MAP3K8

 

Full name: mitogen-activated protein kinase kinase kinase 8 Alias Symbol: Tpl-2|EST|c-COT|MEKK8
Type: protein-coding gene Cytoband: 10p11.23
Entrez ID: 1326 HGNC ID: HGNC:6860 Ensembl Gene: ENSG00000107968 OMIM ID: 191195
Drug and gene relationship at DGIdb

 

MAP3K8 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04668TNF signaling pathway

 

Expression of MAP3K8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAP3K8 1326 205027_s_at -0.4313 0.6371
GSE20347 MAP3K8 1326 205027_s_at -0.6147 0.0603
GSE23400 MAP3K8 1326 205027_s_at -0.0592 0.5049
GSE26886 MAP3K8 1326 205027_s_at -1.1424 0.0060
GSE29001 MAP3K8 1326 205027_s_at -0.8916 0.1853
GSE38129 MAP3K8 1326 205027_s_at -0.5701 0.0564
GSE45670 MAP3K8 1326 205027_s_at -0.0028 0.9925
GSE53622 MAP3K8 1326 26031 -0.4587 0.0001
GSE53624 MAP3K8 1326 26031 -0.5421 0.0000
GSE63941 MAP3K8 1326 205027_s_at -1.7849 0.0720
GSE77861 MAP3K8 1326 235421_at -0.0145 0.9735
GSE97050 MAP3K8 1326 A_33_P3246505 -0.2505 0.3748
SRP007169 MAP3K8 1326 RNAseq -0.8768 0.0756
SRP008496 MAP3K8 1326 RNAseq -0.8981 0.0032
SRP064894 MAP3K8 1326 RNAseq -0.7145 0.0286
SRP133303 MAP3K8 1326 RNAseq -0.1527 0.6417
SRP159526 MAP3K8 1326 RNAseq -0.9097 0.0450
SRP193095 MAP3K8 1326 RNAseq 0.2105 0.2850
SRP219564 MAP3K8 1326 RNAseq -0.4390 0.3822
TCGA MAP3K8 1326 RNAseq -0.1308 0.2453

Upregulated datasets: 0; Downregulated datasets: 1.  


 

Survival by MAP3K8 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of MAP3K8:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAP3K8 1326 5 7 18
GSE20123 MAP3K8 1326 5 6 19
GSE43470 MAP3K8 1326 3 4 36
GSE46452 MAP3K8 1326 1 14 44
GSE47630 MAP3K8 1326 5 15 20
GSE54993 MAP3K8 1326 9 0 61
GSE54994 MAP3K8 1326 3 9 41
GSE60625 MAP3K8 1326 0 0 11
GSE74703 MAP3K8 1326 2 2 32
GSE74704 MAP3K8 1326 0 5 15
TCGA MAP3K8 1326 19 23 54

Total number of gains: 52; Total number of losses: 85; Total Number of normals: 351.  


 

Somatic mutations of MAP3K8:

 

Generating mutation plots.

 

Highly correlated genes for MAP3K8:

 

Showing top 20/334 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAP3K8ATP6V0D10.811864303
MAP3K8TMEM50A0.781671303
MAP3K8PPP4R20.778474303
MAP3K8RDX0.775832303
MAP3K8WARS20.764048303
MAP3K8NDN0.743113303
MAP3K8HSBP10.721741303
MAP3K8NPAT0.720461303
MAP3K8MALT10.709337403
MAP3K8C9orf720.709206403
MAP3K8FBXW110.706804303
MAP3K8TMX40.704625303
MAP3K8EPG50.697602303
MAP3K8PPP2R3C0.69305303
MAP3K8DNAJA20.688206404
MAP3K8TIFA0.687107303
MAP3K8MEGF90.686593303
MAP3K8JMJD1C0.68575504
MAP3K8SLC25A30.681003303
MAP3K8SEC24B0.680321403

For details and further investigation, click here