full name: gap junction protein alpha 4 | Alias Symbol: CX37 | ||
| Type: protein-coding gene | Cytoband: 1p34.3 | ||
| Entrez ID: 2701 | HGNC ID: HGNC:4278 | Ensembl Gene: ENSG00000187513 | OMIM ID: 121012 |
| Drug and gene relationship at DGIdb | |||
Expression of GJA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GJA4 | 2701 | 204904_at | -0.0190 | 0.9826 | |
| GSE20347 | GJA4 | 2701 | 204904_at | -0.0095 | 0.9230 | |
| GSE23400 | GJA4 | 2701 | 204904_at | -0.0571 | 0.2338 | |
| GSE26886 | GJA4 | 2701 | 204904_at | 0.4685 | 0.0054 | |
| GSE29001 | GJA4 | 2701 | 204904_at | -0.1354 | 0.4842 | |
| GSE38129 | GJA4 | 2701 | 204904_at | -0.1538 | 0.3319 | |
| GSE45670 | GJA4 | 2701 | 204904_at | -0.4718 | 0.0128 | |
| GSE53622 | GJA4 | 2701 | 3532 | -0.1852 | 0.0476 | |
| GSE53624 | GJA4 | 2701 | 3532 | -0.0841 | 0.3328 | |
| GSE63941 | GJA4 | 2701 | 204904_at | 0.0669 | 0.7295 | |
| GSE77861 | GJA4 | 2701 | 204904_at | 0.1593 | 0.3994 | |
| GSE97050 | GJA4 | 2701 | A_23_P1083 | 0.3955 | 0.2744 | |
| SRP007169 | GJA4 | 2701 | RNAseq | 1.6763 | 0.0791 | |
| SRP064894 | GJA4 | 2701 | RNAseq | 1.2105 | 0.0079 | |
| SRP133303 | GJA4 | 2701 | RNAseq | -0.3422 | 0.2304 | |
| SRP159526 | GJA4 | 2701 | RNAseq | 0.2908 | 0.4835 | |
| SRP219564 | GJA4 | 2701 | RNAseq | 0.1281 | 0.8508 | |
| TCGA | GJA4 | 2701 | RNAseq | 0.0366 | 0.8000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GJA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GJA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GJA4 | 2701 | 2 | 5 | 23 | |
| GSE20123 | GJA4 | 2701 | 2 | 4 | 24 | |
| GSE43470 | GJA4 | 2701 | 6 | 2 | 35 | |
| GSE46452 | GJA4 | 2701 | 4 | 1 | 54 | |
| GSE47630 | GJA4 | 2701 | 8 | 3 | 29 | |
| GSE54993 | GJA4 | 2701 | 1 | 1 | 68 | |
| GSE54994 | GJA4 | 2701 | 11 | 2 | 40 | |
| GSE60625 | GJA4 | 2701 | 0 | 0 | 11 | |
| GSE74703 | GJA4 | 2701 | 5 | 1 | 30 | |
| GSE74704 | GJA4 | 2701 | 1 | 0 | 19 | |
| TCGA | GJA4 | 2701 | 13 | 18 | 65 |
Total number of gains: 53; Total number of losses: 37; Total Number of normals: 398.
Somatic mutations of GJA4:
Generating mutation plots.
Highly correlated genes for GJA4:
Showing top 20/546 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GJA4 | ELK1 | 0.77197 | 3 | 0 | 3 |
| GJA4 | HRH2 | 0.72947 | 4 | 0 | 3 |
| GJA4 | PHC2 | 0.709865 | 3 | 0 | 3 |
| GJA4 | MEIS3 | 0.700595 | 4 | 0 | 4 |
| GJA4 | SP7 | 0.698244 | 3 | 0 | 3 |
| GJA4 | SNAPC2 | 0.697757 | 4 | 0 | 3 |
| GJA4 | LY86 | 0.694811 | 3 | 0 | 3 |
| GJA4 | SPRED3 | 0.693787 | 4 | 0 | 3 |
| GJA4 | CD34 | 0.682195 | 7 | 0 | 6 |
| GJA4 | COL1A1 | 0.681291 | 3 | 0 | 3 |
| GJA4 | RAMP3 | 0.679272 | 8 | 0 | 7 |
| GJA4 | ALPL | 0.678398 | 3 | 0 | 3 |
| GJA4 | PTGIR | 0.678362 | 5 | 0 | 5 |
| GJA4 | PNMA2 | 0.676636 | 4 | 0 | 4 |
| GJA4 | SH2D5 | 0.676611 | 3 | 0 | 3 |
| GJA4 | ENPP2 | 0.674293 | 5 | 0 | 4 |
| GJA4 | ENG | 0.670145 | 10 | 0 | 9 |
| GJA4 | MTNR1B | 0.665866 | 3 | 0 | 3 |
| GJA4 | PDGFB | 0.661367 | 4 | 0 | 4 |
| GJA4 | ARVCF | 0.660111 | 5 | 0 | 4 |
For details and further investigation, click here
