| Full name: parvin beta | Alias Symbol: CGI-56 | ||
| Type: protein-coding gene | Cytoband: 22q13.31 | ||
| Entrez ID: 29780 | HGNC ID: HGNC:14653 | Ensembl Gene: ENSG00000188677 | OMIM ID: 608121 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PARVB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04510 | Focal adhesion |
Expression of PARVB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PARVB | 29780 | 37965_at | 0.3743 | 0.4673 | |
| GSE20347 | PARVB | 29780 | 204629_at | 0.8824 | 0.0033 | |
| GSE23400 | PARVB | 29780 | 204629_at | 0.2636 | 0.0007 | |
| GSE26886 | PARVB | 29780 | 229822_at | 0.7876 | 0.0017 | |
| GSE29001 | PARVB | 29780 | 37966_at | 0.9685 | 0.0047 | |
| GSE38129 | PARVB | 29780 | 37966_at | 0.8401 | 0.0022 | |
| GSE45670 | PARVB | 29780 | 229822_at | -0.5355 | 0.0107 | |
| GSE53622 | PARVB | 29780 | 70471 | 0.5318 | 0.0003 | |
| GSE53624 | PARVB | 29780 | 70471 | 1.2097 | 0.0000 | |
| GSE63941 | PARVB | 29780 | 37966_at | -0.4289 | 0.6072 | |
| GSE77861 | PARVB | 29780 | 37965_at | 0.4065 | 0.0023 | |
| GSE97050 | PARVB | 29780 | A_23_P40718 | 0.3145 | 0.2579 | |
| SRP064894 | PARVB | 29780 | RNAseq | 1.3162 | 0.0001 | |
| SRP133303 | PARVB | 29780 | RNAseq | 0.5450 | 0.0237 | |
| SRP159526 | PARVB | 29780 | RNAseq | 0.9939 | 0.0212 | |
| SRP193095 | PARVB | 29780 | RNAseq | 1.8389 | 0.0000 | |
| SRP219564 | PARVB | 29780 | RNAseq | 0.6000 | 0.2997 | |
| TCGA | PARVB | 29780 | RNAseq | 0.0184 | 0.8666 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PARVB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PARVB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PARVB | 29780 | 5 | 7 | 18 | |
| GSE20123 | PARVB | 29780 | 4 | 6 | 20 | |
| GSE43470 | PARVB | 29780 | 3 | 6 | 34 | |
| GSE46452 | PARVB | 29780 | 31 | 2 | 26 | |
| GSE47630 | PARVB | 29780 | 9 | 4 | 27 | |
| GSE54993 | PARVB | 29780 | 3 | 6 | 61 | |
| GSE54994 | PARVB | 29780 | 11 | 8 | 34 | |
| GSE60625 | PARVB | 29780 | 5 | 0 | 6 | |
| GSE74703 | PARVB | 29780 | 3 | 4 | 29 | |
| GSE74704 | PARVB | 29780 | 2 | 3 | 15 | |
| TCGA | PARVB | 29780 | 26 | 15 | 55 |
Total number of gains: 102; Total number of losses: 61; Total Number of normals: 325.
Somatic mutations of PARVB:
Generating mutation plots.
Highly correlated genes for PARVB:
Showing top 20/1517 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PARVB | KRTCAP2 | 0.828736 | 3 | 0 | 3 |
| PARVB | CRTC2 | 0.824652 | 3 | 0 | 3 |
| PARVB | WDR81 | 0.816258 | 3 | 0 | 3 |
| PARVB | SSBP4 | 0.815798 | 3 | 0 | 3 |
| PARVB | RFTN2 | 0.794405 | 3 | 0 | 3 |
| PARVB | HINT1 | 0.779276 | 3 | 0 | 3 |
| PARVB | DUS3L | 0.77054 | 3 | 0 | 3 |
| PARVB | GCLC | 0.769982 | 3 | 0 | 3 |
| PARVB | DAG1 | 0.769728 | 3 | 0 | 3 |
| PARVB | GHDC | 0.769109 | 3 | 0 | 3 |
| PARVB | EFTUD2 | 0.75973 | 4 | 0 | 4 |
| PARVB | ALKBH6 | 0.759177 | 3 | 0 | 3 |
| PARVB | TOP1MT | 0.747425 | 4 | 0 | 4 |
| PARVB | LRRC58 | 0.743509 | 3 | 0 | 3 |
| PARVB | TEX10 | 0.742532 | 3 | 0 | 3 |
| PARVB | RILPL1 | 0.736833 | 3 | 0 | 3 |
| PARVB | SLCO3A1 | 0.735471 | 3 | 0 | 3 |
| PARVB | USP28 | 0.734678 | 3 | 0 | 3 |
| PARVB | TMTC4 | 0.732733 | 3 | 0 | 3 |
| PARVB | TPM3 | 0.728857 | 3 | 0 | 3 |
For details and further investigation, click here
