| Full name: homeobox B8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 3218 | HGNC ID: HGNC:5119 | Ensembl Gene: ENSG00000120068 | OMIM ID: 142963 |
| Drug and gene relationship at DGIdb | |||
Expression of HOXB8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HOXB8 | 3218 | 221278_at | 0.0678 | 0.8631 | |
| GSE20347 | HOXB8 | 3218 | 221278_at | 0.0212 | 0.7771 | |
| GSE23400 | HOXB8 | 3218 | 221278_at | -0.1492 | 0.0000 | |
| GSE26886 | HOXB8 | 3218 | 221278_at | 0.3046 | 0.0175 | |
| GSE29001 | HOXB8 | 3218 | 221278_at | 0.0209 | 0.8553 | |
| GSE38129 | HOXB8 | 3218 | 221278_at | 0.0301 | 0.6181 | |
| GSE45670 | HOXB8 | 3218 | 221278_at | 0.1036 | 0.2107 | |
| GSE53622 | HOXB8 | 3218 | 25789 | 0.5750 | 0.0001 | |
| GSE53624 | HOXB8 | 3218 | 25789 | 0.7611 | 0.0001 | |
| GSE63941 | HOXB8 | 3218 | 229667_s_at | 0.0760 | 0.7765 | |
| GSE77861 | HOXB8 | 3218 | 221278_at | -0.0275 | 0.7821 | |
| SRP159526 | HOXB8 | 3218 | RNAseq | 6.4715 | 0.0000 | |
| TCGA | HOXB8 | 3218 | RNAseq | 1.2625 | 0.0392 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by HOXB8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HOXB8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HOXB8 | 3218 | 5 | 2 | 23 | |
| GSE20123 | HOXB8 | 3218 | 5 | 2 | 23 | |
| GSE43470 | HOXB8 | 3218 | 3 | 1 | 39 | |
| GSE46452 | HOXB8 | 3218 | 32 | 0 | 27 | |
| GSE47630 | HOXB8 | 3218 | 9 | 0 | 31 | |
| GSE54993 | HOXB8 | 3218 | 2 | 4 | 64 | |
| GSE54994 | HOXB8 | 3218 | 10 | 6 | 37 | |
| GSE60625 | HOXB8 | 3218 | 4 | 0 | 7 | |
| GSE74703 | HOXB8 | 3218 | 3 | 1 | 32 | |
| GSE74704 | HOXB8 | 3218 | 4 | 1 | 15 | |
| TCGA | HOXB8 | 3218 | 27 | 6 | 63 |
Total number of gains: 104; Total number of losses: 23; Total Number of normals: 361.
Somatic mutations of HOXB8:
Generating mutation plots.
Highly correlated genes for HOXB8:
Showing top 20/127 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HOXB8 | C1orf158 | 0.650786 | 3 | 0 | 3 |
| HOXB8 | DNAH7 | 0.640129 | 3 | 0 | 3 |
| HOXB8 | ARTN | 0.63424 | 3 | 0 | 3 |
| HOXB8 | SYT5 | 0.622573 | 3 | 0 | 3 |
| HOXB8 | RAPGEF3 | 0.617682 | 3 | 0 | 3 |
| HOXB8 | INCENP | 0.616649 | 3 | 0 | 3 |
| HOXB8 | PPP5C | 0.610582 | 4 | 0 | 3 |
| HOXB8 | IGF2-AS | 0.604229 | 3 | 0 | 3 |
| HOXB8 | PGP | 0.593557 | 4 | 0 | 3 |
| HOXB8 | FSCN2 | 0.592445 | 3 | 0 | 3 |
| HOXB8 | GRM4 | 0.584736 | 7 | 0 | 5 |
| HOXB8 | NEUROD2 | 0.584462 | 3 | 0 | 3 |
| HOXB8 | NPFFR1 | 0.58407 | 3 | 0 | 3 |
| HOXB8 | TAOK2 | 0.583093 | 3 | 0 | 3 |
| HOXB8 | FAM204A | 0.581939 | 3 | 0 | 3 |
| HOXB8 | CORT | 0.57737 | 3 | 0 | 3 |
| HOXB8 | HMX1 | 0.577334 | 3 | 0 | 3 |
| HOXB8 | EPPK1 | 0.57681 | 3 | 0 | 3 |
| HOXB8 | BAIAP3 | 0.576037 | 5 | 0 | 3 |
| HOXB8 | CACNA1I | 0.57552 | 6 | 0 | 5 |
For details and further investigation, click here
