| Full name: TEA domain transcription factor 1 | Alias Symbol: TEF-1 | ||
| Type: protein-coding gene | Cytoband: 11p15.3 | ||
| Entrez ID: 7003 | HGNC ID: HGNC:11714 | Ensembl Gene: ENSG00000187079 | OMIM ID: 189967 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
TEAD1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway |
Expression of TEAD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TEAD1 | 7003 | 224955_at | -0.7604 | 0.1328 | |
| GSE20347 | TEAD1 | 7003 | 214600_at | -0.6506 | 0.0001 | |
| GSE23400 | TEAD1 | 7003 | 214600_at | -0.3001 | 0.0000 | |
| GSE26886 | TEAD1 | 7003 | 224955_at | -1.6563 | 0.0000 | |
| GSE29001 | TEAD1 | 7003 | 214600_at | -1.0932 | 0.0160 | |
| GSE38129 | TEAD1 | 7003 | 214600_at | -0.7068 | 0.0000 | |
| GSE45670 | TEAD1 | 7003 | 224955_at | -0.7620 | 0.0001 | |
| GSE53622 | TEAD1 | 7003 | 100371 | -0.7372 | 0.0000 | |
| GSE53624 | TEAD1 | 7003 | 100371 | -0.7600 | 0.0000 | |
| GSE63941 | TEAD1 | 7003 | 224955_at | -1.9414 | 0.0003 | |
| GSE77861 | TEAD1 | 7003 | 224955_at | -0.3125 | 0.4296 | |
| GSE97050 | TEAD1 | 7003 | A_23_P362893 | -0.7008 | 0.0970 | |
| SRP007169 | TEAD1 | 7003 | RNAseq | -1.0781 | 0.0122 | |
| SRP008496 | TEAD1 | 7003 | RNAseq | -0.9554 | 0.0004 | |
| SRP064894 | TEAD1 | 7003 | RNAseq | -1.3394 | 0.0000 | |
| SRP133303 | TEAD1 | 7003 | RNAseq | -0.4048 | 0.0110 | |
| SRP159526 | TEAD1 | 7003 | RNAseq | -1.3620 | 0.0000 | |
| SRP193095 | TEAD1 | 7003 | RNAseq | -0.8630 | 0.0000 | |
| SRP219564 | TEAD1 | 7003 | RNAseq | -1.0727 | 0.0130 | |
| TCGA | TEAD1 | 7003 | RNAseq | -0.1775 | 0.0020 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by TEAD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TEAD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TEAD1 | 7003 | 0 | 9 | 21 | |
| GSE20123 | TEAD1 | 7003 | 0 | 9 | 21 | |
| GSE43470 | TEAD1 | 7003 | 1 | 5 | 37 | |
| GSE46452 | TEAD1 | 7003 | 7 | 5 | 47 | |
| GSE47630 | TEAD1 | 7003 | 3 | 11 | 26 | |
| GSE54993 | TEAD1 | 7003 | 3 | 1 | 66 | |
| GSE54994 | TEAD1 | 7003 | 4 | 12 | 37 | |
| GSE60625 | TEAD1 | 7003 | 0 | 0 | 11 | |
| GSE74703 | TEAD1 | 7003 | 1 | 3 | 32 | |
| GSE74704 | TEAD1 | 7003 | 0 | 7 | 13 | |
| TCGA | TEAD1 | 7003 | 13 | 32 | 51 |
Total number of gains: 32; Total number of losses: 94; Total Number of normals: 362.
Somatic mutations of TEAD1:
Generating mutation plots.
Highly correlated genes for TEAD1:
Showing top 20/1351 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TEAD1 | SYNC | 0.768985 | 3 | 0 | 3 |
| TEAD1 | SCARB2 | 0.73594 | 3 | 0 | 3 |
| TEAD1 | CYP4V2 | 0.729285 | 3 | 0 | 3 |
| TEAD1 | SECISBP2L | 0.726887 | 12 | 0 | 12 |
| TEAD1 | FAM98B | 0.725187 | 3 | 0 | 3 |
| TEAD1 | ITCH | 0.721853 | 8 | 0 | 8 |
| TEAD1 | SENP8 | 0.716263 | 3 | 0 | 3 |
| TEAD1 | VDAC3 | 0.709566 | 3 | 0 | 3 |
| TEAD1 | BNC2 | 0.708084 | 6 | 0 | 6 |
| TEAD1 | COG5 | 0.705882 | 4 | 0 | 4 |
| TEAD1 | FLNC | 0.70372 | 6 | 0 | 5 |
| TEAD1 | FAM219B | 0.700348 | 4 | 0 | 4 |
| TEAD1 | HEXIM1 | 0.696694 | 3 | 0 | 3 |
| TEAD1 | PHACTR2 | 0.696233 | 11 | 0 | 10 |
| TEAD1 | SH3D19 | 0.695406 | 8 | 0 | 8 |
| TEAD1 | UBXN10 | 0.694374 | 4 | 0 | 4 |
| TEAD1 | SGIP1 | 0.693029 | 3 | 0 | 3 |
| TEAD1 | SYNM | 0.692146 | 5 | 0 | 5 |
| TEAD1 | SLMAP | 0.691752 | 8 | 0 | 7 |
| TEAD1 | LRRFIP2 | 0.691048 | 10 | 0 | 9 |
For details and further investigation, click here
