UPK2

 

Full name: uroplakin 2 Alias Symbol: UP2|UPII|MGC138598
Type: protein-coding gene Cytoband: 11q23
Entrez ID: 7379 HGNC ID: HGNC:12579 Ensembl Gene: ENSG00000110375 OMIM ID: 611558
Drug and gene relationship at DGIdb

 

Expression of UPK2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 UPK2 7379 207862_at -0.2500 0.3965
GSE20347 UPK2 7379 207862_at -0.1624 0.0806
GSE23400 UPK2 7379 207862_at -0.2576 0.0000
GSE26886 UPK2 7379 207862_at -0.3211 0.0072
GSE29001 UPK2 7379 207862_at -0.4289 0.0057
GSE38129 UPK2 7379 207862_at -0.2623 0.0079
GSE45670 UPK2 7379 207862_at -0.0783 0.4824
GSE53622 UPK2 7379 108095 -1.4918 0.0000
GSE53624 UPK2 7379 108095 -1.3780 0.0000
GSE63941 UPK2 7379 207862_at 0.4084 0.1630
GSE77861 UPK2 7379 207862_at -0.3118 0.0314
SRP064894 UPK2 7379 RNAseq -3.3531 0.0000
SRP159526 UPK2 7379 RNAseq -4.2693 0.0000
TCGA UPK2 7379 RNAseq 0.9306 0.0611

Upregulated datasets: 0; Downregulated datasets: 4.  

 

Survival by UPK2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of UPK2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 UPK2 7379 2 11 17
GSE20123 UPK2 7379 2 11 17
GSE43470 UPK2 7379 2 8 33
GSE46452 UPK2 7379 3 26 30
GSE47630 UPK2 7379 2 19 19
GSE54993 UPK2 7379 10 0 60
GSE54994 UPK2 7379 5 19 29
GSE60625 UPK2 7379 0 3 8
GSE74703 UPK2 7379 1 5 30
GSE74704 UPK2 7379 1 7 12
TCGA UPK2 7379 4 51 41

Total number of gains: 32; Total number of losses: 160; Total Number of normals: 296.  

 

Somatic mutations of UPK2:

 

Generating mutation plots.

 

Highly correlated genes for UPK2:

 

Showing top 20/1387 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
UPK2LINC003200.77734404
UPK2SLC22A130.738587404
UPK2CEACAM30.72443706
UPK2SPATA190.715431505
UPK2SLC52A30.700697303
UPK2BTNL80.699449605
UPK2ATRNL10.698235504
UPK2G6PC20.689284505
UPK2KMT2D0.688003403
UPK2PAX80.685386606
UPK2UMOD0.683828504
UPK2MOV10L10.682325303
UPK2CYP2C190.68015605
UPK2CYP2A60.680101605
UPK2KLF10.680033404
UPK2TEAD30.677555403
UPK2NPAP10.677488505
UPK2MED310.677143404
UPK2SPINT30.677055505
UPK2LALBA0.671739505

For details and further investigation, click here