| Full name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | Alias Symbol: PARX | ||
| Type: protein-coding gene | Cytoband: 4p14 | ||
| Entrez ID: 116984 | HGNC ID: HGNC:16924 | Ensembl Gene: ENSG00000047365 | OMIM ID: 606645 |
| Drug and gene relationship at DGIdb | |||
Expression of ARAP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | ARAP2 | 116984 | 52294 | -0.7776 | 0.0000 | |
| GSE53624 | ARAP2 | 116984 | 52294 | -1.1253 | 0.0000 | |
| GSE97050 | ARAP2 | 116984 | A_32_P83784 | 0.2258 | 0.6701 | |
| SRP007169 | ARAP2 | 116984 | RNAseq | -1.3903 | 0.0003 | |
| SRP008496 | ARAP2 | 116984 | RNAseq | -1.0356 | 0.0006 | |
| SRP064894 | ARAP2 | 116984 | RNAseq | -1.2786 | 0.0001 | |
| SRP133303 | ARAP2 | 116984 | RNAseq | -0.8241 | 0.0000 | |
| SRP159526 | ARAP2 | 116984 | RNAseq | -1.1661 | 0.0446 | |
| SRP193095 | ARAP2 | 116984 | RNAseq | -1.0260 | 0.0000 | |
| SRP219564 | ARAP2 | 116984 | RNAseq | -1.0633 | 0.1593 | |
| TCGA | ARAP2 | 116984 | RNAseq | 0.1444 | 0.1330 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by ARAP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARAP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARAP2 | 116984 | 0 | 18 | 12 | |
| GSE20123 | ARAP2 | 116984 | 0 | 17 | 13 | |
| GSE43470 | ARAP2 | 116984 | 0 | 14 | 29 | |
| GSE46452 | ARAP2 | 116984 | 1 | 37 | 21 | |
| GSE47630 | ARAP2 | 116984 | 1 | 19 | 20 | |
| GSE54993 | ARAP2 | 116984 | 9 | 0 | 61 | |
| GSE54994 | ARAP2 | 116984 | 4 | 10 | 39 | |
| GSE60625 | ARAP2 | 116984 | 0 | 0 | 11 | |
| GSE74703 | ARAP2 | 116984 | 0 | 12 | 24 | |
| GSE74704 | ARAP2 | 116984 | 0 | 11 | 9 | |
| TCGA | ARAP2 | 116984 | 10 | 47 | 39 |
Total number of gains: 25; Total number of losses: 185; Total Number of normals: 278.
Somatic mutations of ARAP2:
Generating mutation plots.
Highly correlated genes for ARAP2:
Showing top 20/371 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARAP2 | BTBD11 | 0.823378 | 3 | 0 | 3 |
| ARAP2 | DUOX1 | 0.822668 | 3 | 0 | 3 |
| ARAP2 | PRDM1 | 0.809019 | 3 | 0 | 3 |
| ARAP2 | KLF5 | 0.808951 | 3 | 0 | 3 |
| ARAP2 | SH3RF2 | 0.799225 | 3 | 0 | 3 |
| ARAP2 | EVPL | 0.797682 | 3 | 0 | 3 |
| ARAP2 | CTNNBIP1 | 0.795443 | 3 | 0 | 3 |
| ARAP2 | ARHGAP32 | 0.794925 | 3 | 0 | 3 |
| ARAP2 | FAM160A1 | 0.793899 | 3 | 0 | 3 |
| ARAP2 | MACC1 | 0.786481 | 3 | 0 | 3 |
| ARAP2 | NBEAL2 | 0.784933 | 3 | 0 | 3 |
| ARAP2 | VAMP8 | 0.778905 | 3 | 0 | 3 |
| ARAP2 | CLDN7 | 0.776785 | 3 | 0 | 3 |
| ARAP2 | DSG3 | 0.773113 | 4 | 0 | 4 |
| ARAP2 | CDS1 | 0.773059 | 3 | 0 | 3 |
| ARAP2 | RAB27B | 0.771958 | 3 | 0 | 3 |
| ARAP2 | DAPP1 | 0.769725 | 3 | 0 | 3 |
| ARAP2 | JUP | 0.769658 | 3 | 0 | 3 |
| ARAP2 | SLC9A3R1 | 0.76844 | 3 | 0 | 3 |
| ARAP2 | PGLYRP3 | 0.767478 | 3 | 0 | 3 |
For details and further investigation, click here
