| Full name: major histocompatibility complex, class II, DP beta 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 3115 | HGNC ID: HGNC:4940 | Ensembl Gene: ENSG00000223865 | OMIM ID: 142858 |
| Drug and gene relationship at DGIdb | |||
HLA-DPB1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05152 | Tuberculosis |
Expression of HLA-DPB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-DPB1 | 3115 | 201137_s_at | -0.3950 | 0.7789 | |
| GSE20347 | HLA-DPB1 | 3115 | 201137_s_at | -0.6965 | 0.0155 | |
| GSE23400 | HLA-DPB1 | 3115 | 201137_s_at | -0.0658 | 0.7416 | |
| GSE26886 | HLA-DPB1 | 3115 | 201137_s_at | -1.2898 | 0.0108 | |
| GSE29001 | HLA-DPB1 | 3115 | 201137_s_at | -0.1377 | 0.7586 | |
| GSE38129 | HLA-DPB1 | 3115 | 201137_s_at | -0.5703 | 0.0527 | |
| GSE45670 | HLA-DPB1 | 3115 | 201137_s_at | -0.9060 | 0.0500 | |
| GSE53622 | HLA-DPB1 | 3115 | 84956 | -0.2059 | 0.1609 | |
| GSE53624 | HLA-DPB1 | 3115 | 84956 | -0.3462 | 0.0053 | |
| GSE63941 | HLA-DPB1 | 3115 | 201137_s_at | -1.6676 | 0.0098 | |
| GSE77861 | HLA-DPB1 | 3115 | 201137_s_at | -0.6052 | 0.0725 | |
| GSE97050 | HLA-DPB1 | 3115 | A_33_P3271635 | 0.6188 | 0.2344 | |
| SRP007169 | HLA-DPB1 | 3115 | RNAseq | -0.1910 | 0.7684 | |
| SRP008496 | HLA-DPB1 | 3115 | RNAseq | -0.4160 | 0.3264 | |
| SRP064894 | HLA-DPB1 | 3115 | RNAseq | 0.3878 | 0.3257 | |
| SRP133303 | HLA-DPB1 | 3115 | RNAseq | -0.3381 | 0.1421 | |
| SRP159526 | HLA-DPB1 | 3115 | RNAseq | -0.8951 | 0.2390 | |
| SRP193095 | HLA-DPB1 | 3115 | RNAseq | -0.5449 | 0.0124 | |
| SRP219564 | HLA-DPB1 | 3115 | RNAseq | 0.9720 | 0.0010 | |
| TCGA | HLA-DPB1 | 3115 | RNAseq | 0.0242 | 0.8476 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by HLA-DPB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-DPB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-DPB1 | 3115 | 5 | 0 | 25 | |
| GSE20123 | HLA-DPB1 | 3115 | 5 | 0 | 25 | |
| GSE43470 | HLA-DPB1 | 3115 | 4 | 1 | 38 | |
| GSE46452 | HLA-DPB1 | 3115 | 2 | 9 | 48 | |
| GSE47630 | HLA-DPB1 | 3115 | 8 | 4 | 28 | |
| GSE54993 | HLA-DPB1 | 3115 | 3 | 1 | 66 | |
| GSE54994 | HLA-DPB1 | 3115 | 11 | 4 | 38 | |
| GSE60625 | HLA-DPB1 | 3115 | 1 | 0 | 10 | |
| GSE74703 | HLA-DPB1 | 3115 | 4 | 0 | 32 | |
| GSE74704 | HLA-DPB1 | 3115 | 2 | 0 | 18 |
Total number of gains: 45; Total number of losses: 19; Total Number of normals: 328.
Somatic mutations of HLA-DPB1:
Generating mutation plots.
Highly correlated genes for HLA-DPB1:
Showing top 20/526 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-DPB1 | HLA-DRA | 0.809799 | 13 | 0 | 12 |
| HLA-DPB1 | HLA-DMA | 0.802846 | 13 | 0 | 13 |
| HLA-DPB1 | CD74 | 0.775799 | 13 | 0 | 12 |
| HLA-DPB1 | TNFSF8 | 0.761257 | 4 | 0 | 4 |
| HLA-DPB1 | HLA-DPA1 | 0.746401 | 13 | 0 | 12 |
| HLA-DPB1 | ATMIN | 0.743526 | 3 | 0 | 3 |
| HLA-DPB1 | HLA-DQB1 | 0.742911 | 13 | 0 | 12 |
| HLA-DPB1 | HLA-DMB | 0.724692 | 13 | 0 | 11 |
| HLA-DPB1 | OSTC | 0.710231 | 3 | 0 | 3 |
| HLA-DPB1 | MPEG1 | 0.707937 | 7 | 0 | 7 |
| HLA-DPB1 | CD48 | 0.704502 | 10 | 0 | 10 |
| HLA-DPB1 | TSTA3 | 0.704031 | 3 | 0 | 3 |
| HLA-DPB1 | PTPRC | 0.700426 | 9 | 0 | 9 |
| HLA-DPB1 | CD2 | 0.699591 | 11 | 0 | 10 |
| HLA-DPB1 | MS4A6A | 0.699529 | 11 | 0 | 10 |
| HLA-DPB1 | SLAMF6 | 0.693232 | 5 | 0 | 5 |
| HLA-DPB1 | GIMAP7 | 0.692205 | 7 | 0 | 6 |
| HLA-DPB1 | C1orf162 | 0.691319 | 7 | 0 | 7 |
| HLA-DPB1 | MTPN | 0.68589 | 3 | 0 | 3 |
| HLA-DPB1 | OR7E24 | 0.684194 | 3 | 0 | 3 |
For details and further investigation, click here
