NFATC1

 

Full name: nuclear factor of activated T cells 1 Alias Symbol: NF-ATC|NFATc|NFAT2
Type: protein-coding gene Cytoband: 18q23
Entrez ID: 4772 HGNC ID: HGNC:7775 Ensembl Gene: ENSG00000131196 OMIM ID: 600489
Drug and gene relationship at DGIdb

 

NFATC1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04310Wnt signaling pathway
hsa04380Osteoclast differentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04921Oxytocin signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05321Inflammatory bowel disease (IBD)

 

Expression of NFATC1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NFATC1 4772 211105_s_at 0.0555 0.9494
GSE20347 NFATC1 4772 208196_x_at -0.0043 0.9654
GSE23400 NFATC1 4772 211105_s_at 0.0946 0.1785
GSE26886 NFATC1 4772 211105_s_at 2.1269 0.0000
GSE29001 NFATC1 4772 211105_s_at 0.9852 0.0019
GSE38129 NFATC1 4772 211105_s_at 0.6188 0.0317
GSE45670 NFATC1 4772 208196_x_at -0.0554 0.5186
GSE53622 NFATC1 4772 152937 0.5358 0.0001
GSE53624 NFATC1 4772 152937 0.8186 0.0000
GSE63941 NFATC1 4772 211105_s_at -1.1491 0.0243
GSE77861 NFATC1 4772 208196_x_at 0.0173 0.9245
GSE97050 NFATC1 4772 A_24_P258846 0.4374 0.3240
SRP007169 NFATC1 4772 RNAseq 3.3885 0.0025
SRP064894 NFATC1 4772 RNAseq 0.5903 0.0410
SRP133303 NFATC1 4772 RNAseq -0.0978 0.6342
SRP159526 NFATC1 4772 RNAseq 1.3239 0.0288
SRP193095 NFATC1 4772 RNAseq 1.9242 0.0000
TCGA NFATC1 4772 RNAseq -0.1457 0.1352

Upregulated datasets: 4; Downregulated datasets: 1.  

 

Survival by NFATC1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NFATC1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NFATC1 4772 1 12 17
GSE20123 NFATC1 4772 1 12 17
GSE43470 NFATC1 4772 0 12 31
GSE46452 NFATC1 4772 1 26 32
GSE47630 NFATC1 4772 5 22 13
GSE54993 NFATC1 4772 9 0 61
GSE54994 NFATC1 4772 1 19 33
GSE60625 NFATC1 4772 0 4 7
GSE74703 NFATC1 4772 0 8 28
GSE74704 NFATC1 4772 0 9 11
TCGA NFATC1 4772 7 45 44

Total number of gains: 25; Total number of losses: 169; Total Number of normals: 294.  

 

Somatic mutations of NFATC1:

 

Generating mutation plots.

 

Highly correlated genes for NFATC1:

 

Showing top 20/814 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NFATC1LMO10.819813303
NFATC1GNA130.807808303
NFATC1XKR80.778049303
NFATC1MRM10.760986303
NFATC1TMTC10.747167404
NFATC1TMEM920.737291303
NFATC1C15orf610.727855303
NFATC1C7orf500.723085303
NFATC1GLIS20.721198505
NFATC1ITM2C0.720245807
NFATC1IDS0.720125403
NFATC1SLC25A420.71901303
NFATC1JTB0.718809303
NFATC1CHST150.718788706
NFATC1ZNF8270.714235403
NFATC1SH3RF30.713406403
NFATC1DOCK110.712696403
NFATC1A4GALT0.712079303
NFATC1HINT10.711791303
NFATC1FXR10.711364404

For details and further investigation, click here