| Full name: LDL receptor related protein 3 | Alias Symbol: LRP-3|hLRp105 | ||
| Type: protein-coding gene | Cytoband: 19q13.11 | ||
| Entrez ID: 4037 | HGNC ID: HGNC:6695 | Ensembl Gene: ENSG00000130881 | OMIM ID: 603159 |
Expression of LRP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRP3 | 4037 | 204381_at | 0.5165 | 0.2230 | |
| GSE20347 | LRP3 | 4037 | 204381_at | 0.4772 | 0.0014 | |
| GSE23400 | LRP3 | 4037 | 204381_at | 0.1099 | 0.0524 | |
| GSE26886 | LRP3 | 4037 | 204381_at | 1.1350 | 0.0000 | |
| GSE29001 | LRP3 | 4037 | 204381_at | 0.1671 | 0.4578 | |
| GSE38129 | LRP3 | 4037 | 204381_at | 0.3391 | 0.0639 | |
| GSE45670 | LRP3 | 4037 | 204381_at | -0.0451 | 0.7857 | |
| GSE63941 | LRP3 | 4037 | 204381_at | -1.4493 | 0.0012 | |
| GSE77861 | LRP3 | 4037 | 204381_at | 0.1552 | 0.4335 | |
| GSE97050 | LRP3 | 4037 | A_23_P16415 | -0.0863 | 0.7171 | |
| SRP007169 | LRP3 | 4037 | RNAseq | 0.0923 | 0.8796 | |
| SRP008496 | LRP3 | 4037 | RNAseq | 0.9720 | 0.0473 | |
| SRP064894 | LRP3 | 4037 | RNAseq | 0.8230 | 0.0521 | |
| SRP133303 | LRP3 | 4037 | RNAseq | 0.1248 | 0.6542 | |
| SRP159526 | LRP3 | 4037 | RNAseq | 1.2956 | 0.0002 | |
| SRP193095 | LRP3 | 4037 | RNAseq | 1.0129 | 0.0000 | |
| TCGA | LRP3 | 4037 | RNAseq | -0.0687 | 0.4865 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by LRP3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of LRP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRP3 | 4037 | 7 | 6 | 17 | |
| GSE20123 | LRP3 | 4037 | 7 | 5 | 18 | |
| GSE43470 | LRP3 | 4037 | 4 | 6 | 33 | |
| GSE46452 | LRP3 | 4037 | 47 | 1 | 11 | |
| GSE47630 | LRP3 | 4037 | 8 | 6 | 26 | |
| GSE54993 | LRP3 | 4037 | 17 | 3 | 50 | |
| GSE54994 | LRP3 | 4037 | 7 | 9 | 37 | |
| GSE60625 | LRP3 | 4037 | 9 | 0 | 2 | |
| GSE74703 | LRP3 | 4037 | 4 | 4 | 28 | |
| GSE74704 | LRP3 | 4037 | 6 | 3 | 11 | |
| TCGA | LRP3 | 4037 | 18 | 12 | 66 |
Total number of gains: 134; Total number of losses: 55; Total Number of normals: 299.
Somatic mutations of LRP3:
Generating mutation plots.
Highly correlated genes for LRP3:
Showing top 20/1148 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRP3 | BBX | 0.831605 | 3 | 0 | 3 |
| LRP3 | SLC39A13 | 0.79062 | 5 | 0 | 5 |
| LRP3 | C19orf18 | 0.790377 | 3 | 0 | 3 |
| LRP3 | ZNF71 | 0.774829 | 3 | 0 | 3 |
| LRP3 | GFRA1 | 0.771278 | 3 | 0 | 3 |
| LRP3 | HMCN1 | 0.761686 | 3 | 0 | 3 |
| LRP3 | NAF1 | 0.73722 | 3 | 0 | 3 |
| LRP3 | SH3RF3 | 0.728015 | 4 | 0 | 4 |
| LRP3 | SSBP4 | 0.727301 | 6 | 0 | 5 |
| LRP3 | KDSR | 0.720649 | 3 | 0 | 3 |
| LRP3 | TCTN3 | 0.720434 | 3 | 0 | 3 |
| LRP3 | GPR3 | 0.719656 | 3 | 0 | 3 |
| LRP3 | TCF21 | 0.718159 | 3 | 0 | 3 |
| LRP3 | LRRN4CL | 0.71686 | 3 | 0 | 3 |
| LRP3 | PXYLP1 | 0.716812 | 3 | 0 | 3 |
| LRP3 | C20orf194 | 0.714981 | 3 | 0 | 3 |
| LRP3 | BRPF3 | 0.710788 | 3 | 0 | 3 |
| LRP3 | DOK6 | 0.709988 | 3 | 0 | 3 |
| LRP3 | LIFR | 0.707368 | 3 | 0 | 3 |
| LRP3 | KBTBD6 | 0.705959 | 3 | 0 | 3 |
For details and further investigation, click here
