| Full name: phosphoribosyl pyrophosphate synthetase 1 like 1 | Alias Symbol: PRPS3 | ||
| Type: protein-coding gene | Cytoband: 7p21.1 | ||
| Entrez ID: 221823 | HGNC ID: HGNC:9463 | Ensembl Gene: ENSG00000229937 | OMIM ID: 611566 |
| Drug and gene relationship at DGIdb | |||
Expression of PRPS1L1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRPS1L1 | 221823 | 215486_at | 0.0067 | 0.9816 | |
| GSE20347 | PRPS1L1 | 221823 | 215486_at | 0.0309 | 0.7119 | |
| GSE23400 | PRPS1L1 | 221823 | 215486_at | -0.0178 | 0.5786 | |
| GSE26886 | PRPS1L1 | 221823 | 215486_at | 0.0606 | 0.5053 | |
| GSE29001 | PRPS1L1 | 221823 | 215486_at | -0.1605 | 0.2210 | |
| GSE38129 | PRPS1L1 | 221823 | 215486_at | 0.0313 | 0.6646 | |
| GSE45670 | PRPS1L1 | 221823 | 215486_at | 0.0076 | 0.9436 | |
| GSE53622 | PRPS1L1 | 221823 | 48258 | 0.7391 | 0.0000 | |
| GSE53624 | PRPS1L1 | 221823 | 48258 | 0.9084 | 0.0000 | |
| GSE63941 | PRPS1L1 | 221823 | 215486_at | 0.2200 | 0.1478 | |
| GSE77861 | PRPS1L1 | 221823 | 215486_at | -0.0659 | 0.5557 | |
| GSE97050 | PRPS1L1 | 221823 | A_32_P192823 | 0.2139 | 0.5137 | |
| TCGA | PRPS1L1 | 221823 | RNAseq | 1.4196 | 0.4893 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PRPS1L1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRPS1L1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRPS1L1 | 221823 | 15 | 2 | 13 | |
| GSE20123 | PRPS1L1 | 221823 | 15 | 2 | 13 | |
| GSE43470 | PRPS1L1 | 221823 | 5 | 0 | 38 | |
| GSE46452 | PRPS1L1 | 221823 | 11 | 1 | 47 | |
| GSE47630 | PRPS1L1 | 221823 | 9 | 1 | 30 | |
| GSE54993 | PRPS1L1 | 221823 | 0 | 6 | 64 | |
| GSE54994 | PRPS1L1 | 221823 | 21 | 1 | 31 | |
| GSE60625 | PRPS1L1 | 221823 | 0 | 0 | 11 | |
| GSE74703 | PRPS1L1 | 221823 | 5 | 0 | 31 | |
| GSE74704 | PRPS1L1 | 221823 | 9 | 2 | 9 | |
| TCGA | PRPS1L1 | 221823 | 56 | 5 | 35 |
Total number of gains: 146; Total number of losses: 20; Total Number of normals: 322.
Somatic mutations of PRPS1L1:
Generating mutation plots.
Highly correlated genes for PRPS1L1:
Showing top 20/766 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRPS1L1 | KIAA0319L | 0.801479 | 3 | 0 | 3 |
| PRPS1L1 | CA8 | 0.797852 | 3 | 0 | 3 |
| PRPS1L1 | SLC35E3 | 0.782356 | 3 | 0 | 3 |
| PRPS1L1 | RECK | 0.762129 | 4 | 0 | 4 |
| PRPS1L1 | NKAP | 0.751248 | 3 | 0 | 3 |
| PRPS1L1 | NPFF | 0.748476 | 4 | 0 | 4 |
| PRPS1L1 | ATG10 | 0.742362 | 5 | 0 | 5 |
| PRPS1L1 | BOLA3 | 0.733452 | 3 | 0 | 3 |
| PRPS1L1 | SAG | 0.72686 | 6 | 0 | 6 |
| PRPS1L1 | HECTD3 | 0.725875 | 3 | 0 | 3 |
| PRPS1L1 | HPCAL1 | 0.722948 | 3 | 0 | 3 |
| PRPS1L1 | CLMN | 0.722137 | 3 | 0 | 3 |
| PRPS1L1 | KRTAP5-8 | 0.721591 | 6 | 0 | 6 |
| PRPS1L1 | EDDM3A | 0.721076 | 3 | 0 | 3 |
| PRPS1L1 | RILP | 0.719595 | 3 | 0 | 3 |
| PRPS1L1 | EVI5L | 0.717665 | 3 | 0 | 3 |
| PRPS1L1 | TAS2R4 | 0.716387 | 5 | 0 | 5 |
| PRPS1L1 | SARDH | 0.713324 | 4 | 0 | 4 |
| PRPS1L1 | MRPL47 | 0.712916 | 3 | 0 | 3 |
| PRPS1L1 | CNTF | 0.712481 | 4 | 0 | 3 |
For details and further investigation, click here
