| Full name: ABR activator of RhoGEF and GTPase | Alias Symbol: MDB | ||
| Type: protein-coding gene | Cytoband: 17p13.3 | ||
| Entrez ID: 29 | HGNC ID: HGNC:81 | Ensembl Gene: ENSG00000159842 | OMIM ID: 600365 |
| Drug and gene relationship at DGIdb | |||
Expression of ABR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABR | 29 | 212895_s_at | -0.6506 | 0.0900 | |
| GSE20347 | ABR | 29 | 212895_s_at | -1.1079 | 0.0000 | |
| GSE23400 | ABR | 29 | 212895_s_at | -0.8531 | 0.0000 | |
| GSE26886 | ABR | 29 | 212895_s_at | -0.7840 | 0.0014 | |
| GSE29001 | ABR | 29 | 212895_s_at | -1.0377 | 0.0000 | |
| GSE38129 | ABR | 29 | 212895_s_at | -0.9926 | 0.0000 | |
| GSE45670 | ABR | 29 | 212895_s_at | -0.3811 | 0.0590 | |
| GSE53622 | ABR | 29 | 18755 | -1.2076 | 0.0000 | |
| GSE53624 | ABR | 29 | 60224 | -1.1693 | 0.0000 | |
| GSE63941 | ABR | 29 | 212895_s_at | -0.9595 | 0.0408 | |
| GSE77861 | ABR | 29 | 212895_s_at | -0.7162 | 0.0196 | |
| GSE97050 | ABR | 29 | A_33_P3372297 | -0.7812 | 0.0781 | |
| SRP007169 | ABR | 29 | RNAseq | -0.5192 | 0.2272 | |
| SRP008496 | ABR | 29 | RNAseq | -0.5745 | 0.0629 | |
| SRP064894 | ABR | 29 | RNAseq | -0.8866 | 0.0000 | |
| SRP133303 | ABR | 29 | RNAseq | -1.1534 | 0.0000 | |
| SRP159526 | ABR | 29 | RNAseq | -1.4991 | 0.0000 | |
| SRP193095 | ABR | 29 | RNAseq | -0.7189 | 0.0000 | |
| SRP219564 | ABR | 29 | RNAseq | -0.5591 | 0.0448 | |
| TCGA | ABR | 29 | RNAseq | -0.1486 | 0.0039 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by ABR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABR | 29 | 5 | 2 | 23 | |
| GSE20123 | ABR | 29 | 5 | 3 | 22 | |
| GSE43470 | ABR | 29 | 3 | 6 | 34 | |
| GSE46452 | ABR | 29 | 34 | 1 | 24 | |
| GSE47630 | ABR | 29 | 8 | 1 | 31 | |
| GSE54993 | ABR | 29 | 9 | 3 | 58 | |
| GSE54994 | ABR | 29 | 7 | 9 | 37 | |
| GSE60625 | ABR | 29 | 4 | 0 | 7 | |
| GSE74703 | ABR | 29 | 2 | 3 | 31 | |
| GSE74704 | ABR | 29 | 3 | 1 | 16 | |
| TCGA | ABR | 29 | 19 | 21 | 56 |
Total number of gains: 99; Total number of losses: 50; Total Number of normals: 339.
Somatic mutations of ABR:
Generating mutation plots.
Highly correlated genes for ABR:
Showing top 20/1643 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABR | ACOX3 | 0.801274 | 11 | 0 | 11 |
| ABR | SORT1 | 0.781461 | 11 | 0 | 11 |
| ABR | TPCN1 | 0.781194 | 11 | 0 | 11 |
| ABR | SCNN1B | 0.779821 | 10 | 0 | 10 |
| ABR | STK39 | 0.776997 | 11 | 0 | 11 |
| ABR | CLEC3B | 0.772168 | 3 | 0 | 3 |
| ABR | CYP2J2 | 0.771394 | 10 | 0 | 10 |
| ABR | UBL3 | 0.766733 | 10 | 0 | 10 |
| ABR | TRIP10 | 0.764443 | 11 | 0 | 11 |
| ABR | GPD1L | 0.760296 | 11 | 0 | 11 |
| ABR | CGNL1 | 0.752572 | 7 | 0 | 7 |
| ABR | RRAGD | 0.752553 | 11 | 0 | 11 |
| ABR | ARHGEF10L | 0.751799 | 12 | 0 | 10 |
| ABR | CYP21A2 | 0.751131 | 3 | 0 | 3 |
| ABR | CAB39L | 0.750538 | 11 | 0 | 11 |
| ABR | KANK1 | 0.75008 | 11 | 0 | 11 |
| ABR | ANXA11 | 0.749705 | 10 | 0 | 10 |
| ABR | CXCR2 | 0.748997 | 11 | 0 | 10 |
| ABR | GYS2 | 0.748309 | 10 | 0 | 10 |
| ABR | NDST1 | 0.748306 | 9 | 0 | 9 |
For details and further investigation, click here
