| Full name: mitochondrial ribosome recycling factor | Alias Symbol: RRF | ||
| Type: protein-coding gene | Cytoband: 9q33.2 | ||
| Entrez ID: 92399 | HGNC ID: HGNC:7234 | Ensembl Gene: ENSG00000148187 | OMIM ID: 604602 |
| Drug and gene relationship at DGIdb | |||
Expression of MRRF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRRF | 92399 | 225126_at | -0.1361 | 0.7140 | |
| GSE26886 | MRRF | 92399 | 225126_at | 0.3027 | 0.0542 | |
| GSE45670 | MRRF | 92399 | 225126_at | 0.2518 | 0.0388 | |
| GSE53622 | MRRF | 92399 | 20489 | 0.1182 | 0.1437 | |
| GSE53624 | MRRF | 92399 | 55798 | 0.1634 | 0.0560 | |
| GSE63941 | MRRF | 92399 | 225126_at | 1.8299 | 0.0008 | |
| GSE77861 | MRRF | 92399 | 225126_at | 0.0724 | 0.7975 | |
| GSE97050 | MRRF | 92399 | A_33_P3398809 | 0.1805 | 0.5857 | |
| SRP007169 | MRRF | 92399 | RNAseq | 0.2322 | 0.6938 | |
| SRP008496 | MRRF | 92399 | RNAseq | -0.0178 | 0.9613 | |
| SRP064894 | MRRF | 92399 | RNAseq | 0.2948 | 0.0513 | |
| SRP133303 | MRRF | 92399 | RNAseq | 0.0423 | 0.8227 | |
| SRP159526 | MRRF | 92399 | RNAseq | -0.2609 | 0.1179 | |
| SRP193095 | MRRF | 92399 | RNAseq | -0.1915 | 0.0637 | |
| SRP219564 | MRRF | 92399 | RNAseq | 0.2789 | 0.4903 | |
| TCGA | MRRF | 92399 | RNAseq | 0.1460 | 0.0193 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MRRF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRRF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRRF | 92399 | 3 | 7 | 20 | |
| GSE20123 | MRRF | 92399 | 3 | 7 | 20 | |
| GSE43470 | MRRF | 92399 | 6 | 3 | 34 | |
| GSE46452 | MRRF | 92399 | 6 | 13 | 40 | |
| GSE47630 | MRRF | 92399 | 3 | 16 | 21 | |
| GSE54993 | MRRF | 92399 | 3 | 3 | 64 | |
| GSE54994 | MRRF | 92399 | 9 | 10 | 34 | |
| GSE60625 | MRRF | 92399 | 0 | 0 | 11 | |
| GSE74703 | MRRF | 92399 | 5 | 3 | 28 | |
| GSE74704 | MRRF | 92399 | 2 | 5 | 13 | |
| TCGA | MRRF | 92399 | 27 | 24 | 45 |
Total number of gains: 67; Total number of losses: 91; Total Number of normals: 330.
Somatic mutations of MRRF:
Generating mutation plots.
Highly correlated genes for MRRF:
Showing top 20/255 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRRF | MRPL42 | 0.838263 | 3 | 0 | 3 |
| MRRF | HCCS | 0.79363 | 3 | 0 | 3 |
| MRRF | TMEM170A | 0.765357 | 3 | 0 | 3 |
| MRRF | ZNF394 | 0.762247 | 3 | 0 | 3 |
| MRRF | PPP6C | 0.760418 | 4 | 0 | 4 |
| MRRF | HMGCS1 | 0.757239 | 3 | 0 | 3 |
| MRRF | C1orf56 | 0.754302 | 4 | 0 | 4 |
| MRRF | PAIP2 | 0.753363 | 3 | 0 | 3 |
| MRRF | CNOT1 | 0.750268 | 3 | 0 | 3 |
| MRRF | MTCH2 | 0.740891 | 3 | 0 | 3 |
| MRRF | RPS14 | 0.73644 | 3 | 0 | 3 |
| MRRF | ERP44 | 0.735828 | 3 | 0 | 3 |
| MRRF | CDC42SE1 | 0.723743 | 3 | 0 | 3 |
| MRRF | ATP6V1G1 | 0.716012 | 4 | 0 | 3 |
| MRRF | UQCR10 | 0.710114 | 3 | 0 | 3 |
| MRRF | NAA35 | 0.706677 | 3 | 0 | 3 |
| MRRF | DNAH1 | 0.704922 | 3 | 0 | 3 |
| MRRF | PCK2 | 0.703984 | 3 | 0 | 3 |
| MRRF | ANKRD11 | 0.701989 | 3 | 0 | 3 |
| MRRF | POLE3 | 0.699048 | 7 | 0 | 7 |
For details and further investigation, click here
