| Full name: adrenoceptor beta 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q25.3 | ||
| Entrez ID: 153 | HGNC ID: HGNC:285 | Ensembl Gene: ENSG00000043591 | OMIM ID: 109630 |
| Drug and gene relationship at DGIdb | |||
ADRB1 involved pathways:
Expression of ADRB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADRB1 | 153 | 229309_at | 0.1804 | 0.9545 | |
| GSE20347 | ADRB1 | 153 | 208214_at | -0.0292 | 0.6621 | |
| GSE23400 | ADRB1 | 153 | 208214_at | -0.0644 | 0.0013 | |
| GSE26886 | ADRB1 | 153 | 229277_at | -0.0126 | 0.9053 | |
| GSE29001 | ADRB1 | 153 | 208214_at | -0.0163 | 0.8880 | |
| GSE38129 | ADRB1 | 153 | 208214_at | -0.0989 | 0.0590 | |
| GSE45670 | ADRB1 | 153 | 229309_at | -2.1456 | 0.0001 | |
| GSE53622 | ADRB1 | 153 | 60201 | -1.6937 | 0.0000 | |
| GSE53624 | ADRB1 | 153 | 60201 | -1.3841 | 0.0000 | |
| GSE63941 | ADRB1 | 153 | 229309_at | 1.8546 | 0.0926 | |
| GSE77861 | ADRB1 | 153 | 208214_at | -0.0505 | 0.6315 | |
| GSE97050 | ADRB1 | 153 | A_33_P3310189 | -0.5782 | 0.1894 | |
| SRP064894 | ADRB1 | 153 | RNAseq | -1.3100 | 0.0022 | |
| SRP133303 | ADRB1 | 153 | RNAseq | -0.1120 | 0.6349 | |
| SRP159526 | ADRB1 | 153 | RNAseq | -0.3848 | 0.5447 | |
| SRP219564 | ADRB1 | 153 | RNAseq | -0.9058 | 0.2972 | |
| TCGA | ADRB1 | 153 | RNAseq | -0.9654 | 0.0049 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ADRB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADRB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADRB1 | 153 | 2 | 8 | 20 | |
| GSE20123 | ADRB1 | 153 | 2 | 7 | 21 | |
| GSE43470 | ADRB1 | 153 | 0 | 9 | 34 | |
| GSE46452 | ADRB1 | 153 | 0 | 11 | 48 | |
| GSE47630 | ADRB1 | 153 | 2 | 14 | 24 | |
| GSE54993 | ADRB1 | 153 | 8 | 0 | 62 | |
| GSE54994 | ADRB1 | 153 | 1 | 10 | 42 | |
| GSE60625 | ADRB1 | 153 | 0 | 0 | 11 | |
| GSE74703 | ADRB1 | 153 | 0 | 6 | 30 | |
| GSE74704 | ADRB1 | 153 | 1 | 3 | 16 | |
| TCGA | ADRB1 | 153 | 4 | 28 | 64 |
Total number of gains: 20; Total number of losses: 96; Total Number of normals: 372.
Somatic mutations of ADRB1:
Generating mutation plots.
Highly correlated genes for ADRB1:
Showing top 20/511 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADRB1 | INSRR | 0.778786 | 3 | 0 | 3 |
| ADRB1 | FOXP4 | 0.772956 | 3 | 0 | 3 |
| ADRB1 | ADCK1 | 0.771076 | 3 | 0 | 3 |
| ADRB1 | CLEC3B | 0.760074 | 3 | 0 | 3 |
| ADRB1 | CYP21A2 | 0.747468 | 3 | 0 | 3 |
| ADRB1 | PI16 | 0.736116 | 4 | 0 | 4 |
| ADRB1 | NDUFB11 | 0.709711 | 3 | 0 | 3 |
| ADRB1 | NUDT7 | 0.708391 | 3 | 0 | 3 |
| ADRB1 | EIF4E3 | 0.704998 | 4 | 0 | 4 |
| ADRB1 | ADAM30 | 0.702979 | 3 | 0 | 3 |
| ADRB1 | VPS13D | 0.702877 | 3 | 0 | 3 |
| ADRB1 | ZNF473 | 0.694966 | 4 | 0 | 4 |
| ADRB1 | ITGA8 | 0.692069 | 5 | 0 | 5 |
| ADRB1 | MYL3 | 0.691142 | 4 | 0 | 3 |
| ADRB1 | PTCHD1 | 0.680979 | 4 | 0 | 4 |
| ADRB1 | TNFSF12 | 0.679992 | 3 | 0 | 3 |
| ADRB1 | HINT3 | 0.677696 | 3 | 0 | 3 |
| ADRB1 | CGNL1 | 0.676714 | 3 | 0 | 3 |
| ADRB1 | RBFOX3 | 0.6751 | 3 | 0 | 3 |
| ADRB1 | ZNF740 | 0.673398 | 3 | 0 | 3 |
For details and further investigation, click here
