| Full name: signal recognition particle 14 | Alias Symbol: ALURBP|MGC14326 | ||
| Type: protein-coding gene | Cytoband: 15q22 | ||
| Entrez ID: 6727 | HGNC ID: HGNC:11299 | Ensembl Gene: ENSG00000140319 | OMIM ID: 600708 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SRP14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRP14 | 6727 | 200007_at | -0.3039 | 0.1603 | |
| GSE20347 | SRP14 | 6727 | 200007_at | -0.1226 | 0.2702 | |
| GSE23400 | SRP14 | 6727 | 200007_at | -0.2190 | 0.0000 | |
| GSE26886 | SRP14 | 6727 | 200007_at | 0.1602 | 0.3042 | |
| GSE29001 | SRP14 | 6727 | 200007_at | -0.2912 | 0.1713 | |
| GSE38129 | SRP14 | 6727 | 200007_at | -0.2048 | 0.0118 | |
| GSE45670 | SRP14 | 6727 | 200007_at | -0.3009 | 0.0007 | |
| GSE53622 | SRP14 | 6727 | 57330 | -0.2987 | 0.0000 | |
| GSE53624 | SRP14 | 6727 | 57330 | -0.1547 | 0.0002 | |
| GSE63941 | SRP14 | 6727 | 200007_at | -0.3237 | 0.1821 | |
| GSE77861 | SRP14 | 6727 | 200007_at | -0.3584 | 0.0594 | |
| GSE97050 | SRP14 | 6727 | A_23_P14876 | -0.4732 | 0.1108 | |
| SRP007169 | SRP14 | 6727 | RNAseq | -0.3502 | 0.4238 | |
| SRP008496 | SRP14 | 6727 | RNAseq | -0.2993 | 0.2995 | |
| SRP064894 | SRP14 | 6727 | RNAseq | -0.3496 | 0.0629 | |
| SRP133303 | SRP14 | 6727 | RNAseq | -0.2014 | 0.2937 | |
| SRP159526 | SRP14 | 6727 | RNAseq | -0.1770 | 0.3587 | |
| SRP193095 | SRP14 | 6727 | RNAseq | -0.6408 | 0.0001 | |
| SRP219564 | SRP14 | 6727 | RNAseq | -0.6228 | 0.0341 | |
| TCGA | SRP14 | 6727 | RNAseq | -0.0142 | 0.7327 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRP14 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRP14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRP14 | 6727 | 4 | 5 | 21 | |
| GSE20123 | SRP14 | 6727 | 4 | 5 | 21 | |
| GSE43470 | SRP14 | 6727 | 4 | 6 | 33 | |
| GSE46452 | SRP14 | 6727 | 3 | 7 | 49 | |
| GSE47630 | SRP14 | 6727 | 8 | 11 | 21 | |
| GSE54993 | SRP14 | 6727 | 4 | 6 | 60 | |
| GSE54994 | SRP14 | 6727 | 5 | 7 | 41 | |
| GSE60625 | SRP14 | 6727 | 4 | 0 | 7 | |
| GSE74703 | SRP14 | 6727 | 4 | 5 | 27 | |
| GSE74704 | SRP14 | 6727 | 3 | 3 | 14 | |
| TCGA | SRP14 | 6727 | 11 | 17 | 68 |
Total number of gains: 54; Total number of losses: 72; Total Number of normals: 362.
Somatic mutations of SRP14:
Generating mutation plots.
Highly correlated genes for SRP14:
Showing top 20/706 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRP14 | VDAC3 | 0.842257 | 3 | 0 | 3 |
| SRP14 | PLEKHA5 | 0.789675 | 3 | 0 | 3 |
| SRP14 | YAP1 | 0.761625 | 4 | 0 | 3 |
| SRP14 | NACA2 | 0.759332 | 3 | 0 | 3 |
| SRP14 | ESYT2 | 0.748559 | 3 | 0 | 3 |
| SRP14 | RNF185 | 0.746499 | 3 | 0 | 3 |
| SRP14 | SERF2 | 0.734129 | 4 | 0 | 4 |
| SRP14 | FGD4 | 0.727838 | 4 | 0 | 3 |
| SRP14 | FAM219B | 0.726225 | 4 | 0 | 4 |
| SRP14 | COX7B | 0.70592 | 3 | 0 | 3 |
| SRP14 | PORCN | 0.705065 | 3 | 0 | 3 |
| SRP14 | ZNF436 | 0.703215 | 3 | 0 | 3 |
| SRP14 | SHROOM3 | 0.70209 | 5 | 0 | 5 |
| SRP14 | ACRBP | 0.701489 | 3 | 0 | 3 |
| SRP14 | UBE4A | 0.696497 | 3 | 0 | 3 |
| SRP14 | N6AMT1 | 0.695821 | 3 | 0 | 3 |
| SRP14 | RBM20 | 0.691768 | 3 | 0 | 3 |
| SRP14 | BHLHE40 | 0.689421 | 4 | 0 | 3 |
| SRP14 | COPS6 | 0.686689 | 5 | 0 | 4 |
| SRP14 | STXBP5 | 0.683624 | 3 | 0 | 3 |
For details and further investigation, click here
