| Full name: major histocompatibility complex, class II, DM beta | Alias Symbol: D6S221E|RING7 | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 3109 | HGNC ID: HGNC:4935 | Ensembl Gene: ENSG00000242574 | OMIM ID: 142856 |
| Drug and gene relationship at DGIdb | |||
HLA-DMB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05152 | Tuberculosis |
Expression of HLA-DMB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-DMB | 3109 | 203932_at | 0.2117 | 0.8648 | |
| GSE20347 | HLA-DMB | 3109 | 203932_at | 0.2323 | 0.3164 | |
| GSE23400 | HLA-DMB | 3109 | 203932_at | 0.2759 | 0.0145 | |
| GSE26886 | HLA-DMB | 3109 | 203932_at | -0.1851 | 0.6914 | |
| GSE29001 | HLA-DMB | 3109 | 203932_at | 0.2613 | 0.3877 | |
| GSE38129 | HLA-DMB | 3109 | 203932_at | 0.2266 | 0.3734 | |
| GSE45670 | HLA-DMB | 3109 | 203932_at | -0.2572 | 0.5609 | |
| GSE53622 | HLA-DMB | 3109 | 21130 | 0.2272 | 0.2603 | |
| GSE53624 | HLA-DMB | 3109 | 21130 | -0.0116 | 0.9574 | |
| GSE63941 | HLA-DMB | 3109 | 203932_at | -0.1295 | 0.9081 | |
| GSE77861 | HLA-DMB | 3109 | 203932_at | 0.0567 | 0.6694 | |
| GSE97050 | HLA-DMB | 3109 | A_32_P351968 | 0.9000 | 0.1921 | |
| SRP007169 | HLA-DMB | 3109 | RNAseq | 1.2308 | 0.1005 | |
| SRP008496 | HLA-DMB | 3109 | RNAseq | 0.8970 | 0.0436 | |
| SRP064894 | HLA-DMB | 3109 | RNAseq | 0.7475 | 0.0143 | |
| SRP133303 | HLA-DMB | 3109 | RNAseq | 0.2521 | 0.3613 | |
| SRP159526 | HLA-DMB | 3109 | RNAseq | -0.2837 | 0.7305 | |
| SRP193095 | HLA-DMB | 3109 | RNAseq | 0.0858 | 0.7608 | |
| SRP219564 | HLA-DMB | 3109 | RNAseq | 1.2734 | 0.0100 | |
| TCGA | HLA-DMB | 3109 | RNAseq | 0.1137 | 0.4256 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HLA-DMB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-DMB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-DMB | 3109 | 5 | 0 | 25 | |
| GSE20123 | HLA-DMB | 3109 | 5 | 0 | 25 | |
| GSE43470 | HLA-DMB | 3109 | 5 | 1 | 37 | |
| GSE46452 | HLA-DMB | 3109 | 2 | 9 | 48 | |
| GSE47630 | HLA-DMB | 3109 | 8 | 4 | 28 | |
| GSE54993 | HLA-DMB | 3109 | 3 | 1 | 66 | |
| GSE54994 | HLA-DMB | 3109 | 11 | 4 | 38 | |
| GSE60625 | HLA-DMB | 3109 | 1 | 0 | 10 | |
| GSE74703 | HLA-DMB | 3109 | 5 | 0 | 31 | |
| GSE74704 | HLA-DMB | 3109 | 2 | 0 | 18 |
Total number of gains: 47; Total number of losses: 19; Total Number of normals: 326.
Somatic mutations of HLA-DMB:
Generating mutation plots.
Highly correlated genes for HLA-DMB:
Showing top 20/476 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-DMB | HLA-DMA | 0.882053 | 12 | 0 | 12 |
| HLA-DMB | CD74 | 0.813161 | 12 | 0 | 11 |
| HLA-DMB | HLA-DRA | 0.781182 | 13 | 0 | 13 |
| HLA-DMB | HLA-DPA1 | 0.76541 | 13 | 0 | 12 |
| HLA-DMB | CERKL | 0.756606 | 3 | 0 | 3 |
| HLA-DMB | HLA-DQB1 | 0.753641 | 13 | 0 | 13 |
| HLA-DMB | C1orf162 | 0.751878 | 7 | 0 | 7 |
| HLA-DMB | LAPTM5 | 0.75183 | 12 | 0 | 12 |
| HLA-DMB | HAVCR2 | 0.751817 | 5 | 0 | 5 |
| HLA-DMB | GIMAP5 | 0.746098 | 4 | 0 | 4 |
| HLA-DMB | CD84 | 0.743073 | 9 | 0 | 8 |
| HLA-DMB | C16orf54 | 0.741198 | 7 | 0 | 7 |
| HLA-DMB | GPR141 | 0.736276 | 3 | 0 | 3 |
| HLA-DMB | IRF8 | 0.735807 | 12 | 0 | 11 |
| HLA-DMB | MS4A6A | 0.73553 | 10 | 0 | 10 |
| HLA-DMB | AIF1 | 0.732169 | 11 | 0 | 11 |
| HLA-DMB | ARHGDIB | 0.728593 | 11 | 0 | 10 |
| HLA-DMB | IL2RA | 0.728502 | 4 | 0 | 4 |
| HLA-DMB | ITGB2 | 0.726185 | 12 | 0 | 10 |
| HLA-DMB | LCP1 | 0.725491 | 11 | 0 | 10 |
For details and further investigation, click here
