| Full name: histone deacetylase 5 | Alias Symbol: KIAA0600|NY-CO-9|FLJ90614 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 10014 | HGNC ID: HGNC:14068 | Ensembl Gene: ENSG00000108840 | OMIM ID: 605315 |
| Drug and gene relationship at DGIdb | |||
Expression of HDAC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HDAC5 | 10014 | 202455_at | -0.8520 | 0.0559 | |
| GSE20347 | HDAC5 | 10014 | 202455_at | -0.9013 | 0.0000 | |
| GSE23400 | HDAC5 | 10014 | 202455_at | -0.5759 | 0.0000 | |
| GSE26886 | HDAC5 | 10014 | 202455_at | -1.2898 | 0.0000 | |
| GSE29001 | HDAC5 | 10014 | 202455_at | -0.9031 | 0.0305 | |
| GSE38129 | HDAC5 | 10014 | 202455_at | -0.8995 | 0.0000 | |
| GSE45670 | HDAC5 | 10014 | 202455_at | -0.6928 | 0.0001 | |
| GSE53622 | HDAC5 | 10014 | 63270 | -1.0080 | 0.0000 | |
| GSE53624 | HDAC5 | 10014 | 63270 | -0.9114 | 0.0000 | |
| GSE63941 | HDAC5 | 10014 | 202455_at | -0.2732 | 0.4778 | |
| GSE77861 | HDAC5 | 10014 | 202455_at | -0.7396 | 0.0359 | |
| GSE97050 | HDAC5 | 10014 | A_24_P125283 | -0.2413 | 0.4522 | |
| SRP007169 | HDAC5 | 10014 | RNAseq | -2.0269 | 0.0000 | |
| SRP008496 | HDAC5 | 10014 | RNAseq | -1.8485 | 0.0000 | |
| SRP064894 | HDAC5 | 10014 | RNAseq | -0.4412 | 0.0345 | |
| SRP133303 | HDAC5 | 10014 | RNAseq | -1.0522 | 0.0000 | |
| SRP159526 | HDAC5 | 10014 | RNAseq | -0.7104 | 0.0028 | |
| SRP193095 | HDAC5 | 10014 | RNAseq | -0.9453 | 0.0000 | |
| SRP219564 | HDAC5 | 10014 | RNAseq | -0.7338 | 0.0574 | |
| TCGA | HDAC5 | 10014 | RNAseq | -0.1702 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by HDAC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HDAC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HDAC5 | 10014 | 5 | 2 | 23 | |
| GSE20123 | HDAC5 | 10014 | 5 | 2 | 23 | |
| GSE43470 | HDAC5 | 10014 | 1 | 2 | 40 | |
| GSE46452 | HDAC5 | 10014 | 32 | 0 | 27 | |
| GSE47630 | HDAC5 | 10014 | 9 | 0 | 31 | |
| GSE54993 | HDAC5 | 10014 | 3 | 4 | 63 | |
| GSE54994 | HDAC5 | 10014 | 8 | 5 | 40 | |
| GSE60625 | HDAC5 | 10014 | 4 | 0 | 7 | |
| GSE74703 | HDAC5 | 10014 | 1 | 1 | 34 | |
| GSE74704 | HDAC5 | 10014 | 3 | 1 | 16 | |
| TCGA | HDAC5 | 10014 | 23 | 7 | 66 |
Total number of gains: 94; Total number of losses: 24; Total Number of normals: 370.
Somatic mutations of HDAC5:
Generating mutation plots.
Highly correlated genes for HDAC5:
Showing top 20/1551 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HDAC5 | SNORA68 | 0.788002 | 4 | 0 | 4 |
| HDAC5 | MAGEC1 | 0.780434 | 3 | 0 | 3 |
| HDAC5 | SMDT1 | 0.767027 | 4 | 0 | 4 |
| HDAC5 | RMND5B | 0.7588 | 11 | 0 | 11 |
| HDAC5 | CGNL1 | 0.746649 | 7 | 0 | 7 |
| HDAC5 | ZNF548 | 0.744196 | 4 | 0 | 4 |
| HDAC5 | WDFY1 | 0.736468 | 3 | 0 | 3 |
| HDAC5 | ZNF416 | 0.734405 | 4 | 0 | 4 |
| HDAC5 | RBM20 | 0.729971 | 5 | 0 | 5 |
| HDAC5 | ACADVL | 0.727884 | 11 | 0 | 10 |
| HDAC5 | CTTNBP2 | 0.721232 | 6 | 0 | 6 |
| HDAC5 | SORT1 | 0.710657 | 11 | 0 | 10 |
| HDAC5 | WDR61 | 0.708539 | 3 | 0 | 3 |
| HDAC5 | ABR | 0.708453 | 11 | 0 | 11 |
| HDAC5 | ECHDC2 | 0.70806 | 11 | 0 | 11 |
| HDAC5 | USP54 | 0.706797 | 7 | 0 | 7 |
| HDAC5 | SPNS2 | 0.706008 | 4 | 0 | 4 |
| HDAC5 | CALCOCO2 | 0.703389 | 10 | 0 | 9 |
| HDAC5 | ARHGAP10 | 0.703022 | 11 | 0 | 11 |
| HDAC5 | SFTA2 | 0.700952 | 4 | 0 | 4 |
For details and further investigation, click here
