| Full name: high mobility group box 4 | Alias Symbol: FLJ40388 | ||
| Type: protein-coding gene | Cytoband: 1p35.1 | ||
| Entrez ID: 127540 | HGNC ID: HGNC:24954 | Ensembl Gene: ENSG00000176256 | OMIM ID: 617285 |
| Drug and gene relationship at DGIdb | |||
Expression of HMGB4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMGB4 | 127540 | 230473_s_at | -0.1102 | 0.5634 | |
| GSE26886 | HMGB4 | 127540 | 230473_s_at | 0.2634 | 0.0293 | |
| GSE45670 | HMGB4 | 127540 | 230473_s_at | 0.0722 | 0.4152 | |
| GSE53622 | HMGB4 | 127540 | 70718 | -1.6296 | 0.0000 | |
| GSE53624 | HMGB4 | 127540 | 70718 | -2.2149 | 0.0000 | |
| GSE63941 | HMGB4 | 127540 | 230473_s_at | 0.0590 | 0.7206 | |
| GSE77861 | HMGB4 | 127540 | 230473_s_at | -0.0503 | 0.6626 | |
| GSE97050 | HMGB4 | 127540 | A_23_P11697 | -0.0287 | 0.9089 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by HMGB4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMGB4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMGB4 | 127540 | 2 | 5 | 23 | |
| GSE20123 | HMGB4 | 127540 | 2 | 4 | 24 | |
| GSE43470 | HMGB4 | 127540 | 5 | 4 | 34 | |
| GSE46452 | HMGB4 | 127540 | 4 | 1 | 54 | |
| GSE47630 | HMGB4 | 127540 | 8 | 3 | 29 | |
| GSE54993 | HMGB4 | 127540 | 1 | 1 | 68 | |
| GSE54994 | HMGB4 | 127540 | 11 | 2 | 40 | |
| GSE60625 | HMGB4 | 127540 | 0 | 0 | 11 | |
| GSE74703 | HMGB4 | 127540 | 4 | 3 | 29 | |
| GSE74704 | HMGB4 | 127540 | 1 | 0 | 19 | |
| TCGA | HMGB4 | 127540 | 12 | 18 | 66 |
Total number of gains: 50; Total number of losses: 41; Total Number of normals: 397.
Somatic mutations of HMGB4:
Generating mutation plots.
Highly correlated genes for HMGB4:
Showing top 20/228 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMGB4 | FAM163B | 0.839612 | 3 | 0 | 3 |
| HMGB4 | KCNK7 | 0.830419 | 3 | 0 | 3 |
| HMGB4 | RNF222 | 0.828457 | 3 | 0 | 3 |
| HMGB4 | NOTO | 0.817071 | 3 | 0 | 3 |
| HMGB4 | HES5 | 0.814056 | 3 | 0 | 3 |
| HMGB4 | GHRHR | 0.81388 | 3 | 0 | 3 |
| HMGB4 | BARHL2 | 0.803538 | 3 | 0 | 3 |
| HMGB4 | SLC25A47 | 0.792172 | 3 | 0 | 3 |
| HMGB4 | CLEC18C | 0.7849 | 3 | 0 | 3 |
| HMGB4 | NCR1 | 0.782594 | 3 | 0 | 3 |
| HMGB4 | C3orf20 | 0.77866 | 4 | 0 | 4 |
| HMGB4 | KCNA7 | 0.777469 | 4 | 0 | 4 |
| HMGB4 | MFSD2B | 0.7757 | 3 | 0 | 3 |
| HMGB4 | FOXB1 | 0.773658 | 3 | 0 | 3 |
| HMGB4 | KPRP | 0.771034 | 3 | 0 | 3 |
| HMGB4 | NCCRP1 | 0.770666 | 3 | 0 | 3 |
| HMGB4 | OR2Z1 | 0.763108 | 3 | 0 | 3 |
| HMGB4 | CD164L2 | 0.754679 | 3 | 0 | 3 |
| HMGB4 | OTOP3 | 0.753717 | 3 | 0 | 3 |
| HMGB4 | C16orf89 | 0.752419 | 3 | 0 | 3 |
For details and further investigation, click here
