| Full name: UDP-glucuronate decarboxylase 1 | Alias Symbol: FLJ23591|UGD|SDR6E1 | ||
| Type: protein-coding gene | Cytoband: 2q12.2 | ||
| Entrez ID: 80146 | HGNC ID: HGNC:17729 | Ensembl Gene: ENSG00000115652 | OMIM ID: 609749 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UXS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UXS1 | 80146 | 225583_at | 0.9715 | 0.0324 | |
| GSE20347 | UXS1 | 80146 | 219675_s_at | 0.2691 | 0.0799 | |
| GSE23400 | UXS1 | 80146 | 219675_s_at | 0.4819 | 0.0000 | |
| GSE26886 | UXS1 | 80146 | 225583_at | 0.2788 | 0.3041 | |
| GSE29001 | UXS1 | 80146 | 219675_s_at | 0.3216 | 0.3739 | |
| GSE38129 | UXS1 | 80146 | 219675_s_at | 0.5876 | 0.0007 | |
| GSE45670 | UXS1 | 80146 | 225583_at | 0.4674 | 0.0277 | |
| GSE53622 | UXS1 | 80146 | 4178 | 0.3082 | 0.0001 | |
| GSE53624 | UXS1 | 80146 | 4178 | 0.3395 | 0.0001 | |
| GSE63941 | UXS1 | 80146 | 225583_at | -1.7672 | 0.0018 | |
| GSE77861 | UXS1 | 80146 | 219675_s_at | 0.8594 | 0.0021 | |
| GSE97050 | UXS1 | 80146 | A_23_P67829 | 0.3132 | 0.1808 | |
| SRP007169 | UXS1 | 80146 | RNAseq | 0.5091 | 0.2660 | |
| SRP008496 | UXS1 | 80146 | RNAseq | 0.9546 | 0.0027 | |
| SRP064894 | UXS1 | 80146 | RNAseq | 0.3962 | 0.0049 | |
| SRP133303 | UXS1 | 80146 | RNAseq | 0.6771 | 0.0001 | |
| SRP159526 | UXS1 | 80146 | RNAseq | 1.1498 | 0.0004 | |
| SRP193095 | UXS1 | 80146 | RNAseq | 0.2876 | 0.0154 | |
| SRP219564 | UXS1 | 80146 | RNAseq | 0.0079 | 0.9837 | |
| TCGA | UXS1 | 80146 | RNAseq | 0.0662 | 0.2732 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by UXS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UXS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UXS1 | 80146 | 3 | 2 | 25 | |
| GSE20123 | UXS1 | 80146 | 3 | 2 | 25 | |
| GSE43470 | UXS1 | 80146 | 3 | 1 | 39 | |
| GSE46452 | UXS1 | 80146 | 1 | 4 | 54 | |
| GSE47630 | UXS1 | 80146 | 7 | 0 | 33 | |
| GSE54993 | UXS1 | 80146 | 0 | 6 | 64 | |
| GSE54994 | UXS1 | 80146 | 10 | 0 | 43 | |
| GSE60625 | UXS1 | 80146 | 0 | 3 | 8 | |
| GSE74703 | UXS1 | 80146 | 3 | 1 | 32 | |
| GSE74704 | UXS1 | 80146 | 2 | 2 | 16 | |
| TCGA | UXS1 | 80146 | 34 | 5 | 57 |
Total number of gains: 66; Total number of losses: 26; Total Number of normals: 396.
Somatic mutations of UXS1:
Generating mutation plots.
Highly correlated genes for UXS1:
Showing top 20/1186 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UXS1 | SS18L1 | 0.817099 | 3 | 0 | 3 |
| UXS1 | CRTC2 | 0.811196 | 3 | 0 | 3 |
| UXS1 | SFR1 | 0.805339 | 3 | 0 | 3 |
| UXS1 | MTRR | 0.804033 | 3 | 0 | 3 |
| UXS1 | GOLGA3 | 0.80184 | 3 | 0 | 3 |
| UXS1 | SFT2D3 | 0.80159 | 3 | 0 | 3 |
| UXS1 | KRTCAP2 | 0.795994 | 3 | 0 | 3 |
| UXS1 | SGSH | 0.790205 | 3 | 0 | 3 |
| UXS1 | CDCA2 | 0.783762 | 4 | 0 | 4 |
| UXS1 | ZFYVE27 | 0.783398 | 3 | 0 | 3 |
| UXS1 | RGL1 | 0.777005 | 3 | 0 | 3 |
| UXS1 | WDR75 | 0.775253 | 4 | 0 | 3 |
| UXS1 | RNF217 | 0.773579 | 4 | 0 | 4 |
| UXS1 | TAP1 | 0.77178 | 4 | 0 | 4 |
| UXS1 | STX16 | 0.771209 | 3 | 0 | 3 |
| UXS1 | CPNE8 | 0.765369 | 4 | 0 | 4 |
| UXS1 | TMEM18 | 0.762955 | 3 | 0 | 3 |
| UXS1 | TMEM60 | 0.759986 | 4 | 0 | 4 |
| UXS1 | HSD11B1 | 0.759604 | 3 | 0 | 3 |
| UXS1 | SESN3 | 0.744291 | 3 | 0 | 3 |
For details and further investigation, click here
