HINT1

 

Full name: histidine triad nucleotide binding protein 1 Alias Symbol: PKCI-1
Type: protein-coding gene Cytoband: 5q23.3
Entrez ID: 3094 HGNC ID: HGNC:4912 Ensembl Gene: ENSG00000169567 OMIM ID: 601314
Drug and gene relationship at DGIdb

 

Expression of HINT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HINT1 3094 1555961_a_at -0.0039 0.9914
GSE20347 HINT1 3094 200093_s_at 0.0150 0.9418
GSE23400 HINT1 3094 207721_x_at 0.1513 0.0422
GSE26886 HINT1 3094 1555961_a_at 0.5215 0.0003
GSE29001 HINT1 3094 208826_x_at -0.1564 0.6358
GSE38129 HINT1 3094 200093_s_at 0.1405 0.3152
GSE45670 HINT1 3094 1555961_a_at 0.0811 0.4947
GSE53622 HINT1 3094 155156 -0.2279 0.0000
GSE53624 HINT1 3094 155156 0.1827 0.0012
GSE63941 HINT1 3094 208826_x_at -0.1339 0.6129
GSE77861 HINT1 3094 1555961_a_at 0.0038 0.9878
GSE97050 HINT1 3094 A_32_P47554 -0.1550 0.4801
SRP007169 HINT1 3094 RNAseq -1.1104 0.0012
SRP008496 HINT1 3094 RNAseq -1.0040 0.0000
SRP064894 HINT1 3094 RNAseq -0.1361 0.5786
SRP133303 HINT1 3094 RNAseq 0.0302 0.8157
SRP159526 HINT1 3094 RNAseq 0.0022 0.9957
SRP193095 HINT1 3094 RNAseq -0.6284 0.0001
SRP219564 HINT1 3094 RNAseq -0.4369 0.0911
TCGA HINT1 3094 RNAseq 0.0696 0.1430

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by HINT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HINT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HINT1 3094 1 12 17
GSE20123 HINT1 3094 1 12 17
GSE43470 HINT1 3094 2 8 33
GSE46452 HINT1 3094 0 27 32
GSE47630 HINT1 3094 0 21 19
GSE54993 HINT1 3094 9 1 60
GSE54994 HINT1 3094 2 14 37
GSE60625 HINT1 3094 0 0 11
GSE74703 HINT1 3094 2 6 28
GSE74704 HINT1 3094 1 6 13
TCGA HINT1 3094 3 39 54

Total number of gains: 21; Total number of losses: 146; Total Number of normals: 321.  

 

Somatic mutations of HINT1:

 

Generating mutation plots.

 

Highly correlated genes for HINT1:

 

Showing top 20/361 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HINT1COMMD60.80515303
HINT1PARVB0.779276303
HINT1CHST150.770053303
HINT1ZNF6270.768703303
HINT1COPZ20.739666303
HINT1ZC3H12C0.7343303
HINT1RGL10.72796303
HINT1NFATC10.711791303
HINT1SCRN10.710573303
HINT1POC50.696961404
HINT1FSTL10.692563303
HINT1INPP4A0.691946303
HINT1POLR3C0.690484404
HINT1SYPL10.685995404
HINT1SNX50.681808303
HINT1RPL410.680205605
HINT1ZNF3190.678591303
HINT1ATP8B20.67746303
HINT1SRP140.67304403
HINT1VPS290.672911403

For details and further investigation, click here