| Full name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | Alias Symbol: FLJ20637 | ||
| Type: protein-coding gene | Cytoband: 4q22.1 | ||
| Entrez ID: 55008 | HGNC ID: HGNC:26072 | Ensembl Gene: ENSG00000138642 | OMIM ID: 609249 |
| Drug and gene relationship at DGIdb | |||
Expression of HERC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HERC6 | 55008 | 219352_at | -0.9106 | 0.4881 | |
| GSE20347 | HERC6 | 55008 | 219352_at | -1.3871 | 0.0004 | |
| GSE23400 | HERC6 | 55008 | 219352_at | -0.8101 | 0.0000 | |
| GSE26886 | HERC6 | 55008 | 219352_at | -1.6884 | 0.0001 | |
| GSE29001 | HERC6 | 55008 | 219352_at | -0.6074 | 0.2730 | |
| GSE38129 | HERC6 | 55008 | 219352_at | -0.9874 | 0.0065 | |
| GSE45670 | HERC6 | 55008 | 219352_at | 0.2789 | 0.6142 | |
| GSE53622 | HERC6 | 55008 | 104013 | -0.8626 | 0.0000 | |
| GSE53624 | HERC6 | 55008 | 155794 | -0.9075 | 0.0000 | |
| GSE63941 | HERC6 | 55008 | 219352_at | -0.3445 | 0.7647 | |
| GSE77861 | HERC6 | 55008 | 219352_at | -1.6498 | 0.0192 | |
| GSE97050 | HERC6 | 55008 | A_33_P3315779 | -0.2640 | 0.7835 | |
| SRP007169 | HERC6 | 55008 | RNAseq | -1.5658 | 0.0000 | |
| SRP008496 | HERC6 | 55008 | RNAseq | -1.9077 | 0.0000 | |
| SRP064894 | HERC6 | 55008 | RNAseq | -0.3281 | 0.3393 | |
| SRP133303 | HERC6 | 55008 | RNAseq | -1.0755 | 0.0014 | |
| SRP159526 | HERC6 | 55008 | RNAseq | -2.5434 | 0.0000 | |
| SRP193095 | HERC6 | 55008 | RNAseq | -0.6584 | 0.0052 | |
| SRP219564 | HERC6 | 55008 | RNAseq | -0.9284 | 0.2471 | |
| TCGA | HERC6 | 55008 | RNAseq | 0.1508 | 0.2444 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by HERC6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HERC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HERC6 | 55008 | 2 | 12 | 16 | |
| GSE20123 | HERC6 | 55008 | 2 | 12 | 16 | |
| GSE43470 | HERC6 | 55008 | 0 | 13 | 30 | |
| GSE46452 | HERC6 | 55008 | 1 | 36 | 22 | |
| GSE47630 | HERC6 | 55008 | 0 | 20 | 20 | |
| GSE54993 | HERC6 | 55008 | 8 | 0 | 62 | |
| GSE54994 | HERC6 | 55008 | 1 | 10 | 42 | |
| GSE60625 | HERC6 | 55008 | 0 | 0 | 11 | |
| GSE74703 | HERC6 | 55008 | 0 | 11 | 25 | |
| GSE74704 | HERC6 | 55008 | 2 | 7 | 11 | |
| TCGA | HERC6 | 55008 | 12 | 37 | 47 |
Total number of gains: 28; Total number of losses: 158; Total Number of normals: 302.
Somatic mutations of HERC6:
Generating mutation plots.
Highly correlated genes for HERC6:
Showing top 20/1163 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HERC6 | AKAP17A | 0.760408 | 3 | 0 | 3 |
| HERC6 | KIF21A | 0.735781 | 3 | 0 | 3 |
| HERC6 | SCML4 | 0.723597 | 3 | 0 | 3 |
| HERC6 | RBM20 | 0.720476 | 4 | 0 | 4 |
| HERC6 | LYRM7 | 0.716006 | 3 | 0 | 3 |
| HERC6 | IL18 | 0.714283 | 7 | 0 | 7 |
| HERC6 | ZNF208 | 0.713211 | 3 | 0 | 3 |
| HERC6 | VPS25 | 0.708896 | 5 | 0 | 4 |
| HERC6 | TOM1L1 | 0.708396 | 3 | 0 | 3 |
| HERC6 | SLC10A7 | 0.704625 | 3 | 0 | 3 |
| HERC6 | ANKRD37 | 0.703742 | 3 | 0 | 3 |
| HERC6 | TOM1 | 0.69697 | 8 | 0 | 8 |
| HERC6 | OAS1 | 0.695378 | 13 | 0 | 12 |
| HERC6 | SAMD9 | 0.69225 | 12 | 0 | 11 |
| HERC6 | CNFN | 0.686121 | 4 | 0 | 3 |
| HERC6 | TMEM220 | 0.683935 | 4 | 0 | 3 |
| HERC6 | MGST2 | 0.683676 | 8 | 0 | 7 |
| HERC6 | BRWD1 | 0.678663 | 3 | 0 | 3 |
| HERC6 | PET100 | 0.678371 | 3 | 0 | 3 |
| HERC6 | MFSD5 | 0.678248 | 9 | 0 | 8 |
For details and further investigation, click here
