| Full name: aminoadipate-semialdehyde dehydrogenase | Alias Symbol: NRPS998|LYS2|ACSF4 | ||
| Type: protein-coding gene | Cytoband: 4q12 | ||
| Entrez ID: 132949 | HGNC ID: HGNC:23993 | Ensembl Gene: ENSG00000157426 | OMIM ID: 614365 |
| Drug and gene relationship at DGIdb | |||
Expression of AASDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AASDH | 132949 | 235435_at | -0.0581 | 0.9072 | |
| GSE26886 | AASDH | 132949 | 228041_at | -0.8335 | 0.0006 | |
| GSE45670 | AASDH | 132949 | 235435_at | 0.1047 | 0.7692 | |
| GSE53622 | AASDH | 132949 | 80677 | 0.1690 | 0.0338 | |
| GSE53624 | AASDH | 132949 | 80677 | -0.0083 | 0.9320 | |
| GSE63941 | AASDH | 132949 | 235435_at | -0.5692 | 0.2753 | |
| GSE77861 | AASDH | 132949 | 228041_at | -0.0328 | 0.9476 | |
| GSE97050 | AASDH | 132949 | A_24_P383076 | 0.2471 | 0.2729 | |
| SRP007169 | AASDH | 132949 | RNAseq | -0.5876 | 0.2254 | |
| SRP008496 | AASDH | 132949 | RNAseq | -0.2675 | 0.3325 | |
| SRP064894 | AASDH | 132949 | RNAseq | -0.0798 | 0.6109 | |
| SRP133303 | AASDH | 132949 | RNAseq | 0.2942 | 0.1989 | |
| SRP159526 | AASDH | 132949 | RNAseq | -0.2980 | 0.2293 | |
| SRP193095 | AASDH | 132949 | RNAseq | -0.3457 | 0.0039 | |
| SRP219564 | AASDH | 132949 | RNAseq | -0.3672 | 0.1482 | |
| TCGA | AASDH | 132949 | RNAseq | 0.0527 | 0.4214 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AASDH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AASDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AASDH | 132949 | 3 | 12 | 15 | |
| GSE20123 | AASDH | 132949 | 2 | 12 | 16 | |
| GSE43470 | AASDH | 132949 | 0 | 14 | 29 | |
| GSE46452 | AASDH | 132949 | 1 | 36 | 22 | |
| GSE47630 | AASDH | 132949 | 0 | 19 | 21 | |
| GSE54993 | AASDH | 132949 | 7 | 0 | 63 | |
| GSE54994 | AASDH | 132949 | 2 | 10 | 41 | |
| GSE60625 | AASDH | 132949 | 0 | 0 | 11 | |
| GSE74703 | AASDH | 132949 | 0 | 12 | 24 | |
| GSE74704 | AASDH | 132949 | 1 | 7 | 12 | |
| TCGA | AASDH | 132949 | 20 | 27 | 49 |
Total number of gains: 36; Total number of losses: 149; Total Number of normals: 303.
Somatic mutations of AASDH:
Generating mutation plots.
Highly correlated genes for AASDH:
Showing top 20/123 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AASDH | ATXN3 | 0.709645 | 3 | 0 | 3 |
| AASDH | HOOK1 | 0.701061 | 3 | 0 | 3 |
| AASDH | DCAF11 | 0.699718 | 4 | 0 | 3 |
| AASDH | NAT1 | 0.67907 | 3 | 0 | 3 |
| AASDH | BRI3BP | 0.671178 | 3 | 0 | 3 |
| AASDH | WDFY1 | 0.666872 | 3 | 0 | 3 |
| AASDH | ARF6 | 0.663646 | 3 | 0 | 3 |
| AASDH | EXOC1 | 0.651113 | 7 | 0 | 5 |
| AASDH | CHMP4C | 0.649327 | 3 | 0 | 3 |
| AASDH | THAP1 | 0.640344 | 4 | 0 | 4 |
| AASDH | CARD16 | 0.638423 | 3 | 0 | 3 |
| AASDH | RASGRP1 | 0.638323 | 3 | 0 | 3 |
| AASDH | KLHL28 | 0.631509 | 3 | 0 | 3 |
| AASDH | STX18 | 0.628529 | 3 | 0 | 3 |
| AASDH | GTF2A1 | 0.628132 | 3 | 0 | 3 |
| AASDH | PRPF39 | 0.627967 | 4 | 0 | 3 |
| AASDH | NOA1 | 0.627066 | 6 | 0 | 5 |
| AASDH | PEX2 | 0.623978 | 5 | 0 | 4 |
| AASDH | POLR2B | 0.621719 | 8 | 0 | 5 |
| AASDH | CENPC | 0.621453 | 4 | 0 | 3 |
For details and further investigation, click here
