| Full name: PX domain containing serine/threonine kinase like | Alias Symbol: FLJ20335|Slob | ||
| Type: protein-coding gene | Cytoband: 3p14.3 | ||
| Entrez ID: 54899 | HGNC ID: HGNC:23326 | Ensembl Gene: ENSG00000168297 | OMIM ID: 611450 |
| Drug and gene relationship at DGIdb | |||
Expression of PXK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PXK | 54899 | 225796_at | -0.1101 | 0.8046 | |
| GSE26886 | PXK | 54899 | 225796_at | -0.5662 | 0.0581 | |
| GSE45670 | PXK | 54899 | 225796_at | -0.7964 | 0.0001 | |
| GSE53622 | PXK | 54899 | 58848 | -0.5543 | 0.0000 | |
| GSE53624 | PXK | 54899 | 58848 | -0.4181 | 0.0000 | |
| GSE63941 | PXK | 54899 | 225796_at | -2.2434 | 0.0045 | |
| GSE77861 | PXK | 54899 | 225796_at | -0.0625 | 0.7894 | |
| GSE97050 | PXK | 54899 | A_24_P140204 | -0.0857 | 0.7255 | |
| SRP007169 | PXK | 54899 | RNAseq | -1.0400 | 0.0233 | |
| SRP008496 | PXK | 54899 | RNAseq | -0.4531 | 0.1893 | |
| SRP064894 | PXK | 54899 | RNAseq | -0.1324 | 0.5968 | |
| SRP133303 | PXK | 54899 | RNAseq | -0.2816 | 0.1304 | |
| SRP159526 | PXK | 54899 | RNAseq | -0.6171 | 0.1024 | |
| SRP193095 | PXK | 54899 | RNAseq | -0.1438 | 0.2603 | |
| SRP219564 | PXK | 54899 | RNAseq | -0.1968 | 0.5344 | |
| TCGA | PXK | 54899 | RNAseq | -0.3635 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PXK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PXK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PXK | 54899 | 0 | 17 | 13 | |
| GSE20123 | PXK | 54899 | 0 | 18 | 12 | |
| GSE43470 | PXK | 54899 | 0 | 17 | 26 | |
| GSE46452 | PXK | 54899 | 2 | 17 | 40 | |
| GSE47630 | PXK | 54899 | 1 | 24 | 15 | |
| GSE54993 | PXK | 54899 | 6 | 2 | 62 | |
| GSE54994 | PXK | 54899 | 0 | 32 | 21 | |
| GSE60625 | PXK | 54899 | 5 | 0 | 6 | |
| GSE74703 | PXK | 54899 | 0 | 14 | 22 | |
| GSE74704 | PXK | 54899 | 0 | 11 | 9 | |
| TCGA | PXK | 54899 | 0 | 79 | 17 |
Total number of gains: 14; Total number of losses: 231; Total Number of normals: 243.
Somatic mutations of PXK:
Generating mutation plots.
Highly correlated genes for PXK:
Showing top 20/555 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PXK | RNF146 | 0.748582 | 3 | 0 | 3 |
| PXK | TAOK1 | 0.741958 | 3 | 0 | 3 |
| PXK | ITIH5 | 0.737222 | 3 | 0 | 3 |
| PXK | BDH2 | 0.736425 | 3 | 0 | 3 |
| PXK | CD59 | 0.735003 | 3 | 0 | 3 |
| PXK | FMOD | 0.734914 | 4 | 0 | 4 |
| PXK | XPC | 0.734681 | 3 | 0 | 3 |
| PXK | VAMP2 | 0.728735 | 3 | 0 | 3 |
| PXK | FBXL3 | 0.725294 | 3 | 0 | 3 |
| PXK | TBC1D19 | 0.724811 | 3 | 0 | 3 |
| PXK | HSD11B1 | 0.722087 | 3 | 0 | 3 |
| PXK | SNX7 | 0.708452 | 3 | 0 | 3 |
| PXK | HOXA3 | 0.705366 | 3 | 0 | 3 |
| PXK | RABAC1 | 0.70454 | 3 | 0 | 3 |
| PXK | PFDN5 | 0.700328 | 3 | 0 | 3 |
| PXK | TBC1D28 | 0.697293 | 3 | 0 | 3 |
| PXK | ZDHHC17 | 0.697028 | 3 | 0 | 3 |
| PXK | ARHGEF6 | 0.687072 | 5 | 0 | 4 |
| PXK | LRRN4CL | 0.685832 | 5 | 0 | 4 |
| PXK | TMEM170B | 0.685296 | 3 | 0 | 3 |
For details and further investigation, click here
